Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

The Protective Effect of Omega-3 Against Thioacetamide Induced Lipid and Renal Dysfunction in Male Rats

Davood Moghadamnia 1 , 2 , * , Mokhtar Mokhtari 3 and Saeed Khatamsaz 3
Authors Information
1 Department of Biology, Fars Science and Research Branch, Islamic Azad University, Fars, IR Iran
2 Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, IR Iran
3 Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: November 2016, 18 (11); e4781
  • Published Online: October 31, 2016
  • Article Type: Research Article
  • Received: November 22, 2015
  • Revised: February 16, 2016
  • Accepted: October 28, 2016
  • DOI: 10.17795/zjrms-4781

To Cite: Moghadamnia D, Mokhtari M, Khatamsaz S. The Protective Effect of Omega-3 Against Thioacetamide Induced Lipid and Renal Dysfunction in Male Rats, Zahedan J Res Med Sci. 2016 ; 18(11):e4781. doi: 10.17795/zjrms-4781.

Abstract
Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Ozbek E. Induction of oxidative stress in kidney. Int J Nephrol. 2012; 2012: 465897[DOI][PubMed]
  • 2. Begum Q, Noori S, Mahboob T. Antioxidant effect of sodium selenite on thioacetamide-induced renal toxicity. Pak J Biochem Mol Biol. 2011; 44(1): 21-6
  • 3. Plourde M, Cunnane SC. Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab. 2007; 32(4): 619-34[DOI][PubMed]
  • 4. Ashtiyani SC, Najafi H, Kabirinia K, Vahedi E, Jamebozorky L. Oral omega-3 fatty acid for reduction of kidney dysfunction induced by reperfusion injury in rats. Iran J Kidney Dis. 2012; 6(4): 275-83[PubMed]
  • 5. Aukema HM, Lu J, Borthwick F, Proctor SD. Dietary fish oil reduces glomerular injury and elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome. Br J Nutr. 2013; 110(1): 11-9[DOI][PubMed]
  • 6. Mezesova L, Jendruchova-Javorkova V, Vlkovicova J, Okruhlicova L, Frimmel K, Navarova J, et al. Supplementation with n-3 polyunsaturated fatty acids to lipopolysaccharide-induced rats improved inflammation and functional properties of renal Na,K-ATPase. Nutr Res. 2013; 33(9): 772-9[DOI][PubMed]
  • 7. Gani OA, Sylte I. Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha. J Mol Graph Model. 2008; 27(2): 217-24[DOI][PubMed]
  • 8. Kadir FA, Othman F, Abdulla MA, Hussan F, Hassandarvish P. Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats. Indian J Pharmacol. 2011; 43(1): 64-8[DOI][PubMed]
  • 9. Stankova P, Kucera O, Lotkova H, Rousar T, Endlicher R, Cervinkova Z. The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro. 2010; 24(8): 2097-103[DOI][PubMed]
  • 10. Chilakapati J, Korrapati MC, Hill RA, Warbritton A, Latendresse JR, Mehendale HM. Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide. Toxicology. 2007; 230(2-3): 105-16[DOI][PubMed]
  • 11. Sirag HM. Biochemical studies on thioacetamide toxicity in male albino rats and the role of tomato juice as an antioxidant. Mansoura J Forensic Med Clin Toxicol. 2007; 15: 90-114
  • 12. Goksu Erol AY, Avci G, Sevimli A, Ulutas E, Ozdemir M. The protective effects of omega 3 fatty acids and sesame oil against cyclosporine A-induced nephrotoxicity. Drug Chem Toxicol. 2013; 36(2): 241-8[DOI][PubMed]
  • 13. Henry RJ. Principles and techniques. 1974;
  • 14. Patton CJ, Crouch SR. Spectrophotometric and kinetics investigation of the Berthelot reaction for the determination of ammonia. Analyt Chem. 1977; 49(3): 464-9[DOI]
  • 15. Trinder PA. Colorimetric estimation of glucose concentration. Ann Clin Biochem. 1969; 6: 2
  • 16. Richmond W. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem. 1973; 19(12): 1350-6[PubMed]
  • 17. Madani H, Talebolhosseini M, Asgary S, Naderi GH. Hepatoprotective activity of Silybum marianum and Cichorium intybus against thioacetamide in rat. Pak J Nutr. 2008; 7(1): 172-6
  • 18. Kadir FA, Kassim NM, Abdulla MA, Yehye WA. Effect of oral administration of ethanolic extract of Vitex negundo on thioacetamide-induced nephrotoxicity in rats. BMC Complement Altern Med. 2013; 13: 294[DOI][PubMed]
  • 19. El-Mesery M, Al-Gayyar M, Salem H, Darweish M, El-Mowafy A. Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides. Cell Div. 2009; 4: 6[DOI][PubMed]
  • 20. Khan MW, Priyamvada S, Khan SA, Khan S, Naqshbandi A, Yusufi AN. Protective effect of omega-3 polyunsaturated fatty acids (PUFAs) on sodium nitroprusside-induced nephrotoxicity and oxidative damage in rat kidney. Hum Exp Toxicol. 2012; 31(10): 1035-49[DOI][PubMed]
  • 21. Fassett RG, Gobe GC, Peake JM, Coombes JS. Omega-3 polyunsaturated fatty acids in the treatment of kidney disease. Am J Kidney Dis. 2010; 56(4): 728-42[DOI][PubMed]
  • 22. Ajami M, Davoodi SH, Habibey R, Namazi N, Soleimani M, Pazoki-Toroudi H. Effect of DHA+EPA on oxidative stress and apoptosis induced by ischemia-reperfusion in rat kidneys. Fundam Clin Pharmacol. 2013; 27(6): 593-602[DOI][PubMed]
  • 23. An WS, Kim HJ, Cho KH, Vaziri ND. Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. Am J Physiol Renal Physiol. 2009; 297(4)-903[DOI][PubMed]
  • 24. Takase O, Hishikawa K, Kamiura N, Nakakuki M, Kawano H, Mizuguchi K, et al. Eicosapentaenoic acid regulates IkappaBalpha and prevents tubulointerstitial injury in kidney. Eur J Pharmacol. 2011; 669(1-3): 128-35[DOI][PubMed]
  • 25. Abdou HM, Hassan MA. Protective role of omega-3 polyunsaturated fatty acid against lead acetate-induced toxicity in liver and kidney of female rats. Biomed Res Int. 2014; 2014: 435857[DOI][PubMed]
  • 26. Peake JM, Gobe GC, Fassett RG, Coombes JS. The effects of dietary fish oil on inflammation, fibrosis and oxidative stress associated with obstructive renal injury in rats. Mol Nutr Food Res. 2011; 55(3): 400-10[DOI][PubMed]
  • 27. Hassan IR, Gronert K. Acute changes in dietary omega-3 and omega-6 polyunsaturated fatty acids have a pronounced impact on survival following ischemic renal injury and formation of renoprotective docosahexaenoic acid-derived protectin D1. J Immunol. 2009; 182(5): 3223-32[DOI][PubMed]
  • 28. Martini C, Pallottini V, De Marinis E, Marino M, Cavallini G, Donati A, et al. Omega-3 as well as caloric restriction prevent the age-related modifications of cholesterol metabolism. Mech Ageing Dev. 2008; 129(12): 722-7[DOI][PubMed]
  • 29. Wergedahl H, Gudbrandsen OA, Rost TH, Berge RK. Combination of fish oil and fish protein hydrolysate reduces the plasma cholesterol level with a concurrent increase in hepatic cholesterol level in high-fat-fed Wistar rats. Nutrition. 2009; 25(1): 98-104[DOI][PubMed]
  • 30. Kim EH, Bae JS, Hahm KB, Cha JY. Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. Biochem Pharmacol. 2012; 84(10): 1359-65[DOI][PubMed]
  • 31. Al-Gayyar MM, Shams ME, Barakat EA. Fish oil improves lipid metabolism and ameliorates inflammation in patients with metabolic syndrome: impact of nonalcoholic fatty liver disease. Pharm Biol. 2012; 50(3): 297-303[DOI][PubMed]
  • 32. Sekhon-Loodu S, Catalli A, Kulka M, Wang Y, Shahidi F, Rupasinghe HP. Apple flavonols and n-3 polyunsaturated fatty acid-rich fish oil lowers blood C-reactive protein in rats with hypercholesterolemia and acute inflammation. Nutr Res. 2014; 34(6): 535-43[DOI][PubMed]
  • 33. Kaushik M, Mozaffarian D, Spiegelman D, Manson JE, Willett WC, Hu FB. Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus. Am J Clin Nutr. 2009; 90(3): 613-20[DOI][PubMed]
  • 34. Gonzalez-Periz A, Horrillo R, Ferre N, Gronert K, Dong B, Moran-Salvador E, et al. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J. 2009; 23(6): 1946-57[DOI][PubMed]
  • 35. Oh DY, Walenta E. Omega-3 Fatty Acids and FFAR4. Front Endocrinol (Lausanne). 2014; 5: 115[DOI][PubMed]
  • 36. Feillet-Coudray C, Aoun M, Fouret G, Bonafos B, Ramos J, Casas F, et al. Effects of long-term administration of saturated and n-3 fatty acid-rich diets on lipid utilisation and oxidative stress in rat liver and muscle tissues. Br J Nutr. 2013; 110(10): 1789-802[DOI][PubMed]
  • 37. Bouchard-Mercier A, Rudkowska I, Lemieux S, Couture P, Perusse L, Vohl MC. SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation. Lipids Health Dis. 2014; 13: 152[DOI][PubMed]
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