Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Hasan Namdar Ahmadabad 1 , * , Morteza Behnamfar 2 , Maryam Nezafat Firizi 1 , Sahar Saghayan 2 , Fatemeh Taghasi 2 and Alireza Abbaspur 3
Authors Information
1 Department of Pathobiology and Medical Laboratory Science, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
2 Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3 Department of Molecular Science, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: October 2017, 19 (10); e12965
  • Published Online: October 31, 2017
  • Article Type: Research Article
  • Received: May 10, 2017
  • Revised: July 2, 2017
  • Accepted: October 28, 2017
  • DOI: 10.5812/zjrms.12965

To Cite: Namdar Ahmadabad H, Behnamfar M, Nezafat Firizi M, Saghayan S, Taghasi F, et al. Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro, Zahedan J Res Med Sci. 2017 ; 19(10):e12965. doi: 10.5812/zjrms.12965.

Abstract
Copyright © 2017, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnotes
References
  • 1. Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011; 19(5): 245-54[DOI][PubMed]
  • 2. El-Kott AF, Bin-Meferij MM. Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats. Curr Ther Res Clin Exp. 2015; 77: 73-8[DOI][PubMed]
  • 3. Lin CC, Lu JM, Yang JJ, Chuang SC, Ujiie T. Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med. 1996; 24(2): 127-37[DOI][PubMed]
  • 4. Yu BS, Yan XP, Xiong J, Xin Q. Simultaneous determination of chlorogenic acid, forsythin and arctiin in Chinese traditional medicines preparation by reversed phase-HPLC. Chem Pharm Bull (Tokyo). 2003; 51(4): 421-4[PubMed]
  • 5. Tamayo C, Richardson MA, Diamond S, Skoda I. The chemistry and biological activity of herbs used in Flor-Essence herbal tonic and Essiac. Phytother Res. 2000; 14(1): 1-14[PubMed]
  • 6. Gentil M, Pereira JV, Sousa YT, Pietro R, Neto MD, Vansan LP, et al. In vitro evaluation of the antibacterial activity of Arctium lappa as a phytotherapeutic agent used in intracanal dressings. Phytother Res. 2006; 20(3): 184-6[DOI][PubMed]
  • 7. Wang BS, Yen GC, Chang LW, Yen WJ, Duh PD. Protective effects of burdock (Arctium lappa Linne) on oxidation of low-density lipoprotein and oxidative stress in RAW 264.7 macrophages. Food Chem. 2007; 101(2): 729-38
  • 8. Knipping K, van Esch EC, Wijering SC, van der Heide S, Dubois AE, Garssen J. In vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood). 2008; 233(11): 1469-77[DOI][PubMed]
  • 9. Liu C, Srivastava KD, Yang N, Primas MA, Bushko R, Chin K, et al. Arctigenin isolated from Arctium lappa L. Inhibits ige production. J Allergy Clin Immunol. 2016; 137(2)
  • 10. Miyamoto K, Nomura M, Sasakura M, Matsui E, Koshiura R, Murayama T, et al. Antitumor activity of oenothein B, a unique macrocyclic ellagitannin. Jpn J Cancer Res. 1993; 84(1): 99-103[PubMed]
  • 11. Park SY, Hong SS, Han XH, Hwang JS, Lee D, Ro JS, et al. Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production. Chem Pharm Bull (Tokyo). 2007; 55(1): 150-2[PubMed]
  • 12. Bhat SH, Azmi AS, Hadi SM. Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties. Toxicol Appl Pharmacol. 2007; 218(3): 249-55[DOI][PubMed]
  • 13. Ferracane R, Graziani G, Gallo M, Fogliano V, Ritieni A. Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves. J Pharm Biomed Anal. 2010; 51(2): 399-404[DOI][PubMed]
  • 14. Liu S, Chen K, Schliemann W, Strack D. Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS. Phytochem Anal. 2005; 16(2): 86-9[DOI][PubMed]
  • 15. Bibak B, Gharib FG, Daneshmandi S, Abbaspour AR, Firizi MN, Ahmadabad HN. The immunomodulatory effects of abortion-prone mice decidual and serum soluble factors on macrophages and splenocytes. Eur J Obstet Gynecol Reprod Biol. 2012; 165(2): 331-6[DOI][PubMed]
  • 16. Ahmadabad HN, Hassan ZM, Safari E, Bozorgmehr M, Ghazanfari T, Moazzeni SM. Evaluation of the immunomodulatory effect of the 14 kDa protein isolated from aged garlic extract on dendritic cells. Cell Immunol. 2011; 269(2): 90-5[DOI][PubMed]
  • 17. Matsumoto T, Hosono-Nishiyama K, Yamada H. Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. Planta Med. 2006; 72(3): 276-8[DOI][PubMed]
  • 18. Tsai WJ, Chang CT, Wang GJ, Lee TH, Chang SF, Lu SC, et al. Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes. Chin Med. 2011; 6(1): 12[DOI][PubMed]
  • 19. Hirahara K, Nakayama T. CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int Immunol. 2016; 28(4): 163-71[DOI][PubMed]
  • 20. Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, et al. Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa L. Clin Mol Allergy. 2011; 9(1): 4[DOI][PubMed]
  • 21. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol. 2003; 42(6): 472-3[PubMed]
  • 22. Rodriguez P, Blanco J, Juste S, Garces M, Perez R, Alonso L, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis. 1995; 33(2): 134-5[PubMed]
  • 23. Lo Faro ML, Fox B, Whatmore JL, Winyard PG, Whiteman M. Hydrogen sulfide and nitric oxide interactions in inflammation. Nitric Oxide. 2014; 41: 38-47[DOI][PubMed]
  • 24. Sharma JN, Al-Omran A, Parvathy SS. Role of nitric oxide in inflammatory diseases. Inflammopharmacology. 2007; 15(6): 252-9[DOI][PubMed]
  • 25. Kim BH, Hong SS, Kwon SW, Lee HY, Sung H, Lee IJ, et al. Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of nuclear factor-kappaB in macrophages. J Pharmacol Exp Ther. 2008; 327(2): 393-401[DOI][PubMed]
  • 26. Cho MK, Park JW, Jang YP, Kim YC, Kim SG. Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation in macrophages. Int Immunopharmacol. 2002; 2(1): 105-16
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