Effect of Hydroalcoholic Extract of Cinnamon on the Pituitary-Gonadal Axis in Adult Male Rats under Chemotherapy by Cyclophosphamide

AUTHORS

Touran Ghaffarie 1 , Habibollah Johari 1 , * , Mahmoud Najafian 1 , Hossein Kargar 2

1 Department of Physiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran

2 Department of Physiology, Jahrom Branch, Islamic Azad University, Jahrom, Andorra

How to Cite: Ghaffarie T, Johari H , Najafian M, Kargar H. Effect of Hydroalcoholic Extract of Cinnamon on the Pituitary-Gonadal Axis in Adult Male Rats under Chemotherapy by Cyclophosphamide, Zahedan J Res Med Sci. 2014 ; 16(3):16-20.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 16 (3); 16-20
Published Online: June 08, 2013
Article Type: Research Article
Received: November 14, 2012
Accepted: January 20, 2013

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Abstract

Background: Cyclophosphamide chemotherapy is used as anti cancer drug and weakening immune system for adult widely. As there are inadequate information, so we are to examine possible effect of hydro alcoholic extract of cinnamon on the pituitary - gonadal axis in adult male rats chemotherapy drug by cyclophosphamide.

Materils and Methods: Thirty five male Wistar rats divided into 5 groups of 7 including control, observer, and experiments 1, 2, 3, 4 and 5 respectively. The control group received no treatment while observer group were injected 2.0 mm of distilled water (solvent) intraperitoneally. The experimental mice 1, 2 and 3 were intraperitoneally injected 5 mg/kg cyclophosphamide drug with 50, 100 and 200 mg/kg fed by gavage either cinnamon extract.

Results: The weight of the rats in the experimental groups 1, 2, 3 and 4 were significantly lower than the control group (p=0.01). Right and left testicular weight in experimental groups 2 and 3 than in group 4 was significantly increased in groups 1 and 4 showed a significant decrease compared to the control group (p=0.01). Hormones LH, FSH and testosterone increased significantly in groups 2 and 3 than in group 4 showed the (p=0.05). 5 experimental groups showed significant increase in FSH compared with controls (p=0.05).

Conclusion: This study showed that cyclophosphamide has a destructive effect on testis and secretion of sex hormones in male rats and hence effect of cinnamon improves it to some extent.

Keywords

Cyclophosphamide Cinnamon LH FSH Testosterone Rat

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