The Evaluation of Psychological Factor and Salivary Cortisol and IgA Levels in Patients with Oral Lichen Planus

AUTHORS

Tahereh Nosratzehi 1 , Fateme Arbabi-Kalati 2 , * , Saeedeh Salimi 3 , Elham Honarmand 4

AUTHORS INFORMATION

1 Department of Oral Medicine, Dental Resear ch Center, Zahedan University Of Medical Science, Faculty of Dentistry, Zahedan, Iran

2 Department of Oral Medicine, Genetics of Non-Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran

3 Department of Biochemistry, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

4 Dentist, Zahedan University of Medical Sciences, Zahedan, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 16 (7)
Published Online: February 03, 2014
Article Type: Research Article
Received: August 25, 2013
Accepted: January 15, 2014

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Oral lichen planus (OLP) is a chronic immunological disorder with unknown etiology. The aim of this study was to determine psychological factors and salivary cortisol, IgA level in patients with oral lichen planus.

Materials and Methods: In this experimental study 20 patients with OLP and healthy person were admitted to this study. Saliva samples were collected between 9-10 Am. saliva cortisol, IgA level was detected by ELIZA method. In this study, patients with anxiety and depression were measured using the SCL-90 questionnaire. Data analyzed by t-test.

Results: The mean salivary cortisol level in patients with OLP was 3.2±1.9 ng/mL and the mean saliva cortisol level in healthy person was 3.5±1.9 ng/mL. Significant difference was observed in the salivary cortisol levels in the 2 study groups (p=0.04). The mean salivary IgA level in patients with OLP was 0.69±0.29 ng/mL and the mean saliva IgA level in healthy person was 0.9±0.43 ng/mL but no significant difference was observed in the salivary cortisol levels in the 2 study groups. Results showed that anxiety levels in patients with oral lichen planus were slightly higher than controls but there was no significant difference between healthy subjects.

Conclusion: Finding revealed the mean salivary cortisol level in patient with OLP less than healthy persons. Significant difference was observed in the salivary cortisol levels in the 2 study groups. Based on the t-student test, no significant difference was observed in the salivary IgA levels in the 2 study groups. Anxiety levels in patients with oral lichen planus were slightly higher than controls.

Keywords

Cortisol Oral Lichen Planus Stress

© 0, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Fulltext

Fulltext is availale in the PDF.

References
  • 1. Refrences are available in PDF.
  • COMMENTS

    LEAVE A COMMENT HERE: