Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Effects of Methamphetamine on Pituitary Gonadal Axis and Spermatogenesis in Mature Male Rats

Malihe Heidari-Rarani 1 , * , Ali Noori 2 and Arash Ghodousi 3
Authors Information
1 Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2 Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
3 Faculty of Nursing and Midwifery, Khorasgan Branch, Islamic Azad University, Isfahan, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: December 28, 2014, 16 (12); 37-42
  • Published Online: October 15, 2013
  • Article Type: Research Article
  • Received: June 16, 2013
  • Accepted: July 17, 2013

To Cite: Heidari-Rarani M, Noori A, Ghodousi A. Effects of Methamphetamine on Pituitary Gonadal Axis and Spermatogenesis in Mature Male Rats, Zahedan J Res Med Sci. 2014 ; 16(12):37-42.

Abstract
Copyright © 2014 Zahedan University of Medical Sciences. All rights reserved.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
Footnotes
References
  • 1. Faria R, Magalhaes A, Monteiro PR, Gomes-Da-Silva J, Amelia Tavares M, Summavielle T. MDMA in adolescent male rats: decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test. Ann N Y Acad Sci. 2006; 1074: 643-9[DOI][PubMed]
  • 2. Hesami Z, Khatamsaz S, Mokhtari M. [The effects of ecstasy on pituitary - gonadal axis and spermatogenesis in mature male rats] Persian. Tabib-e-Shargh. 2008; 10(3): 207-18
  • 3. Sprague JE, Banks ML, Cook VJ, Mills EM. Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy). J Pharmacol Exp Ther. 2003; 305(1): 159-66[DOI][PubMed]
  • 4. Henry BL, Minassian A, Perry W. Effect of methamphetamine dependence on heart rate variability. Addict Biol. 2012; 17(3): 648-58[DOI][PubMed]
  • 5. Inoue H, Nakatome M, Terada M, Mizuno M, Ono R, Iino M, et al. Maternal methamphetamine administration during pregnancy influences on fetal rat heart development. [corrected]. Life Sci. 2004; 74(12): 1529-40[PubMed]
  • 6. Yamamoto Y, Yamamoto K. The teratogenicity of methamphetamine is influenced by housing conditions of pregnant mice. Congenit Anom. 1994; 34(4): 337-43[DOI]
  • 7. Yamamoto Y, Yamamoto K, Abiru H, Fukui Y, Shiota K. Effects of methamphetamine on rat embryos cultured in vitro. Biol Neonate. 1995; 68(1): 33-8[PubMed]
  • 8. Gerra G, Bassignana S, Zaimovic A, Moi G, Bussandri M, Caccavari R, et al. Hypothalamic-pituitary-adrenal axis responses to stress in subjects with 3,4-methylenedioxy-methamphetamine ('ecstasy') use history: correlation with dopamine receptor sensitivity. Psychiatry Res. 2003; 120(2): 115-24[PubMed]
  • 9. Lohiya NK, Mishra PK, Pathak N, Manivannan B, Bhande SS, Panneerdoss S, et al. Efficacy trial on the purified compounds of the seeds of Carica papaya for male contraception in albino rat. Reprod Toxicol. 2005; 20(1): 135-48[DOI][PubMed]
  • 10. Srikanth V, Malini T, Arunakaran J, Govindarajulu P, Balasubramanian K. Effects of ethanol treatment on epididymal secretory products and sperm maturation in albino rats. J Pharmacol Exp Ther. 1999; 288(2): 509-15[PubMed]
  • 11. Climko RP, Roehrich H, Sweeney DR, Al-Razi J. Ecstacy: a review of MDMA and MDA. Int J Psychiatry Med. 1986; 16(4): 359-72[PubMed]
  • 12. Frith CH, Chang LW, Lattin DL, Walls RC, Hamm J, Doblin R. Toxicity of methylenedioxymethamphetamine (MDMA) in the dog and the rat. Fundam Appl Toxicol. 1987; 9(1): 110-9[PubMed]
  • 13. Shaw WN. Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants. Pharmacol Biochem Behav. 1993; 46(3): 653-9[PubMed]
  • 14. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology. 1997; 138(9): 3859-63[DOI][PubMed]
  • 15. McNeilly AS, Sharpe RM, Davidson DW, Fraser HM. Inhibition of gonadotrophin secretion by induced hyperprolactinaemia in the male rat. J Endocrinol. 1978; 79(1): 59-68[PubMed]
  • 16. Fischer HS, Zernig G, Schatz DS, Humpel C, Saria A. MDMA ('ecstasy') enhances basal acetylcholine release in brain slices of the rat striatum. Eur J Neurosci. 2000; 12(4): 1385-90[PubMed]
  • 17. Knigge U, Wollesen F, Dejgaard A, Larsen K, Christiansen PM. Modulation of basal and LRH-stimulated gonadotrophin secretion by histamine in normal men. Neuroendocrinology. 1984; 38(2): 93-6[PubMed]
  • 18. Justo SN, Rossano GL, Szwarcfarb B, Rubio MC, Moguilevsky JA. Effect of serotoninergic system on FSH secretion in male and female rats: evidence for stimulatory and inhibitory actions. Neuroendocrinology. 1989; 50(4): 382-6[PubMed]
  • 19. Larsen KE, Fon EA, Hastings TG, Edwards RH, Sulzer D. Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. J Neurosci. 2002; 22(20): 8951-60[PubMed]
  • 20. Rudnick G, Wall SC. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc Natl Acad Sci U S A. 1992; 89(5): 1817-21[PubMed]
  • 21. Sharpe RM, McNeilly AS. The effect of induced hyperprolactinaemia on Leydig cell function and LH-induced loss of LH-receptors in the rat testis. Mol Cell Endocrinol. 1979; 16(1): 19-27[PubMed]
  • 22. de Kretser DM, Robertson DM. The isolation and physiology of inhibin and related proteins. Biol Reprod. 1989; 40(1): 33-47[PubMed]
  • 23. Scearce-Levie K, Viswanathan SS, Hen R. Locomotor response to MDMA is attenuated in knockout mice lacking the 5-HT1B receptor. Psychopharmacology (Berl). 1999; 141(2): 154-61[PubMed]
  • 24. Kalra SP, Kalra PS. Neural regulation of luteinizing hormone secretion in the rat. Endocr Rev. 1983; 4(4): 311-51[DOI][PubMed]
  • 25. Tsai SC, Chen JJ, Chiao YC, Lu CC, Lin H, Yeh JY, et al. The role of cyclic AMP production, calcium channel activation and enzyme activities in the inhibition of testosterone secretion by amphetamine. Br J Pharmacol. 1997; 122(5): 949-55[DOI][PubMed]
  • 26. Yamamoto Y, Yamamoto K, Hayase T. Effect of methamphetamine on male mice fertility. J Obstet Gynaecol Res. 1999; 25(5): 353-8[PubMed]
  • 27. Hurd YL, Fagergren P. Human cocaine- and amphetamine-regulated transcript (CART) mRNA is highly expressed in limbic- and sensory-related brain regions. J Comp Neurol. 2000; 425(4): 583-98[PubMed]
  • 28. Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Bourguignon JP. Cocaine and amphetamine-regulated-transcript peptide mediation of leptin stimulatory effect on the rat gonadotropin-releasing hormone pulse generator in vitro. J Neuroendocrinol. 2000; 12(5): 383-5[PubMed]
  • 29. Douglass J, McKinzie AA, Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci. 1995; 15(3 Pt 2): 2471-81[PubMed]
  • 30. Nash JJ, Meltzer HY, Gudelsky GA. Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine. J Pharmacol Exp Ther. 1988; 245(3): 873-9[PubMed]
  • 31. Tuomisto J, Mannisto P. Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev. 1985; 37(3): 249-332[PubMed]
  • 32. Yamamoto Y, Yamamoto K, Hayase T, Abiru H, Shiota K, Mori C. Methamphetamine induces apoptosis in seminiferous tubules in male mice testis. Toxicol Appl Pharmacol. 2002; 178(3): 155-60[DOI][PubMed]
  • 33. Carmen M, Manas B, Morales E. Proliferation and apoptosis of spermatogonia inpostpuberal boar (susdomesticus) testes with spontaneous unilateral and bilateral abdominal cryptorchidism. Acta Histochem. 2005; 107: 365-72
  • 34. Bernal-Manas CM, Morales E, Pastor LM, Pinart E, Bonet S, Rosa Pde L, et al. Proliferation and apoptosis of spermatogonia in postpuberal boar (Sus domesticus) testes with spontaneous unilateral and bilateral abdominal cryptorchidism. Acta Histochem. 2005; 107(5): 365-72[DOI][PubMed]
  • 35. Cadet JL, Sheng P, Ali S, Rothman R, Carlson E, Epstein C. Attenuation of methamphetamine-induced neurotoxicity in copper/zinc superoxide dismutase transgenic mice. J Neurochem. 1994; 62(1): 380-3[PubMed]
  • 36. Kempinas WD, Suarez JD, Roberts NL, Strader L, Ferrell J, Goldman JM, et al. Rat epididymal sperm quantity, quality, and transit time after guanethidine-induced sympathectomy. Biol Reprod. 1998; 59(4): 890-6[PubMed]
  • 37. Kalant H. The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs. CMAJ. 2001; 165(7): 917-28[PubMed]
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