Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Microsatellite Instability Markers Status in Colorectal Cancer

Giti Esmailnia 1 , Mahdi Montazer Haghighi 2 , * , Gholamreza Javadi 1 , Kazem Parivar 1 and Mohammadreza Zali 3
Authors Information
1 Department of Biology, Faculty of Sciences, Science And Research Branch, Islamic Azad University, Tehran, Iran
2 Department of Biology, Faculty of Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran
3 Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: December 28, 2014, 16 (12); 26-30
  • Published Online: September 25, 2013
  • Article Type: Research Article
  • Received: January 22, 2013
  • Accepted: March 6, 2013

To Cite: Esmailnia G, Montazer Haghighi M, Javadi G, Parivar K, Zali M. Microsatellite Instability Markers Status in Colorectal Cancer, Zahedan J Res Med Sci. 2014 ; 16(12):26-30.

Copyright © 2014 Zahedan University of Medical Sciences. All rights reserved.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Materials and Methods
  • 1. Ansari R, Mahdavinia M, Sadjadi A, Nouraie M, Kamangar F, Bishehsari F, et al. Incidence and age distribution of colorectal cancer in Iran: results of a population-based cancer registry. Cancer Lett. 2006; 240(1): 143-7[DOI][PubMed]
  • 2. Ashktorab H, Smoot DT, Carethers JM, Rahmanian M, Kittles R, Vosganian G, et al. High incidence of microsatellite instability in colorectal cancer from African Americans. Clin Cancer Res. 2003; 9(3): 1112-7[PubMed]
  • 3. Ashktorab H, Smoot DT, Farzanmehr H, Fidelia-Lambert M, Momen B, Hylind L, et al. Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. Int J Cancer. 2005; 116(6): 914-9[DOI][PubMed]
  • 4. Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, et al. Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. Dig Dis Sci. 2008; 53(10): 2723-31[DOI][PubMed]
  • 5. Azadeh S, Moghimi-Dehkordi B, Fatem SR, Pourhoseingholi MA, Ghiasi S, Zali MR. Colorectal cancer in Iran: an epidemiological study. Asian Pac J Cancer Prev. 2008; 9(1): 123-6[PubMed]
  • 6. Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomaki P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med. 1998; 338(21): 1481-7[DOI][PubMed]
  • 7. Abbaszadegan MR, Tavasoli A, Velayati A, Sima HR, Vosooghinia H, Farzadnia M, et al. Stool-based DNA testing, a new noninvasive method for colorectal cancer screening, the first report from Iran. World J Gastroenterol. 2007; 13(10): 1528-33[PubMed]
  • 8. Aebi S, Kurdi-Haidar B, Gordon R, Cenni B, Zheng H, Fink D, et al. Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res. 1996; 56(13): 3087-90[PubMed]
  • 9. Al-Sukhni W, Aronson M, Gallinger S. Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. Surg Clin North Am. 2008; 88(4): 819-44[DOI][PubMed]
  • 10. Malekzadeh R, Bishehsari F, Mahdavinia M, Ansari R. Epidemiology and molecular genetics of colorectal cancer in iran: a review. Arch Iran Med. 2009; 12(2): 161-9[PubMed]
  • 11. Moslein G, Tester DJ, Lindor NM, Honchel R, Cunningham JM, French AJ, et al. Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. Hum Mol Genet. 1996; 5(9): 1245-52[PubMed]
  • 12. Mousavi SM, Gouya MM, Ramazani R, Davanlou M, Hajsadeghi N, Seddighi Z. Cancer incidence and mortality in Iran. Ann Oncol. 2009; 20(3): 556-63[DOI][PubMed]
  • 13. Notarnicola M, Gristina R, Messa C. Oestrogen receptors and microsatellite instability in colorectal carcinoma patients. Cancer Lett. 2001; 168(1): 65-70[DOI]
  • 14. Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003; 349(3): 247-57[DOI][PubMed]
  • 15. Berginc G, Bracko M, Ravnik-Glavac M, Glavac D. Screening for germline mutations of MLH1, MSH2, MSH6 and PMS2 genes in Slovenian colorectal cancer patients: implications for a population specific detection strategy of Lynch syndrome. Fam Cancer. 2009; 8(4): 421-9[DOI][PubMed]
  • 16. Berginc G, Glavac D. Rapid and accurate approach for screening of microsatellite unstable tumours using quasimonomorphic mononucleotide repeats and denaturating high performance liquid chromatography (DHPLC). Dis Markers. 2009; 26(1): 19-26[DOI][PubMed]
  • 17. Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010; 138(6): 2073-2087 e3[DOI][PubMed]
  • 18. Brennetot C, Buhard O, Jourdan F, Flejou JF, Duval A, Hamelin R. Mononucleotide repeats BAT-26 and BAT-25 accurately detect MSI-H tumors and predict tumor content: implications for population screening. Int J Cancer. 2005; 113(3): 446-50[DOI][PubMed]
  • 19. Buhard O, Suraweera N, Lectard A, Duval A, Hamelin R. Quasimonomorphic mononucleotide repeats for high-level microsatellite instability analysis. Dis Markers. 2004; 20(4-5): 251-7[PubMed]
  • 20. Domanska K, Carlsson C, Bendahl PO, Nilbert M. Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels. BMC Med Genet. 2009; 10: 30[DOI][PubMed]
  • 21. Haghighi MM, Javadi GR, Parivar K, Milanizadeh S, Zali N, Fatemi SR, et al. Frequent MSI mononucleotide markers for diagnosis of hereditary nonpolyposis colorectal cancer. Asian Pac J Cancer Prev. 2010; 11(4): 1033-5[PubMed]
  • 22. Haghighi MM, Vahedi M, Mohebbi SR, Pourhoseingholi MA, Fatemi SR, Zali MR. Comparison of survival between patients with hereditary non polyposis colorectal cancer (HNPCC) and sporadic colorectal cancer. Asian Pac J Cancer Prev. 2009; 10(3): 497-500[PubMed]
  • 23. Moghimi-Dehkordi B, Safaee A, Zali MR. Prognostic factors in 1,138 Iranian colorectal cancer patients. Int J Colorectal Dis. 2008; 23(7): 683-8[DOI][PubMed]
  • 24. Pastrello C, Baglioni S, Tibiletti MG, Papi L, Fornasarig M, Morabito A, et al. Stability of BAT26 in tumours of hereditary nonpolyposis colorectal cancer patients with MSH2 intragenic deletion. Eur J Hum Genet. 2006; 14(1): 63-8[DOI][PubMed]
  • 25. Soreide K. Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers--ready for prime time? Tumour Biol. 2007; 28(5): 290-300[DOI][PubMed]
  • 26. Soreide K. High-fidelity of five quasimonomorphic mononucleotide repeats to high-frequency microsatellite instability distribution in early-stage adenocarcinoma of the colon. Anticancer Res. 2011; 31(3): 967-71[PubMed]
  • 27. Sadjadi A, Malekzadeh R, Derakhshan MH, Sepehr A, Nouraie M, Sotoudeh M, et al. Cancer occurrence in Ardabil: results of a population-based cancer registry from Iran. Int J Cancer. 2003; 107(1): 113-8[DOI][PubMed]
  • 28. Sadjadi A, Nouraie M, Mohagheghi MA, Mousavi-Jarrahi A, Malekezadeh R, Parkin DM. Cancer occurrence in Iran in 2002, an international perspective. Asian Pac J Cancer Prev. 2005; 6(3): 359-63[PubMed]
  • 29. Sinicrope F, Foster NR, Sargent DJ, Thibodeau SN, Smyrk TC, O'Connell MJ, et al. Model-based prediction of defective DNA mismatch repair using clinicopathological variables in sporadic colon cancer patients. Cancer. 2010; 116(7): 1691-8[DOI][PubMed]
  • 30. Slattery ML, Potter JD, Curtin K, Edwards S, Ma KN, Anderson K, et al. Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer. Cancer Res. 2001; 61(1): 126-30[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments