Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Azam Moshfegh 1 and Mahbubeh Setorki 2 , *
Authors Information
1 Department of Biology, Lahijan Branch, Islamic Azad University, Lahijan, IR Iran
2 Department of Biology, Izeh Branch, Islamic Azad University, Izeh, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: September 2017, 19 (9); e10927
  • Published Online: September 30, 2017
  • Article Type: Research Article
  • Received: June 25, 2017
  • Revised: July 30, 2017
  • Accepted: August 30, 2017
  • DOI: 10.5812/zjrms.10927

To Cite: Moshfegh A, Setorki M. Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat, Zahedan J Res Med Sci. 2017 ; 19(9):e10927. doi: 10.5812/zjrms.10927.

Copyright © 2017, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. White BC, Sullivan JM, DeGracia DJ, O’Neil BJ, Neumar RW, Grossman LI, et al. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci. 2000; 179(1-2): 1-33[DOI]
  • 2. Coyle J, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 1993; 262(5134): 689-95[DOI]
  • 3. Bano D, Nicotera P. Ca2+ signals and neuronal death in brain ischemia. Stroke. 2007; 38(2 Suppl): 674-6[DOI][PubMed]
  • 4. Faraci FM. Protecting the brain with eNOS: run for your life. Circ Res. 2006; 99(10): 1029-30[DOI][PubMed]
  • 5. Rami A, Langhagen A, Steiger S. Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiol Dis. 2008; 29(1): 132-41[DOI][PubMed]
  • 6. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999; 79(4): 1431-568[PubMed]
  • 7. Markgraf CG, Velayo NL, Johnson MP, McCarty DR, Medhi S, Koehl JR, et al. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats. Stroke. 1998; 29(1): 152-8[PubMed]
  • 8. Zavareh SAT, Hamidi G, Salami M. Long term potentiation as a mechanism for learning and memory. Yakhteh Med J. 2009; 11(2): 88-105
  • 9. Kesner RP, Adelstein TB, Crutcher KA. Equivalent spatial location memory deficits in rats with medial septum or hippocampal formation lesions and patients with dementia of the Alzheimer's type. Brain Cogn. 1989; 9(2): 289-300[DOI]
  • 10. Kumral A, Uysal N, Tugyan K, Sonmez A, Yilmaz O, Gokmen N, et al. Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in rats. Behav Brain Res. 2004; 153(1): 77-86[DOI][PubMed]
  • 11. Zargari A. Medicine herbs. 1993;
  • 12. Namvaran-Abbas-Abad A, Khayat-Nouri MH. Interactions between Matricaria recutita and cisplatin on PTZ-induced seizure threshold in mice. Feyz J Kashan Univ Med Sci. 2011; 15(3)
  • 13. Vakili A, Sharifat S, Akhavan MM, Bandegi AR. Effect of lavender oil (Lavandula angustifolia) on cerebral edema and its possible mechanisms in an experimental model of stroke. Brain Res. 2014; 1548: 56-62[DOI][PubMed]
  • 14. Rabiei Z, Rafieian-Kopaei M, Heidarian E, Saghaei E, Mokhtari S. Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus Basalis of Meynert in rat. Neurochem Res. 2014; 39(2): 353-60[DOI][PubMed]
  • 15. Naseri MKG. Effect of Zataria multiflora Boiss leaf hydroalcoholic extract on rat ileum. J Kermanshah Univ Med Sci. 2003; 7(3)
  • 16. Rabiei Z, Rafieian M. Effects of Zizyphus jujuba extract on motor coordination impairment induced by bilateral electric lesions of the nucleus basalis of meynert in rat. Physiol Pharmacol. 2014; 17(4): 469-77
  • 17. Singh O, Khanam Z, Misra N, Srivastava MK. Chamomile (Matricaria chamomilla L.): An overview. Pharmacogn Rev. 2011; 5(9): 82-95[DOI][PubMed]
  • 18. Sofiabadi M, Esmaeili MH, Haghdost Yazdy H, Azhdari Zarmehri H. The effect of intraperitoneally injection of Matricaria Chamomilla ethanolic extract on seizure. J Med Plants. 2012; 4(44): 86-92
  • 19. Arzi A, Kesmati M, Alikhany M. Preventive effect of hydroalcoholic extract of Matricaria Chamomilla on Nicotine induced convulsions in mice. J Babol Univ Med Sci. 2004; 6: 12-7
  • 20. Hasanein P, Shahidi S. Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats. Med Sci Monit. 2012; 18(1)-6[PubMed]
  • 21. Orhan I, Aslan M. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. J Ethnopharmacol. 2009; 122(2): 327-32[DOI][PubMed]
  • 22. Alibabaei Z, Rabiei Z, Rahnama S, Mokhtari S, Rafieian-kopaei M. Matricaria Chamomilla extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Biomed Aging Pathol. 2014; 4(4): 355-60[DOI]
  • 23. Bora KS, Arora S, Shri R. Role of Ocimum basilicum L. in prevention of ischemia and reperfusion-induced cerebral damage, and motor dysfunctions in mice brain. J Ethnopharmacol. 2011; 137(3): 1360-5[DOI][PubMed]
  • 24. Asgharzade S, Rabiei Z, Rafieian-Kopaei M. Effects of Matricaria chamomilla extract on motor coordination impairment induced by scopolamine in rats. Asian Pac J Trop Biomed. 2015; 5(10): 829-33[DOI]
  • 25. Calapai G, Squadrito F, Rizzo A, Crisafulli C, Campo GM, Marciano MC, et al. A new antioxidant drug limits brain damage induced by transient cerebral ischaemia. Drugs Exp Clin Res. 1993; 19(4): 159-64[PubMed]
  • 26. Cruz R, Almaguer Melian W, Bergado Rosado JA. [Glutathione in cognitive function and neurodegeneration]. Rev Neurol. 2003; 36(9): 877-86[PubMed]
  • 27. Mansouri SMT, Naghizadeh B, Hosseinzadeh H. The effect of Pistacia vera L. gum extract on oxidative damage during experimental cerebral ischemia-reperfusion in rats. Iran Biomed J. 2005; 9(4): 181-5
  • 28. Jacobs TP, Kempski O, McKinley D, Dutka AJ, Hallenbeck JM, Feuerstein G. Blood flow and vascular permeability during motor dysfunction in a rabbit model of spinal cord ischemia. Stroke. 1992; 23(3): 367-73[DOI]
  • 29. Chandrashekhar VM, Ranpariya VL, Ganapaty S, Parashar A, Muchandi AA. Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats. J Ethnopharmacol. 2010; 127(3): 645-51[DOI][PubMed]
  • 30. McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res. 2006; 20(7): 519-30[DOI][PubMed]
  • 31. Karbalay-Doust S, Noorafshan A. Antiulcerogenic effects of Matricaria chamomilla extract in experimental gastric ulcer in mice. Iran J Med Sci. 2015; 34(3): 198-203
  • 32. Lo EH, Wang X, Cuzner ML. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J Neurosci Res. 2002; 69(1): 1-9[DOI][PubMed]
  • 33. Cho JY, Kim IS, Jang YH, Kim AR, Lee SR. Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Neurosci Lett. 2006; 404(3): 330-5[DOI][PubMed]
  • 34. Ha SK, Lee P, Park JA, Oh HR, Lee SY, Park JH, et al. Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model. Neurochem Int. 2008; 52(4-5): 878-86[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments