The Prophylactic Effect of Vitamin C on Oxidative Stress Indexes Following Exposure to Radio Frequency Wave Generated by a BTS Antenna Model in Rat Liver and Kidne

AUTHORS

Abolfazl Akbari 1 , Gholamali Jelodar 1 , * , Saeed Nazifi 2

AUTHORS INFORMATION

1 Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

2 Department of Clinical Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

How to Cite: Akbari A, Jelodar G , Nazifi S. The Prophylactic Effect of Vitamin C on Oxidative Stress Indexes Following Exposure to Radio Frequency Wave Generated by a BTS Antenna Model in Rat Liver and Kidne, Zahedan J Res Med Sci. 2014 ; 16(2):19-23.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 16 (2); 19-23
Published Online: June 09, 2013
Article Type: Research Article
Received: March 11, 2012
Accepted: April 24, 2013

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Abstract

Background: Radio frequency wave (RFW) generated by base transceiver station (BTS) has been reported to make deleterious effects on liver and kidney, possibly through oxidative stress. This study was conducted to evaluate the effect of radiofrequency wave (RFW)-induced oxidative stress in the liver and kidney and the prophylactic effect of vitamin C on this organs by measuring the antioxidant enzymes activity including: glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), and malondialdehyde (MDA).

Materials and Methods: In this experimental study, thirty-two adult male Sprague-Dawley rats were randomly divided into four experimental groups and treated daily for 45 days as follows: control, vitamin C (L-ascorbic acid 200 mg/kg of body weight/day by gavage), test (exposed to 900MHz RFW) and the treated group (received vitamin C in addition to exposure to RFW). At the end of the experiment all animals were sacrificed and their liver and kidney were removed and were used for measurement of antioxidant enzymes and MDA activity.

Results: The results indicate that exposure to RFW in the test group decreased antioxidant enzymes activity and increased MDA compared with the control groups (p<0.05). In the treated group vitamin C improved antioxidant enzymes activity and reduced MDA compared to the test group (p<0.05).

Conclusion: It can be concluded that RFW causes oxidative stress in liver and kidney, and vitamin C improves the antioxidant enzymes activity and decreases MDA.

Keywords

Kidney Liver Oxidative Stress Radiofrequency Wave Vitamin C

© 0, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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