Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Review of Sodium Valproate Clinical and Biochemical Properties

Zahra Tolou-Ghamari 1 , * and Abbas Ali Palizban 2
Authors Information
1 Isfahan Neurosciences Research Centre, Isfahan University of Medical Sciences, Isfahan, IR Iran
2 Department of Clinical Biochemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: August 31, 2015, 17 (8); e2207
  • Published Online: August 29, 2015
  • Article Type: Review Article
  • Received: April 23, 2014
  • Accepted: June 10, 2014
  • DOI: 10.17795/zjrms-2207

To Cite: Tolou-Ghamari Z, Palizban A A. Review of Sodium Valproate Clinical and Biochemical Properties, Zahedan J Res Med Sci. 2015 ; 17(8):e2207. doi: 10.17795/zjrms-2207.

Copyright © 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Discussion
  • 1. Burton BS. On the propyl derivatives and decomposition products of ethylacetoacetate. Am Chem J. 1882; 3: 385-95
  • 2. Tenney JR, Jain SV. Absence Epilepsy: Older vs Newer AEDs. Curr Treat Options Neurol. 2014; 16(5): 290[DOI][PubMed]
  • 3. Cincarova L, Zdrahal Z, Fajkus J. New perspectives of valproic acid in clinical practice. Expert Opin Investig Drugs. 2013; 22(12): 1535-47[DOI][PubMed]
  • 4. Manoguerra AS, Erdman AR, Woolf AD, Chyka PA, Caravati EM, Scharman EJ, et al. Valproic acid poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2008; 46(7): 661-76[DOI][PubMed]
  • 5. Ghamari ZT, Habibabadi JM, Palizban AA. Evidence-based pharmacotherapy of epilepsy. Arch Neurosci . 2015; 2(2)[DOI]
  • 6. Tolou-Ghamari Z. Antiepileptic drugs (AEDs) polypharmacy could lead to buried pharmacokinetic interactions due to CYP450. Drug Metab Lett. 2012; 6(3): 207-12[PubMed]
  • 7. Tolou-Ghamari Z, Zare M, Habibabadi JM, Najafi MR. Antiepileptic drugs: a consideration of clinical and biochemical outcome in patients with epilepsy. Int J Prev Med. 2013; 4-7[PubMed]
  • 8. Lemperiere T. [Brief history of the development of valproate in bipolar disorders]. Encephale. 2001; 27(4): 365-72[PubMed]
  • 9. Inoue T, Matsumoto R, Ikeda A. [Treatment of epilepsy in patients of adolescence and adulthood]. Nihon Rinsho. 2014; 72(5): 853-8[PubMed]
  • 10. Lin WW, Jiao Z, Wang CL, Wang HY, Ma CL, Huang PF, et al. Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen. Ther Drug Monit. 2015; 37(1): 76-83[PubMed]
  • 11. Karlov VA, Freidkova NV, Rusanova LV. [Complex therapy of idiopathic forms of epilepsy with small doses of valproates and levetiracetam]. Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(6 Pt 2): 37-9[PubMed]
  • 12. Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Guerreiro C, Kalviainen R, et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2013; 54(3): 551-63[DOI][PubMed]
  • 13. Lemmon ME, Kossoff EH. New treatment options for lennox-gastaut syndrome. Curr Treat Options Neurol. 2013; 15(4): 519-28[DOI][PubMed]
  • 14. Caviness JN, Brown P. Myoclonus: current concepts and recent advances. Lancet Neurol. 2004; 3(10): 598-607[DOI][PubMed]
  • 15. Caviness JN. Treatment of myoclonus. Neurotherapeutics. 2014; 11(1): 188-200
  • 16. Vecht CJ, Kerkhof M, Duran-Pena A. Seizure prognosis in brain tumors: new insights and evidence-based management. Oncologist. 2014; 19(7): 751-9[DOI][PubMed]
  • 17. Rheims S, Ryvlin P. Pharmacotherapy for tonic-clonic seizures. Expert Opin Pharmacother. 2014; 15(10): 1417-26[DOI][PubMed]
  • 18. Jayalakshmi S, Vooturi S, Bana AK, Sailaja S, Somayajula S, Mohandas S. Factors associated with lack of response to valproic acid monotherapy in juvenile myoclonic epilepsy. Seizure. 2014; 23(7): 527-32[DOI][PubMed]
  • 19. Seo J, Howell MD, Singh NN, Singh RN. Spinal muscular atrophy: an update on therapeutic progress. Biochim Biophys Acta. 2013; 1832(12): 2180-90[DOI][PubMed]
  • 20. Perucca E, Aldenkamp A, Tallis R, Kramer G. Role of valproate across the ages. Treatment of epilepsy in the elderly. Acta Neurol Scand Suppl. 2006; 184: 28-37[DOI][PubMed]
  • 21. Lin Y, Lin Y, Li X, Lao G, Jiang Z, Ye B, et al. Monotherapy with lithium or valproate or respectively combination therapy with quetiapine have similar effect on cognitive functions in Chinese euthymic patients with bipolar disorder: a cross-sectional survey. J Clin Psychopharmacol. 2013; 33(6): 817-9[DOI][PubMed]
  • 22. Shao L, Young LT, Wang JF. Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells. Biol Psychiatry. 2005; 58(11): 879-84[DOI][PubMed]
  • 23. Pradat PF, Attarian S, Camdessanche JP. Research in amyotrophic lateral sclerosis: What is new in 2009? Curr Neurol Neurosci Rep. 2011; 11(1): 67-77
  • 24. Lauterbach EC. Neuroprotective effects of psychotropic drugs in Huntington's disease. Int J Mol Sci. 2013; 14(11): 22558-603[DOI][PubMed]
  • 25. Yoon H, Kim DH. Unusual drug reaction between valproate sodium and meropenem. Int J Clin Pharm. 2013; 35(3): 316-8[DOI][PubMed]
  • 26. Haslemo T, Olsen K, Lunde H, Molden E. Valproic Acid significantly lowers serum concentrations of olanzapine-an interaction effect comparable with smoking. Ther Drug Monit. 2012; 34(5): 512-7[DOI][PubMed]
  • 27. Gandelman-Marton R, Neufeld M. [Epilepsy in pregnancy]. Harefuah. 2013; 152(8): 473-6[PubMed]
  • 28. Begum S, Sarma SP, Thomas SV. Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy. Epilepsia. 2013; 54(12)-7[DOI][PubMed]
  • 29. Ahir BK, Pratten MK. Developmental cardiotoxicity effects of four commonly used antiepileptic drugs in embryonic chick heart micromass culture and embryonic stem cell culture systems. Toxicol In Vitro. 2014; 28(5): 948-60[DOI][PubMed]
  • 30. Baek JH, Seo YH, Kim GH, Kim MK, Eun BL. Vitamin D levels in children and adolescents with antiepileptic drug treatment. Yonsei Med J. 2014; 55(2): 417-21[DOI][PubMed]
  • 31. Sarangi SC, Tripathi M, Kakkar AK, Gupta YK. Effect of antiepileptic therapy on trace elements status in Indian population in a tertiary care hospital from northern India: a cross sectional study. Epilepsy Res. 2014; 108(5): 917-27[DOI][PubMed]
  • 32. Singh E, Pillai KK, Mehndiratta MM. Characterization of a lamotrigine‐resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. Basic Clin Pharmacol Toxicol. 2014; 115(5): 373-8
  • 33. Fang J, Chen S, Tong N, Chen L, An D, Mu J, et al. Metabolic syndrome among Chinese obese patients with epilepsy on sodium valproate. Seizure. 2012; 21(8): 578-82[DOI][PubMed]
  • 34. Duncan JS, Sander JW, Sisodiya SM, Walker MC. Adult epilepsy. Lancet. 2006; 367(9516): 1087-100[DOI][PubMed]
  • 35. Depondt C, Shorvon SD. Genetic association studies in epilepsy pharmacogenomics: lessons learnt and potential applications. Pharmacogenomics. 2006; 7(5): 731-45[DOI][PubMed]
  • 36. Bonnett LJ, Tudur Smith C, Smith D, Williamson PR, Chadwick D, Marson AG. Time to 12-month remission and treatment failure for generalised and unclassified epilepsy. J Neurol Neurosurg Psychiatry. 2014; 85(6): 603-10[DOI][PubMed]
  • 37. Yi JH, Cho YJ, Kim WJ, Lee MG, Lee JH. Genetic variations of ABCC2 gene associated with adverse drug reactions to valproic acid in korean epileptic patients. Genomics Inform. 2013; 11(4): 254-62[DOI][PubMed]
  • 38. Unterecker S, Burger R, Hohage A, Deckert J, Pfuhlmann B. Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions. J Clin Psychopharmacol. 2013; 33(4): 561-4[DOI][PubMed]
  • 39. Park MK, Lim KS, Kim TE, Han HK, Yi SJ, Shin KH, et al. Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases. Ther Drug Monit. 2012; 34(5): 599-603[DOI][PubMed]
  • 40. Inoue K, Suzuki E, Takahashi T, Yamamoto Y, Yazawa R, Takahashi Y, et al. 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. Epilepsy Res. 2014; 108(6): 1046-51[DOI][PubMed]
  • 41. Motamedi M, Sahraian MA, Moshirzadeh S. A cross sectional study evaluating perceived impact of epilepsy on aspects of life. Zahedan J Res Med Sci. 2012; 14(4): 33-6
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