Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Serum Level of Resistin in Patients with Hyperthyroidism and Hypothyroidism

Mehdi Hedayati 1 , * , Sanaz Shabani 2 , Mahsa Frazndemehr 2 , Marjan Zarif-Yegane 1 and Lale Hoghooghrad 1
Authors Information
1 Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: November 2, 2013, 16 (11); e23370
  • Published Online: November 2, 2013
  • Article Type: Research Article
  • Received: January 10, 2012
  • Accepted: March 15, 2012

To Cite: Hedayati M, Shabani S, Frazndemehr M, Zarif-Yegane M, Hoghooghrad L. Serum Level of Resistin in Patients with Hyperthyroidism and Hypothyroidism, Zahedan J Res Med Sci. 2013 ; 16(11):e23370.

Copyright © 2013, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
3. Materials and Methods
4. Results
5. Discussion
  • 1. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001; 409(6818): 307-12[DOI][PubMed]
  • 2. Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, et al. Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab. 2003; 88(11): 5452-5[DOI][PubMed]
  • 3. McTernan CL, McTernan PG, Harte AL, Levick P, Barnett A, Kumar S. Resistin, central obesity, and type 2 diabetes. The Lancet. 2002; 359(9300): 46-7
  • 4. Ukkola O. Resistin - a mediator of obesity-associated insulin resistance or an innocent bystander? Eur J Endocrinol. 2002; 147(5): 571-4[PubMed]
  • 5. Sentinelli F, Romeo S, Arca M, Filippi E, Leonetti F, Banchieri M, et al. Human resistin gene, obesity, and type 2 diabetes: mutation analysis and population study. Diabetes. 2002; 51(3): 860-2[PubMed]
  • 6. Osawa H, Onuma H, Murakami A, Ochi M, Nishimiya T, Kato K, et al. Systematic Search for Single Nucleotide Polymorphisms in the Resistin Gene The Absence of Evidence for the Association of Three Identified Single Nucleotide Polymorphisms With Japanese Type 2 Diabetes. Diabetes. 2002; 51(3): 863-6
  • 7. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, et al. Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab. 2003; 88(10): 4848-56
  • 8. Luvizotto R, Sibio M, Olímpio R, Nascimento AF, Lima-Leopoldo AP, Leopoldo AS, et al. Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Horm metab res. 2011; 43(7): 452-7
  • 9. Iglesias P, Alvarez Fidalgo P, Codoceo R, Díez JJ. Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function. Clin ndocrinol. 2003; 59(5): 621-9
  • 10. Yaturu S, Prado S, Grimes SR. Changes in adipocyte hormones leptin, resistin, and adiponectin in thyroid dysfunction. J cell biochem. 2004; 93(3): 491-6
  • 11. Krassas GE, Pontikides N, Loustis K, Koliakos G, Constantinidis T, Panidis D. Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition. Eur J endocrinol. 2005; 153(2): 217-21
  • 12. Bossowski A, Sawicka B, Szalecki M, Koput A, Wysocka J, Żelazowska-Rutkowska B. Analysis of serum adiponectin, resistin and leptin levels in children and adolescents with autoimmune thyroid disorders. J Pediatr Endocrinol Metab. 2010; 23(4): 369-77
  • 13. Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C, et al. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res. 2003; 11(9): 1048-54
  • 14. Sieminska L, Niedziolka D, Pillich A, Kos-Kudla B, Marek B, Nowak M, et al. Serum concentrations of adiponectin and resistin in hyperthyroid Graves’ disease patients. J Endocrinol Invest. 2008; 31(9): 745-9
  • 15. Guldiken S. , Demir M. , Arikan E. . Adipokines in patients with overt hypothyroidism and subclinical hypothyroidism. 2008;
  • 16. Nogueiras R, Gualillo O, Caminos JC, Casanueva FF, Diéguez C. Regulation of resistin by gonadal, thyroid hormone, and nutritional status. Obes Res. 2003; 11(3): 408-14
  • 17. Wolfe B.E. , Jimerson D. C. , Orlova C. , Mantzoros C. S. . Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers. Clin Endocrinol. 2004; 31(3): 332-8
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