Effect of Glycemic Control on Homocysteine Levels in Type 2 Diabetic Patients without Cardiovascular Disease

AUTHORS

Hafez Heydari-Zarnagh 1 , * , Amireh Nejat - Shookohi 2 , Abdolrezai Nouroz 3

AUTHORS INFORMATION

1 Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran

2 Department of Clinical Biochemistry, Mashhad University of Medical Science, Mashhad, Iran

3 Department of Nutrition, MashUniversity of Medical Sciences, Mashhad, Iran

How to Cite: Heydari-Zarnagh H, Nejat - Shookohi A, Nouroz A. Effect of Glycemic Control on Homocysteine Levels in Type 2 Diabetic Patients without Cardiovascular Disease, Zahedan J Res Med Sci. 2013 ; 16(1):23-27.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 16 (1); 23-27
Published Online: May 11, 2013
Article Type: Research Article
Received: November 04, 2012
Accepted: November 10, 2012

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Abstract

Background: An increased serum homocysteine level was accepted as an important risk factor for vascular disease, including coronary atherosclerosis. However, there was no data about the importance of glycemic control on homocysteine levels in type 2 diabetic patients without CVD. The aim of this study was to investigate association between serum homocysteine concentrations and glycemic control in type 2 diabetic patients without CVD.

Patients and Methods: Out of 100 diabetic patients, 50 were good glycemic control and 50 patients were poor glycemic control. Also we tested fifty healthy volunteers as controls. Degree of glycemic control in diabetic patients was evaluated by HbA1c concentration measurements. Serum homocysteine level was measured in patients with good or poor glycemic control, and healthy controls. The correlation of HbA1c and homocysteine concentrations was investigated.

Results: The results indicated HbA1c concentration and total serum levels of homocysteine in patients as whole are significantly higher than healthy subjects. HbA1c concentration is significantly higher in subgroup with poor glycemic control compared to subgroup with good glycemic control and healthy control group. However, there is no significant difference in homocysteine serum levels of patients with good and poor glycemic control.

Conclusions: The findings suggest elevation of serum homocysteine level in patients with type 2 diabetes, however there is not significant correlation between homocysteine concentrations and glycemic control in type 2 diabetes patients.

Keywords

Glycemic control Homocysteine HbA1c Diabetes

© 0, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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