Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats

Mohammad Reza Shahraki 1 , * , Tayyebe Forghani 1 , Mehdi Mohammadi 2 and Abdurrashid Khazaei-Feizalabad 3
Authors Information
1 Department of Physiology, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Department of Statistics and Epidemiology, Faculty of Health, Zahedan University of Medical Sciences, Zahedan, IR Iran
3 Department of English, Zahedan University of Medical Sciences, Zahedan, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: September 28, 2015, 17 (9); e1059
  • Published Online: September 26, 2015
  • Article Type: Research Article
  • Received: June 30, 2014
  • Accepted: August 5, 2014
  • DOI: 10.17795/zjrms-1059

To Cite: Shahraki M R, Forghani T, Mohammadi M, Khazaei-Feizalabad A. The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats, Zahedan J Res Med Sci. 2015 ; 17(9):e1059. doi: 10.17795/zjrms-1059.

Copyright © 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Boran C, Ozkan KU. The effect of zinc therapy on damaged testis in pre-pubertal rats. Pediatr Surg Int. 2004; 20(6): 444-8[DOI][PubMed]
  • 2. Sankavaram K, Chong L, Bruno RS, Freake HC. Zinc status alters growth and oxidative stress responses in rat hepatoma cells. Nutr Cancer. 2014; 66(1): 104-16[DOI][PubMed]
  • 3. Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, et al. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. J Cell Physiol. 2010; 224(3): 567-74[DOI][PubMed]
  • 4. Ranaldi G, Perozzi G, Truong-Tran A, Zalewski P, Murgia C. Intracellular distribution of labile Zn(II) and zinc transporter expression in kidney and MDCK cells. Am J Physiol Renal Physiol. 2002; 283(6)-75[DOI][PubMed]
  • 5. Hambidge KM, Krebs NF. Zinc deficiency: a special challenge. J Nutr. 2007; 137(4): 1101-5[PubMed]
  • 6. da Silva R, dos Santos-Valente EC, Burim Scomparini F, Saccardo Sarni RO, Costa-Carvalho BT. The relationship between nutritional status, vitamin A and zinc levels and oxidative stress in patients with ataxia-telangiectasia. Allergol Immunopathol (Madr). 2014; 42(4): 329-35[DOI][PubMed]
  • 7. Ott ES, Shay NF. Zinc deficiency reduces leptin gene expression and leptin secretion in rat adipocytes. Exp Biol Med (Maywood). 2001; 226(9): 841-6[PubMed]
  • 8. Fukushima T, Tan X, Luo Y, Kanda H. Serum vitamins and heavy metals in blood and urine, and the correlations among them in Parkinson's disease patients in China. Neuroepidemiology. 2011; 36(4): 240-4[DOI][PubMed]
  • 9. Krebs N, Langkammer C, Goessler W, Ropele S, Fazekas F, Yen K, et al. Assessment of trace elements in human brain using inductively coupled plasma mass spectrometry. J Trace Elem Med Biol. 2014; 28(1): 1-7[DOI][PubMed]
  • 10. Panayi AE, Spyrou NM, Iversen BS, White MA, Part P. Determination of cadmium and zinc in Alzheimer's brain tissue using inductively coupled plasma mass spectrometry. J Neurol Sci. 2002; 195(1): 1-10[PubMed]
  • 11. Blundell R, Adam F. Haemolytic anaemia and acute pancreatitis associated with zinc toxicosis in a dog. Vet Rec. 2013; 172(1): 17[DOI][PubMed]
  • 12. Mocchegiani E, Bertoni-Freddari C, Marcellini F, Malavolta M. Brain, aging and neurodegeneration: role of zinc ion availability. Prog Neurobiol. 2005; 75(6): 367-90[DOI][PubMed]
  • 13. Iguchi K, Usui S, Inoue T, Sugimura Y, Tatematsu M, Hirano K. High-level expression of zinc transporter-2 in the rat lateral and dorsal prostate. J Androl. 2002; 23(6): 819-24[PubMed]
  • 14. Martin GB, White CL, Markey CM, Blackberry MA. Effects of dietary zinc deficiency on the reproductive system of young male sheep: testicular growth and the secretion of inhibin and testosterone. J Reprod Fertil. 1994; 101(1): 87-96[PubMed]
  • 15. Dissanayake D, Wijesinghe PS, Ratnasooriya WD, Wimalasena S. Effects of zinc supplementation on sexual behavior of male rats. J Hum Reprod Sci. 2009; 2(2): 57-61[DOI][PubMed]
  • 16. Madureira G, Bloise W, Mendonca BB, Brandao-Neto J. Effect of acute and chronic oral zinc administration in hyperprolactinemic patients. Met Based Drugs. 1999; 6(3): 159-62[DOI][PubMed]
  • 17. Kim JS, Yun CH. Inhibition of human cytochrome P450 3A4 activity by zinc(II) ion. Toxicol Lett. 2005; 156(3): 341-50[DOI][PubMed]
  • 18. Daniels WM, Hendricks J, Salie R, van Rensburg SJ. A mechanism for zinc toxicity in neuroblastoma cells. Metab Brain Dis. 2004; 19(1-2): 79-88[PubMed]
  • 19. Karaca Z, Tanriverdi F, Kurtoglu S, Tokalioglu S, Unluhizarci K, Kelestimur F. Pubertal arrest due to Zn deficiency: the effect of zinc supplementation. Hormones (Athens). 2007; 6(1): 71-4[PubMed]
  • 20. Kochman K, Gajewska A, Kozlowski H, Masiukiewicz E, Rzeszotarska B. Increased LH and FSH release from the anterior pituitary of ovariectomized rat, in vivo, by copper-, nickel-, and zinc-LHRH complexes. J Inorg Biochem. 1992; 48(1): 41-6[PubMed]
  • 21. Jeong SW, Park BG, Park JY, Lee JW, Lee JH. Divalent metals differentially block cloned T-type calcium channels. Neuroreport. 2003; 14(11): 1537-40[DOI][PubMed]
  • 22. Magistretti J, Castelli L, Taglietti V, Tanzi F. Dual effect of Zn2+ on multiple types of voltage-dependent Ca2+ currents in rat palaeocortical neurons. Neuroscience. 2003; 117(2): 249-64[PubMed]
  • 23. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 2007;
  • 24. Yu L, Jiang R, Su Q, Yu H, Yang J. Hippocampal neuronal metal ion imbalance related oxidative stress in a rat model of chronic aluminum exposure and neuroprotection of meloxicam. Behav Brain Funct. 2014; 10: 6[DOI][PubMed]
  • 25. Hsieh H, Amlal H, Genter MB. Evaluation of the toxicity of zinc in the rat olfactory neuronal cell line, Odora. Hum Exp Toxicol. 2015; 34(3): 308-14[DOI][PubMed]
  • 26. Baraka AM, Hassab El Nabi W, El Ghotni S. Investigating the role of zinc in a rat model of epilepsy. CNS Neurosci Ther. 2012; 18(4): 327-33[DOI][PubMed]
  • 27. Saint Pol P, Hermand E, Tramu G. Paracrine factors in adult rat testis gonadotrophin control of opioids and LHRH like peptide. Andrologia. 1988; 20(2): 173-81[PubMed]
  • 28. Hirasawa H, Betensky RA, Raviola E. Corelease of dopamine and GABA by a retinal dopaminergic neuron. J Neurosci. 2012; 32(38): 13281-91[DOI][PubMed]
  • 29. Marubayashi U, Yu WH, McCann SM. Median eminence lesions reveal separate hypothalamic control of pulsatile follicle-stimulating hormone and luteinizing hormone release. Proc Soc Exp Biol Med. 1999; 220(3): 139-46[PubMed]
  • 30. Wilding JP. Neuropeptides and appetite control. Diabet Med. 2002; 19(8): 619-27[PubMed]
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