Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

The Effects of Quercetin and Retinoic acid on Skeletal System of Rat Embryos in Prenatal Period

Nahid Gohari-Behbahani 1 , Mahmood Khaksary-Mahabady 1 , * , Reza Ranjbar 1 , Hossein Najafzadeh-Varzi 2 and Babak Mohammadian 3
Authors Information
1 Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 Department of Pathology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: February 8, 2014, 16 (12); 31-36
  • Published Online: December 15, 2014
  • Article Type: Research Article
  • Received: September 29, 2013
  • Accepted: December 11, 2013

To Cite: Gohari-Behbahani N, Khaksary-Mahabady M, Ranjbar R, Najafzadeh-Varzi H, Mohammadian B. The Effects of Quercetin and Retinoic acid on Skeletal System of Rat Embryos in Prenatal Period, Zahedan J Res Med Sci. 2014 ; 16(12):31-36.

Abstract
Copyright © 2014 Zahedan University of Medical Sciences. All rights reserved.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Introduction
Results
Discussion
Acknowledgements
Footnotes
References
  • 1. Duester G. Retinoic acid synthesis and signaling during early organogenesis. Cell. 2008; 134(6): 921-31[DOI][PubMed]
  • 2. Maden M. Retinoids and spinal cord development. J Neurobiol. 2006; 66(7): 726-38[DOI][PubMed]
  • 3. Ross SA, McCaffery PJ, Drager UC, De Luca LM. Retinoids in embryonal development. Physiol Rev. 2000; 80(3): 1021-54[PubMed]
  • 4. Kam RK, Deng Y, Chen Y, Zhao H. Retinoic acid synthesis and functions in early embryonic development. Cell Biosci. 2012; 2(1): 11[DOI][PubMed]
  • 5. Ali-Khan SE, Hales BF. Novel retinoid targets in the mouse limb during organogenesis. Toxicol Sci. 2006; 94(1): 139-52[DOI][PubMed]
  • 6. Zile MH. Vitamin A and embryonic development: An overview. J Nutr. 1998; 128(2): 455-8
  • 7. Mark M, Ghyselinck NB, Chambon P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol. 2006; 46: 451-80[DOI][PubMed]
  • 8. Rial E, Gonzalez-Barroso M, Fleury C, Iturrizaga S, Sanchis D, Jimenez-Jimenez J, et al. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2. EMBO J. 1999; 18(21): 5827-33[DOI][PubMed]
  • 9. Notario B, Zamora M, Vinas O, Mampel T. All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition. Mol Pharmacol. 2003; 63(1): 224-31[PubMed]
  • 10. Huxley RR, Neil HA. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Eur J Clin Nutr. 2003; 57(8): 904-8[DOI][PubMed]
  • 11. Goldberg DM, Hahn SE, Parkes JG. Beyond alcohol: beverage consumption and cardiovascular mortality. Clin Chim Acta. 1995; 237(1-2): 155-87[PubMed]
  • 12. Perez Vizcaino F, Duarte J, Jimenez R. Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep. 2009; 61(1): 67-75
  • 13. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008; 585(2-3): 325-37[DOI][PubMed]
  • 14. Maciel RM, Costa MM, Martins DB, Franca RT, Schmatz R, Graca DL, et al. Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats. Res Vet Sci. 2013; 95(2): 389-97[DOI][PubMed]
  • 15. Sanhueza J, Valdes J, Campos R, Garrido A, Valenzuela A. Changes in the xanthine dehydrogenase/xanthine oxidase ratio in the rat kidney subjected to ischemia-reperfusion stress: preventive effect of some flavonoids. Res Commun Chem Pathol Pharmacol. 1992; 78(2): 211-8[PubMed]
  • 16. Robak J, Gryglewski RJ. Flavonoids are scavengers of superoxide anions. Biochem Pharmacol. 1988; 37(5): 837-41[DOI]
  • 17. Chang WS, Lee YJ, Lu FJ, Chiang HC. Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Res. 1993; 13(6A): 2165-70[PubMed]
  • 18. Tauber AI, Fay JR, Marletta MA. Flavonoid inhibition of the human neutrophil NADPH-oxidase. Biochem Pharmacol. 1984; 33(8): 1367-9[PubMed]
  • 19. Kimmel CA, Trammell C. A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals. Stain Technol. 1981; 56(5): 271-3[PubMed]
  • 20. Soprano DR, Gyda M3, Jiang H, Harnish DC, Ugen K, Satre M, et al. A sustained elevation in retinoic acid receptor-beta 2 mRNA and protein occurs during retinoic acid-induced fetal dysmorphogenesis. Mech Dev. 1994; 45(3): 243-53[PubMed]
  • 21. Mulder GB, Manley N, Grant J, Schmidt K, Zeng W, Eckhoff C, et al. Effects of excess vitamin A on development of cranial neural crest-derived structures: a neonatal and embryologic study. Teratology. 2000; 62(4): 214-26[DOI][PubMed]
  • 22. Kistler A. Teratogenesis of retinoic acid in rats: susceptible stages and suppression of retinoic acid-induced limb malformations by cycloheximide. Teratology. 1981; 23(1): 25-31[DOI][PubMed]
  • 23. Tom C, Juriloff DM, Harris MJ. Studies of the effect of retinoic acid on anterior neural tube closure in mice genetically liable to exencephaly. Teratology. 1991; 43(1): 27-40[DOI][PubMed]
  • 24. Dorko F, Spakovska T, Lovasova K, Patlevic P, Kluchova D. NADPH-d activity in rat thymus after the application of retinoid acid. Eur J Histochem. 2012; 56(1)[DOI][PubMed]
  • 25. Emmanouil-Nikoloussi EN, Goret-Nicaise M, Foroglou CH, Katsarma E, Dhem A, Dourov N, et al. Craniofacial abnormalities induced by retinoic acid: a preliminary histological and scanning electron microscopic (SEM) study. Exp Toxicol Pathol. 2000; 52(5): 445-53[PubMed]
  • 26. Mahmood R, Flanders KC, Morriss-Kay GM. Interactions between retinoids and TGF beta s in mouse morphogenesis. Development. 1992; 115(1): 67-74[PubMed]
  • 27. Hansen LA, Pearl GS. Isotretinoin teratogenicity. Case report with neuropathologic findings. Acta Neuropathol. 1985; 65(3-4): 335-7[PubMed]
  • 28. Pauken CM, LaBorde JB, Bolon B. Retinoic acid acts during peri-implantational development to alter axial and brain formation. Anat Embryol (Berl). 1999; 200(6): 645-55[PubMed]
  • 29. Rutledge JC, Shourbaji AG, Hughes LA, Polifka JE, Cruz YP, Bishop JB, et al. Limb and lower-body duplications induced by retinoic acid in mice. Proc Natl Acad Sci U S A. 1994; 91(12): 5436-40[PubMed]
  • 30. Colakoglu N, Kukner A. Teratogenicity of retinoic acid and its effects on TGF-beta2 expression in the developing cerebral cortex of the rat. J Mol Histol. 2004; 35(8-9): 823-7[DOI][PubMed]
  • 31. Prater MR, Laudermilch CL, Liang C, Holladay SD. Placental oxidative stress alters expression of murine osteogenic genes and impairs fetal skeletal formation. Placenta. 2008; 29(9): 802-8[DOI][PubMed]
  • 32. Song Y, Liu J, Zhang F, Zhang J, Shi T, Zeng Z. Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway. Life Sci. 2013; 92(24-26): 1215-21[DOI][PubMed]
  • 33. Gupta C, Vikram A, Tripathi DN, Ramarao P, Jena GB. Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat. Phytother Res. 2010; 24(1): 119-28[DOI][PubMed]
  • 34. Sanders RA, Rauscher FM, Watkins J3. Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 2001; 15(3): 143-9[PubMed]
  • 35. Morales AI, Vicente-Sanchez C, Sandoval JM, Egido J, Mayoral P, Arevalo MA, et al. Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Food Chem Toxicol. 2006; 44(12): 2092-100[DOI][PubMed]
  • 36. Perez-Pasten R, Martinez-Galero E, Chamorro-Cevallos G. Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea. J Pharm Pharmacol. 2010; 62(8): 1003-9[DOI][PubMed]
  • 37. Liang C, Oest ME, Jones JC, Prater MR. Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation. Birth Defects Res B Dev Reprod Toxicol. 2009; 86(5): 362-9[DOI][PubMed]
  • 38. Abdelmoaty MA, Ibrahim MA, Ahmed NS, Abdelaziz MA. Confirmatory studies on the antioxidant and antidiabetic effect of quercetin in rats. Indian J Clin Biochem. 2010; 25(2): 188-92[DOI][PubMed]
  • 39. Dwivedi N, Flora SJS. Dose dependent efficacy of quercetin in preventing arsenic induced oxidative stress in rat blood and liver. J Cell Tissue Res. 2011; 11(1): 2505-611
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