Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Reversal Effect of Coriandrum sativum Leaves Extract on Learning and Memory Deficits Induced by Epilepsy in Male Rat

Mahmoud Elahdadi-Salmani 1 , * , Mahdi Khorshidi 1 and Jamile Ozbaki 1
Authors Information
1 Institute of Biological Sciences, Faculty of Biology, Damghan University, Damghan, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: March 28, 2015, 17 (3)
  • Published Online: March 1, 2015
  • Article Type: Research Article
  • Received: January 15, 2014
  • Accepted: February 28, 2014
  • DOI: 10.17795/zjrms1279

To Cite: Elahdadi-Salmani M, Khorshidi M, Ozbaki J. Reversal Effect of Coriandrum sativum Leaves Extract on Learning and Memory Deficits Induced by Epilepsy in Male Rat, Zahedan J Res Med Sci. 2015 ; 17(3):-. doi: 10.17795/zjrms1279.

Copyright © 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
  • 1. Baxendale S. Amnesia in temporal lobectomy patients: historical perspective and review. Seizure. 1998; 7(1): 15-24[DOI][PubMed]
  • 2. Baxendale SA. The hippocampus: functional and structural correlations. Seizure. 1995; 4(2): 105-17[DOI][PubMed]
  • 3. Aldenkamp A, Arends J. The relative influence of epileptic EEG discharges, short nonconvulsive seizures, and type of epilepsy on cognitive function. Epilepsia. 2004; 45(1): 54-63[DOI][PubMed]
  • 4. Dodrill CB. Neuropsychological effects of seizures. Epilepsy Behav. 2004; 5 Suppl 1-4[PubMed]
  • 5. Helmstaedter C, Kurthen M. Memory and epilepsy: characteristics, course, and influence of drugs and surgery. Curr Opin Neurol. 2001; 14(2): 211-6[DOI][PubMed]
  • 6. Helmstaedter C, Kurthen M, Lux S, Reuber M, Elger CE. Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy. Ann Neurol. 2003; 54(4): 425-32[DOI][PubMed]
  • 7. Soria C, Callu D, Viguier D, El Sabbagh S, Bulteau C, Laroussinie F, et al. Parental report of cognitive difficulties, quality of life and rehabilitation in children with epilepsy or treated for brain tumour. Dev Neurorehabil. 2008; 11(4): 268-75[DOI][PubMed]
  • 8. Aldenkamp AP, Bodde N. Behaviour, cognition and epilepsy. Acta Neurol Scand Suppl. 2005; 182: 19-25[DOI][PubMed]
  • 9. Elger CE, Helmstaedter C, Kurthen M. Chronic epilepsy and cognition. Lancet Neurol. 2004; 3(11): 663-72[DOI][PubMed]
  • 10. Motamedi G, Meador K. Epilepsy and cognition. Epilepsy Behav. 2003; 4 Suppl 2-38[PubMed]
  • 11. Kohr G. NMDA receptor antagonists: tools in neuroscience with promise for treating CNS pathologies. J Physiol. 2007; 581: 1-2[DOI][PubMed]
  • 12. Hermann BP, Seidenberg M, Schoenfeld J, Davies K. Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy. Arch Neurol. 1997; 54(4): 369-76[PubMed]
  • 13. Meador KJ, Loring DW, Ray PG, Murro AM, King DW, Perrine KR, et al. Differential cognitive and behavioral effects of carbamazepine and lamotrigine. Neurology. 2001; 56(9): 1177-82[PubMed]
  • 14. Chauviere L, Rafrafi N, Thinus-Blanc C, Bartolomei F, Esclapez M, Bernard C. Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy. J Neurosci. 2009; 29(17): 5402-10[DOI][PubMed]
  • 15. Frisch C, Kudin AP, Elger CE, Kunz WS, Helmstaedter C. Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. Epilepsy Res. 2007; 73(2): 173-80[DOI][PubMed]
  • 16. Zhang Y, Cai GE, Yang Q, Lu QC, Li ST, Ju G. Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model. Epilepsy Behav. 2010; 17(4): 448-54[DOI][PubMed]
  • 17. Szyndler J, Piechal A, Blecharz-Klin K, Skorzewska A, Maciejak P, Walkowiak J, et al. Effect of kindled seizures on rat behavior in water Morris maze test and amino acid concentrations in brain structures. Pharmacol Rep. 2006; 58(1): 75-82[PubMed]
  • 18. Mehla J, Reeta KH, Gupta P, Gupta YK. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci. 2010; 87(19-22): 596-603[DOI][PubMed]
  • 19. Gayoso MJ, Primo C, al-Majdalawi A, Fernandez JM, Garrosa M, Iniguez C. Brain lesions and water-maze learning deficits after systemic administration of kainic acid to adult rats. Brain Res. 1994; 653(1-2): 92-100[DOI][PubMed]
  • 20. Bhuiyan MI, Begum J, Sultana M. Chemical composition of leaf and seed essential oil of Coriandrum sativum L. from Bangladesh. Bangladesh J Pharmacol. 2009; 4(2)[DOI]
  • 21. Gray AM, Flatt PR. Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). Br J Nutr. 1999; 81(3): 203-9[DOI][PubMed]
  • 22. Jabeen Q, Bashir S, Lyoussi B, Gilani AH. Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. J Ethnopharmacol. 2009; 122(1): 123-30[DOI][PubMed]
  • 23. Duke JA, Bogenschutz-Godwin M, duCelliar J. Handbook of medicinal herbs. 2002; [DOI]
  • 24. Bhattachacharjee SK. Handbook of medicinal plants. 2001;
  • 25. Mani V, Parle M. Memory-enhancing activity of Coriandrum sativum in rats. Pharmacologyonline. 2009; 2: 827-39
  • 26. Mani V, Parle M, Ramasamy K, Abdul Majeed AB. Reversal of memory deficits by Coriandrum sativum leaves in mice. J Sci Food Agric. 2011; 91(1): 186-92[DOI][PubMed]
  • 27. Detour J, Schroeder H, Desor D, Nehlig A. A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats. Epilepsia. 2005; 46(4): 499-508[DOI][PubMed]
  • 28. Inostroza M, Cid E, Brotons-Mas J, Gal B, Aivar P, Uzcategui YG, et al. Hippocampal-dependent spatial memory in the water maze is preserved in an experimental model of temporal lobe epilepsy in rats. PLoS One. 2011; 6(7)[DOI][PubMed]
  • 29. Dhume RA, Nagwekar MD, Noronha A, Varde MR, Mascarenhas JF. Four-arm radial open maze (FAROM) as a tool for assessing the effect of atropine in spatial memory of the rats. Indian J Physiol Pharmacol. 1989; 33(1): 1-9[PubMed]
  • 30. Garcia-Cairasco N, Wakamatsu H, Oliveira JA, Gomes EL, Del Bel EA, Mello LE. Neuroethological and morphological (Neo-Timm staining) correlates of limbic recruitment during the development of audiogenic kindling in seizure susceptible Wistar rats. Epilepsy Res. 1996; 26(1): 177-92[DOI][PubMed]
  • 31. Peredery O, Persinger MA, Blomme C, Parker G. Absence of maternal behavior in rats with lithium/pilocarpine seizure-induced brain damage: support of MacLean's triune brain theory. Physiol Behav. 1992; 52(4): 665-71[DOI][PubMed]
  • 32. Tome Ada R, Feitosa CM, Freitas RM. Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? Arq Neuropsiquiatr. 2010; 68(4): 579-85[PubMed]
  • 33. Cioanca O, Hritcu L, Mihasan M, Hancianu M. Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid beta(1-42) rat model of Alzheimer's disease. Physiol Behav. 2013; 120: 193-202[DOI][PubMed]
  • 34. Joshi H, Parle M. Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn. J Med Food. 2006; 9(3): 413-7[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments