Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Role of Interferon-Gamma in Bronchoalveolar Lavage Fluid on Distinguishing Active Pulmonary Tuberculosis from other Pulmonary Diseases

Nezar Ali Moulaei 1 , Abbas Ali Niazi 2 , Ali Saeidpour-Parizi 3 , * and Samira Shahba 4
Authors Information
1 Department of Internal Medicine, Research Center for Tropical and Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran
2 Department of Pathology, Zahedan University of Medical Sciences, Zahedan, Iran
3 Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4 Department of Microbiology, Faculty of Basic Sciences, Tehran Sciences and Research Branch, Islamic Azad University, Tehran, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: November 28, 2014, 16 (11); e23371
  • Published Online: August 21, 2013
  • Article Type: Research Article
  • Received: May 22, 2013
  • Accepted: July 18, 2013

To Cite: Ali Moulaei N, Ali Niazi A, Saeidpour-Parizi A, Shahba S. Role of Interferon-Gamma in Bronchoalveolar Lavage Fluid on Distinguishing Active Pulmonary Tuberculosis from other Pulmonary Diseases, Zahedan J Res Med Sci. 2014 ; 16(11):e23371.

Copyright © 2014 Zahedan University of Medical Sciences. All rights reserved.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Materials and Methods
  • 1. Global tuberculosis control. 2011;
  • 2. Saif Alfaresi M, Hag-Ali M. Susceptibility Pattern and Epidemiology of Mycobacterium tuberculosis in United Emirati Hospital. Open Microbiol J. 2010; 4: 1-4[DOI][PubMed]
  • 3. Mario C, Raviglione MC, O'Brien RJ. Harrison῾s principles of internal medicine. 2008; : 1016-25
  • 4. Kayacan O, Karnak D, Delibalta M, Beder S, Karaca L, Tutkak H. Adenosine deaminase activity in bronchoalveolar lavage in Turkish patients with smear negative pulmonary tuberculosis. Respir Med. 2002; 96(7): 536-41[PubMed]
  • 5. Anderson RM. The pandemic of antibiotic resistance. Nat Med. 1999; 5(2): 147-9[DOI][PubMed]
  • 6. Mirhaghani L, Nasehi M. National guidelines for TB control. 2002;
  • 7. Halvani AB, Binesh F. Adenosine deaminase activity in bronchoalveolar lavage fluid in patients with smear-negative pulmonary tuberculosis. Tanaffos Respir. 2008; 7(2): 45-9
  • 8. Belli F, Capra A, Moraiti A, Rossi S, Rossi P. Cytokines assay in peripheral blood and bronchoalveolar lavage in the diagnosis and staging of pulmonary granulomatous diseases. Int J Immunopathol Pharmacol. 2000; 13(2): 61-7[PubMed]
  • 9. Su SB, Qin SY, Guo XY, Luo W, Jiang HX. Assessment by meta-analysis of interferon-gamma for the diagnosis of tuberculous peritonitis. World J Gastroenterol. 2013; 19(10): 1645-51[DOI][PubMed]
  • 10. Hussain S, Afzal N, Javaid K, Ullah MI, Ahmad T, Saleem Uz Z. Level of interferon gamma in the blood of tuberculosis patients. Iran J Immunol. 2010; 7(4): 240-6[PubMed]
  • 11. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med. 1993; 178(6): 2243-7[PubMed]
  • 12. Pearl JE, Saunders B, Ehlers S, Orme IM, Cooper AM. Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse. Cell Immunol. 2001; 211(1): 43-50[DOI][PubMed]
  • 13. Hirsch CS, Toossi Z, Othieno C, Johnson JL, Schwander SK, Robertson S, et al. Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J Infect Dis. 1999; 180(6): 2069-73[DOI][PubMed]
  • 14. Seah GT, Scott GM, Rook GA. Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis. J Infect Dis. 2000; 181(1): 385-9[DOI][PubMed]
  • 15. Smith SM, Klein MR, Malin AS, Sillah J, McAdam KP, Dockrell HM. Decreased IFN- gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients. Tuberculosis (Edinb). 2002; 82(1): 7-13[DOI][PubMed]
  • 16. Turner J, Corrah T, Sabbally S, Whittle H, Dockrell HM. A longitudinal study of in vitro IFNgamma production and cytotoxic T cell responses of tuberculosis patients in the gambia. Tuber Lung Dis. 2000; 80(3): 161-9[DOI][PubMed]
  • 17. Dlugovitzky D, Torres-Morales A, Rateni L, Farroni MA, Largacha C, Molteni O, et al. Circulating profile of Th1 and Th2 cytokines in tuberculosis patients with different degrees of pulmonary involvement. FEMS Immunol Med Microbiol. 1997; 18(3): 203-7[PubMed]
  • 18. Verbon A, Juffermans N, Van Deventer SJ, Speelman P, Van Deutekom H, Van Der Poll T. Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment. Clin Exp Immunol. 1999; 115(1): 110-3[PubMed]
  • 19. Toossi Z, Kleinhenz ME, Ellner JJ. Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis. J Exp Med. 1986; 163(5): 1162-72[PubMed]
  • 20. Torres M, Herrera T, Villareal H, Rich EA, Sada E. Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis. Infect Immun. 1998; 66(1): 176-80[PubMed]
  • 21. Tsao TC, Huang CC, Chiou WK, Yang PY, Hsieh MJ, Tsao KC. Levels of interferon-gamma and interleukin-2 receptor-alpha for bronchoalveolar lavage fluid and serum were correlated with clinical grade and treatment of pulmonary tuberculosis. Int J Tuberc Lung Dis. 2002; 6(8): 720-7[PubMed]
  • 22. Kupeli E, Karnak D, Beder S, Kayacan O, Tutkak H. Diagnostic accuracy of cytokine levels (TNF-alpha, IL-2 and IFN-gamma) in bronchoalveolar lavage fluid of smear-negative pulmonary tuberculosis patients. Respiration. 2008; 75(1): 73-8[DOI][PubMed]
  • 23. Antonangelo L, Vargas F, Figueiredo V. Interfron-gamma and adenosine deaminase in the bronchoalveolar lavage of patiens with pulmonary tuberclosis and negative sputum. Chest. 2006; 23(2): 346-60
  • 24. Boonsarngsuk V, Suwannaphong S, Laohavich C. Combination of adenosine deaminase activity and polymerase chain reaction in bronchoalveolar lavage fluid in the diagnosis of smear-negative active pulmonary tuberculosis. Int J Infect Dis. 2012; 16(9)-8[DOI][PubMed]
  • 25. Jafari C, Ernst M, Kalsdorf B, Greinert U, Diel R, Kirsten D, et al. Rapid diagnosis of smear-negative tuberculosis by bronchoalveolar lavage enzyme-linked immunospot. Am J Respir Crit Care Med. 2006; 174(9): 1048-54[DOI][PubMed]
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