Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Novel Homozygous Mutation in the MYO15A Gene in Autosomal Recessive Hearing Loss

Farah Talebi 1 , Farideh Ghanbari Mardasi 2 , * and Javad Mohammadi Asl 3
Authors Information
1 Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, IR Iran
2 Shoushtar Faculty of Medical Sciences, Shoushtar, IR Iran
3 Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: October 2016, 18 (10); e4256
  • Published Online: September 28, 2016
  • Article Type: Case Report
  • Received: October 6, 2015
  • Revised: November 11, 2015
  • Accepted: September 24, 2016
  • DOI: 10.17795/zjrms-4256

To Cite: Talebi F, Ghanbari Mardasi F, Mohammadi Asl J. Novel Homozygous Mutation in the MYO15A Gene in Autosomal Recessive Hearing Loss, Zahedan J Res Med Sci. 2016 ; 18(10):e4256. doi: 10.17795/zjrms-4256.

Abstract
Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Results
4. Discussion
Footnotes
References
  • 1. Smith RJ, Bale JJ, White KR. Sensorineural hearing loss in children. Lancet. 2005; 365(9462): 879-90[DOI][PubMed]
  • 2. Morton NE. Genetic epidemiology of hearing impairment. Ann N Y Acad Sci. 1991; 630: 16-31[PubMed]
  • 3. Bayazit YA, Yilmaz M. An overview of hereditary hearing loss. ORL J Otorhinolaryngol Relat Spec. 2006; 68(2): 57-63[DOI][PubMed]
  • 4. Hilgert N, Smith RJ, Van Camp G. Forty-six genes causing nonsyndromic hearing impairment: which ones should be analyzed in DNA diagnostics? Mutat Res. 2009; 681(2-3): 189-96[DOI][PubMed]
  • 5. Anderson DW, Probst FJ, Belyantseva IA, Fridell RA, Beyer L, Martin DM, et al. The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells. Hum Mol Genet. 2000; 9(12): 1729-38[PubMed]
  • 6. Belyantseva IA, Boger ET, Friedman TB. Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle. Proc Natl Acad Sci U S A. 2003; 100(24): 13958-63[DOI][PubMed]
  • 7. Wang A, Liang Y, Fridell RA, Probst FJ, Wilcox ER, Touchman JW, et al. Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3. Science. 1998; 280(5368): 1447-51[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

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