Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Effects of Ginger and Elaeagnus angustifolia Extracts in Symptomatic Knee Osteoarthritis

Khadijeh Rabiei 1 , Asieh Ghobadifar 2 , Mohammad Ali Ebrahimzadeh 3 , Majid Saeedi 3 and Maryam Mobini 4 , *
Authors Information
1 Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, IR Iran
2 General Physician, Mazandaran University of Medical Sciences, Sari, IR Iran
3 Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IR Iran
4 Department of Internal Medicine, Diabetes Research Center, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: November 28, 2015, 17 (11); e2200
  • Published Online: November 1, 2015
  • Article Type: Research Article
  • Received: July 15, 2014
  • Accepted: August 5, 2014
  • DOI: 10.17795/zjrms-2200

To Cite: Rabiei K, Ghobadifar A, Ebrahimzadeh M A, Saeedi M, Mobini M. Effects of Ginger and Elaeagnus angustifolia Extracts in Symptomatic Knee Osteoarthritis, Zahedan J Res Med Sci. 2015 ; 17(11):e2200. doi: 10.17795/zjrms-2200.

Copyright © 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998; 41(5): 778-99[DOI][PubMed]
  • 2. Akhtar N, Haqqi TM. Current nutraceuticals in the management of osteoarthritis: a review. Ther Adv Musculoskelet Dis. 2012; 4(3): 181-207[DOI][PubMed]
  • 3. Alishiri G, Ahmadiani A, Bayat N, Kamalinejhad M, Salimzadeh A, Saremi S. Efficacy of Elaeagnusangustifolia extract in treatment of osteoarthritis of knee: a randomized double blind placebo-controlled trial. Trauma Mon. 2007; 12(1): 49-57
  • 4. Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001; 44(11): 2531-8[PubMed]
  • 5. Bliddal H, Rosetzsky A, Schlichting P, Weidner MS, Andersen LA, Ibfelt HH, et al. A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage. 2000; 8(1): 9-12[DOI][PubMed]
  • 6. Chrubasik JE, Roufogalis BD, Chrubasik S. Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. Phytother Res. 2007; 21(7): 675-83[DOI][PubMed]
  • 7. Fajardo M, Di Cesare PE. Disease-modifying therapies for osteoarthritis : current status. Drugs Aging. 2005; 22(2): 141-61[PubMed]
  • 8. Gregory PJ, Sperry M, Wilson AF. Dietary supplements for osteoarthritis. Am Fam Physician. 2008; 77(2): 177-84[PubMed]
  • 9. Haghighi M, Khalvat A, Toliat T, Jallaei S. Comparing the effects of ginger(zingiber officinale) extract and ibuprofen on patients with osteoarthritis. Arch Iran Med. 2005; 8(4): 267-71
  • 10. Leach MJ, Kumar S. The clinical effectiveness of Ginger (Zingiber officinale) in adults with osteoarthritis. Int J Evid Based Healthc. 2008; 6(3): 311-20[DOI][PubMed]
  • 11. Marcus DM, Suarez-Almazor ME. Is there a role for ginger in the treatment of osteoarthritis? Arthritis Rheum. 2001; 44(11): 2461-2[PubMed]
  • 12. Niempoog S, Pawa KK, Amatyakul C. The efficacy of powdered ginger in osteoarthritis of the knee. J Med Assoc Thai. 2012; 95 Suppl 1-64[PubMed]
  • 13. Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage. 2003; 11(11): 783-9[PubMed]
  • 14. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986; 29(8): 1039-49[PubMed]
  • 15. Ebrahimzadeh MA, Pourmorad F, Hafezi S. Antioxidant activities of Iranian corn silk. Turk J Biol. 2008; 32(1): 43-9
  • 16. Ippoushi K, Azuma K, Ito H, Horie H, Higashio H. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci. 2003; 73(26): 3427-37[PubMed]
  • 17. Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids. 2002; 67(6): 475-8[PubMed]
  • 18. Hosseinzadeh H, Ramezani M, Namjo N. Muscle relaxant activity of Elaeagnus angustifolia L. fruit seeds in mice. J Ethnopharmacol. 2003; 84(2-3): 275-8[PubMed]
  • 19. Ramezani M, Hosseinzadeh H, Daneshmand N. Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice. Fitoterapia. 2001; 72(3): 255-62[PubMed]
  • 20. Dembinska-Migas W, Gill S. Flavonoids in leaves of Elaeagnus angustifolia L. Pol J Pharmacol Pharm. 1973; 25(6): 599-606[PubMed]
  • 21. Zitzer SF, Dawson JO. Seasonal changes in nodular nitrogenase activity of Alnus glutinosa and Elaeagnus angustifolia. Tree Physiol. 1989; 5(2): 185-94[PubMed]
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