Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

CSF Protein Contents and Their Roles in Brain Development

Mohammad Nabiuni 1 , * , Rozmehr Shokohi 1 and Parisa Moghaddam 1
Authors Information
1 Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: September 28, 2015, 17 (9); e1042
  • Published Online: September 26, 2015
  • Article Type: Review Article
  • Received: January 6, 2014
  • Accepted: March 18, 2014
  • DOI: 10.17795/zjrms-1042

To Cite: Nabiuni M, Shokohi R, Moghaddam P. CSF Protein Contents and Their Roles in Brain Development, Zahedan J Res Med Sci. 2015 ; 17(9):e1042. doi: 10.17795/zjrms-1042.

Copyright © 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Vera A, Stanic K, Montecinos H, Torrejon M, Marcellini S, Caprile T. SCO-spondin from embryonic cerebrospinal fluid is required for neurogenesis during early brain development. Front Cell Neurosci. 2013; 7: 80[DOI][PubMed]
  • 2. Mashayekhi F. The importance of cerebrospinal fluid in cerebral cortical development. Iran J Sci Technol. 2012; : 493-9
  • 3. Redzic ZB, Preston JE, Duncan JA, Chodobski A, Szmydynger-Chodobska J. The choroid plexus-cerebrospinal fluid system: from development to aging. Curr Top Dev Biol. 2005; 71: 1-52[DOI][PubMed]
  • 4. Hughes AL, Pakhomova A, Brown PD. Regulatory volume increase in epithelial cells isolated from the mouse fourth ventricle choroid plexus involves Na(+)-H(+) exchange but not Na(+)-K(+)-2Cl(-) cotransport. Brain Res. 2010; 1323: 1-10[DOI][PubMed]
  • 5. Oreskovic D, Klarica M. The formation of cerebrospinal fluid: nearly a hundred years of interpretations and misinterpretations. Brain Res Rev. 2010; 64(2): 241-62[DOI][PubMed]
  • 6. Lehtinen MK, Walsh CA. Neurogenesis at the brain-cerebrospinal fluid interface. Annu Rev Cell Dev Biol. 2011; 27: 653-79[DOI][PubMed]
  • 7. Wostyn P, Audenaert K, De Deyn PP. Choroidal Proteins Involved in Cerebrospinal Fluid Production may be Potential Drug Targets for Alzheimer's Disease Therapy. Perspect Medicin Chem. 2011; 5: 11-7[DOI][PubMed]
  • 8. Martin C, Alonso MI, Santiago C, Moro JA, De la Mano A, Carretero R, et al. Early embryonic brain development in rats requires the trophic influence of cerebrospinal fluid. Int J Dev Neurosci. 2009; 27(7): 733-40[DOI][PubMed]
  • 9. Mashayekhi F, Salehi Z. The importance of cerebrospinal fluid on neural cell proliferation in developing chick cerebral cortex. Eur J Neurol. 2006; 13(3): 266-72[DOI][PubMed]
  • 10. Miyan JA, Nabiyouni M, Zendah M. Development of the brain: a vital role for cerebrospinal fluid. Can J Physiol Pharmacol. 2003; 81(4): 317-28[DOI][PubMed]
  • 11. Miyan J. CSF circulation and cerebral cortex development. Cerebrospinal Fluid Res. 2009; 6
  • 12. Gato A, Desmond ME. Why the embryo still matters: CSF and the neuroepithelium as interdependent regulators of embryonic brain growth, morphogenesis and histiogenesis. Dev Biol. 2009; 327(2): 263-72[DOI][PubMed]
  • 13. Gato A, Moro JA, Alonso MI, Bueno D, De La Mano A, Martin C. Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos. Anat Rec A Discov Mol Cell Evol Biol. 2005; 284(1): 475-84[DOI][PubMed]
  • 14. Nabiuni M, Rasouli J, Parivar K, Kochesfehani HM, Irian S, Miyan JA. In vitro effects of fetal rat cerebrospinal fluid on viability and neuronal differentiation of PC12 cells. Fluids Barriers CNS. 2012; 9(1): 8[DOI][PubMed]
  • 15. Redzic ZB, Segal MB. The structure of the choroid plexus and the physiology of the choroid plexus epithelium. Adv Drug Deliv Rev. 2004; 56(12): 1695-716[DOI][PubMed]
  • 16. Zappaterra MD, Lisgo SN, Lindsay S, Gygi SP, Walsh CA, Ballif BA. A comparative proteomic analysis of human and rat embryonic cerebrospinal fluid. J Proteome Res. 2007; 6(9): 3537-48[DOI][PubMed]
  • 17. Buddensiek J, Dressel A, Kowalski M, Runge U, Schroeder H, Hermann A, et al. Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation. BMC Neurosci. 2010; 11: 48[DOI][PubMed]
  • 18. Mashayekhi F, Azari M, Moghadam LM, Yazdankhah M, Naji M, Salehi Z. Changes in cerebrospinal fluid nerve growth factor levels during chick embryonic development. J Clin Neurosci. 2009; 16(10): 1334-7[DOI][PubMed]
  • 19. Reiber H. Flow rate of cerebrospinal fluid (CSF)--a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci. 1994; 122(2): 189-203[PubMed]
  • 20. Wong RW, Guillaud L. The role of epidermal growth factor and its receptors in mammalian CNS. Cytokine Growth Factor Rev. 2004; 15(2-3): 147-56[DOI][PubMed]
  • 21. Yari S, Parivar K, Nabiuni M, Keramatipour M. Effect of e-CSF on morphological changes of neurosphere derived astrocytes. J Am Sci. 2012; 8(12): 1109-13
  • 22. Solozobova V, Wyvekens N, Pruszak J. Lessons from the embryonic neural stem cell niche for neural lineage differentiation of pluripotent stem cells. Stem Cell Rev. 2012; 8(3): 813-29[DOI][PubMed]
  • 23. Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, et al. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron. 2011; 69(5): 893-905[DOI][PubMed]
  • 24. Koo H, Choi BH. Expression of glial cell line-derived neurotrophic factor (GDNF) in the developing human fetal brain. Int J Dev Neurosci. 2001; 19(6): 549-58[PubMed]
  • 25. Falcao AM, Marques F, Novais A, Sousa N, Palha JA, Sousa JC. The path from the choroid plexus to the subventricular zone: go with the flow! Front Cell Neurosci. 2012; 6: 34[DOI][PubMed]
  • 26. Alonso MI, Martin C, Carnicero E, Bueno D, Gato A. Cerebrospinal fluid control of neurogenesis induced by retinoic acid during early brain development. Dev Dyn. 2011; 240(7): 1650-9[DOI][PubMed]
  • 27. Rawson NE, LaMantia AS. A speculative essay on retinoic acid regulation of neural stem cells in the developing and aging olfactory system. Exp Gerontol. 2007; 42(1-2): 46-53[DOI][PubMed]
  • 28. Bachy I, Kozyraki R, Wassef M. The particles of the embryonic cerebrospinal fluid: how could they influence brain development? Brain Res Bull. 2008; 75(2-4): 289-94[DOI][PubMed]
  • 29. Diaz-Ruiz C, Perez-Tomas R, Domingo J, Ferrer I. Immunohistochemical localization of transforming growth factor-alpha in choroid plexus of the rat and chicken. Neurosci Lett. 1993; 164(1-2): 44-6[PubMed]
  • 30. Mashayekhi F, Salehi Z. Relative expression of hepatocyte growth factor in cerebrospinal fluid during mouse embryonic development and early postnatal stage; A Western Blot analysis. Ann Biol Res. 2011; 2(5): 1-7
  • 31. Roskoski RJ. VEGF receptor protein-tyrosine kinases: structure and regulation. Biochem Biophys Res Commun. 2008; 375(3): 287-91[DOI][PubMed]
  • 32. Rosenstein JM, Mani N, Khaibullina A, Krum JM. Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons. J Neurosci. 2003; 23(35): 11036-44[PubMed]
  • 33. Gauthier S, Kaur G, Mi W, Tizon B, Levy E. Protective mechanisms by cystatin C in neurodegenerative diseases. Front Biosci (Schol Ed). 2011; 3: 541-54[PubMed]
  • 34. Eisenach JC, Thomas JA, Rauck RL, Curry R, Li X. Cystatin C in cerebrospinal fluid is not a diagnostic test for pain in humans. Pain. 2004; 107(3): 207-12[PubMed]
  • 35. Farkas LM, Jaszai J, Unsicker K, Krieglstein K. Characterization of bone morphogenetic protein family members as neurotrophic factors for cultured sensory neurons. Neuroscience. 1999; 92(1): 227-35[PubMed]
  • 36. Stolp HB. Neuropoietic cytokines in normal brain development and neurodevelopmental disorders. Mol Cell Neurosci. 2013; 53: 63-8[DOI][PubMed]
  • 37. Segklia A, Seuntjens E, Elkouris M, Tsalavos S, Stappers E, Mitsiadis TA, et al. Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse. PLoS One. 2012; 7(3)[DOI][PubMed]
  • 38. Gomes WA, Mehler MF, Kessler JA. Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment. Dev Biol. 2003; 255(1): 164-77[PubMed]
  • 39. O'Keeffe GW, Hanke M, Pohl J, Sullivan AM. Expression of growth differentiation factor-5 in the developing and adult rat brain. Brain Res Dev Brain Res. 2004; 151(1-2): 199-202[DOI][PubMed]
  • 40. Boato F, Hechler D, Rosenberger K, Ludecke D, Peters EM, Nitsch R, et al. Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro. J Neuroinflammation. 2011; 8: 183[DOI][PubMed]
  • 41. Baune BT, Konrad C, Grotegerd D, Suslow T, Birosova E, Ohrmann P, et al. Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain. J Neuroinflammation. 2012; 9: 125[DOI][PubMed]
  • 42. Padberg F, Feneberg W, Schmidt S, Schwarz MJ, Korschenhausen D, Greenberg BD, et al. CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis. J Neuroimmunol. 1999; 99(2): 218-23[PubMed]
  • 43. Vergara C, Ramirez B. CNTF, a pleiotropic cytokine: emphasis on its myotrophic role. Brain Res Brain Res Rev. 2004; 47(1-3): 161-73[DOI][PubMed]
  • 44. Talbott JF, Cao Q, Bertram J, Nkansah M, Benton RL, Lavik E, et al. CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Exp Neurol. 2007; 204(1): 485-9[DOI][PubMed]
  • 45. Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 2001; 24: 677-736[DOI][PubMed]
  • 46. Spuch C, Carro E. The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium. BMC Neurosci. 2011; 12: 39[DOI][PubMed]
  • 47. Nabiyouni M, Storey C, Owen-Lynch J, Miyan J. Proteomics study of CSF composition in the developing H-Tx rat. Cerebrospinal Fluid Res. 2004; 1[DOI]
  • 48. Zuccato C, Cattaneo E. Role of brain-derived neurotrophic factor in Huntington's disease. Prog Neurobiol. 2007; 81(5-6): 294-330[DOI][PubMed]
  • 49. Yari S, Parivar K, Nabiuni M, Keramatipour M. Effect of embryonic cerebrospinal fluid on proliferation and differentiation of neuroprogenitor cells. Cell J. 2013; 15(1): 29-36[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments