Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Comparing the Effect of Pentoxifylline Administration on Mast Cells Maturing Process in a Diabetic and Normoglycemic Rat Wound Healing

Saeid Babaei 1 , Mohammad Bayat 2 , Bahram Kazemi 3 , Nariman Mossafa 4 , Ali Ghanbari 5 , * , Mojgan Bandepoor 3 , Fateme Fadaee 2 and Mohammad Jalili 2
Authors Information
1 Department of Anatomy, Arak University of Medical Sciences, Arak, Iran
2 Department of Biology and Anatomy, Shahid Beheshty University of Medical Sciences, Tehran, Iran
3 Cell and Molecular Biology Research Center, Shahid Beheshty University of Medical Sciences, Tehran, Iran
4 Department of Immunology, Shahid Beheshty University of Medical Sciences, Tehran, Iran
5 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: July 20, 2013, 16 (12); e23396
  • Published Online: December 15, 2014
  • Article Type: Research Article
  • Received: May 10, 2012
  • Accepted: June 5, 2012

To Cite: Babaei S, Bayat M, Kazemi B, Mossafa N, Ghanbari A, et al. Comparing the Effect of Pentoxifylline Administration on Mast Cells Maturing Process in a Diabetic and Normoglycemic Rat Wound Healing, Zahedan J Res Med Sci. 2013 ; 16(12):e23396.

Copyright © 2014 Zahedan University of Medical Sciences. All rights reserved.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Materials and Methods
  • 1. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007; 117(5): 1219-22[DOI][PubMed]
  • 2. Sebag J, Tang M, Brown S, Sadun AA, Charles MA. Effects of pentoxifylline on choroidal blood flow in nonproliferative diabetic retinopathy. Angiology. 1994; 45(6): 429-33[PubMed]
  • 3. Hebda PA, Collins MA, Tharp MD. Mast cell and myofibroblast in wound healing. Dermatol Clin. 1993; 11(4): 685-96[PubMed]
  • 4. Khoshvaghti A, Zibamanzarmofrad M, Bayat M. Effect of low-level treatment with an 80-Hz pulsed infrared diode laser on mast-cell numbers and degranulation in a rat model of third-degree burn. Photomed Laser Surg. 2011; 29(9): 597-604[DOI][PubMed]
  • 5. Zhou QG, Zheng FL, Hou FF. Inhibition of tubulointerstitial fibrosis by pentoxifylline is associated with improvement of vascular endothelial growth factor expression. Acta Pharmacol Sin. 2009; 30(1): 98-106[DOI][PubMed]
  • 6. de Campos T, Deree J, Martins JO, Loomis WH, Shenvi E, Putnam JG, et al. Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. Pancreas. 2008; 37(1): 42-9[DOI][PubMed]
  • 7. Vukovic M, Lapcevic M. [The role of pentoxifylline in nitrogen conversion in patients suffering from diabetic phlegmona of the foot]. Srp Arh Celok Lek. 2006; 134 Suppl 2: 119-21[PubMed]
  • 8. Marques LJ, Zheng L, Poulakis N, Guzman J, Costabel U. Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. Am J Respir Crit Care Med. 1999; 159(2): 508-11[DOI][PubMed]
  • 9. Aviado DM, Porter JM. Pentoxifylline: a new drug for the treatment of intermittent claudication. Mechanism of action, pharmacokinetics, clinical efficacy and adverse effects. Pharmacotherapy. 1984; 4(6): 297-307[PubMed]
  • 10. Sullivan GW, Carper HT, Novick WJ, Mandell GL. Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline. Infect Immun. 1988; 56(7): 1722-9[PubMed]
  • 11. Lin HY, Yeh CT. Controlled release of pentoxifylline from porous chitosan-pectin scaffolds. Drug Deliv. 2010; 17(5): 313-21[DOI][PubMed]
  • 12. Yessenow RS, Maves MD. The effects of pentoxifylline on random skin flap survival. Arch Otolaryngol Head Neck Surg. 1989; 115(2): 179-81[PubMed]
  • 13. Wang W, Lin S, Xiao Y, Huang Y, Tan Y, Cai L, et al. Acceleration of diabetic wound healing with chitosan-crosslinked collagen sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabetic rats. Life Sci. 2008; 82(3-4): 190-204[DOI][PubMed]
  • 14. Karasoy A KI, Turan T. The effect of pentoxifylline on the healing of full- Thickness skin defects of diabetic and normal rats. Eur J Plast Surg. 2002; 25(5): 253-7[DOI]
  • 15. Amadeu T, Braune A, Mandarim-de-Lacerda C, Porto LC, Desmouliere A, Costa A. Vascularization pattern in hypertrophic scars and keloids: a stereological analysis. Pathol Res Pract. 2003; 199(7): 469-73[DOI][PubMed]
  • 16. Andriessen MP, van Bergen BH, Spruijt KI, Go IH, Schalkwijk J, van de Kerkhof PC. Epidermal proliferation is not impaired in chronic venous ulcers. Acta Derm Venereol. 1995; 75(6): 459-62[PubMed]
  • 17. Beukelman CJ, van den Berg AJ, Hoekstra MJ, Uhl R, Reimer K, Mueller S. Anti-inflammatory properties of a liposomal hydrogel with povidone-iodine (Repithel) for wound healing in vitro. Burns. 2008; 34(6): 845-55[DOI][PubMed]
  • 18. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005; 366(9498): 1736-43[DOI][PubMed]
  • 19. LeRoy EC, Trojanowska M, Smith EA. The pathogenesis of scleroderma (systemic sclerosis, SSc). Clin Exp Rheumatol. 1991; 9(2): 173-7[PubMed]
  • 20. Trautmann A, Feuerstein B, Ernst N, Brocker EB, Klein CE. Heterotypic cell-cell adhesion of human mast cells to fibroblasts. Arch Dermatol Res. 1997; 289(4): 194-203[PubMed]
  • 21. Trautmann A, Toksoy A, Engelhardt E, Brocker EB, Gillitzer R. Mast cell involvement in normal human skin wound healing: expression of monocyte chemoattractant protein-1 is correlated with recruitment of mast cells which synthesize interleukin-4 in vivo. J Pathol. 2000; 190(1): 100-6[DOI][PubMed]
  • 22. Bayat M, Chelcheraghi F, Piryaei A, Rakhshan M, Mohseniefar Z, Rezaie F, et al. The effect of 30-day pretreatment with pentoxifylline on the survival of a random skin flap in the rat: an ultrastructural and biomechanical evaluation. Med Sci Monit. 2006; 12(6)-7[PubMed]
  • 23. LeRoy EC, Trojanowska M, Smith EA. The pathogenesis of scleroderma (systemic sclerosis, SSc). Clin Exp Rheumatol. 1991; 9(2): 173-7[PubMed]
  • 24. Kofford MW, Schwartz LB, Schechter NM, Yager DR, Diegelmann RF, Graham MF. Cleavage of type I procollagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide. J Biol Chem. 1997; 272(11): 7127-31[PubMed]
  • 25. Kameyoshi Y, Morita E, Tanaka T, Hiragun T, Yamamoto S. Interleukin-1 alpha enhances mast cell growth by a fibroblast-dependent mechanism. Arch Dermatol Res. 2000; 292(5): 240-7[PubMed]
  • 26. Conti P, Boucher W, Letourneau R, Feliciani C, Reale M, Barbacane RC, et al. Monocyte chemotactic protein-1 provokes mast cell aggregation and [3H]5HT release. Immunology. 1995; 86(3): 434-40[PubMed]
  • 27. Lin SL, Chen YM, Chien CT, Chiang WC, Tsai CC, Tsai TJ. Pentoxifylline attenuated the renal disease progression in rats with remnant kidney. J Am Soc Nephrol. 2002; 13(12): 2916-29[PubMed]
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