Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Evaluation of E492 Microcin Gene Presence in Klebsiella pneumoniae Collected from Patients Registered to Educational Hospitals of Isfahan

Maryam Nasresfahani 1 , * , Ali Mohammad Ahadi 2 , Hoda Ayat 2 and Hashem Nayeri 3
Authors Information
1 Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2 Department of Genetics, Faculty of Science, Shahr-e-Kord University, Shahr-e-Kord, Iran
3 Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: January 2017, 19 (1); e5038
  • Published Online: January 16, 2017
  • Article Type: Research Article
  • Received: December 13, 2015
  • Revised: June 24, 2016
  • Accepted: January 9, 2017
  • DOI: 10.17795/zjrms-5038

To Cite: Nasresfahani M, Ahadi A M, Ayat H, Nayeri H. Evaluation of E492 Microcin Gene Presence in Klebsiella pneumoniae Collected from Patients Registered to Educational Hospitals of Isfahan, Zahedan J Res Med Sci. 2017 ; 19(1):e5038. doi: 10.17795/zjrms-5038.

Copyright © 2017, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Nguyen DT, Lessor LE, Cahill JL, Rasche ES, Kuty Everett GF. Complete Genome Sequence of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Siphophage Sushi. Genome Announc. 2015; 3(5)[DOI][PubMed]
  • 2. Holt KE, Wertheim H, Zadoks RN, Baker S, Whitehouse CA, Dance D, et al. Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc Natl Acad Sci U S A. 2015; 112(27)-81[DOI][PubMed]
  • 3. Shetty K, Paliyath G, Pometto A, Levin RE. Food biotechnology. 2005;
  • 4. de Lorenzo V, Pugsley AP. Microcin E492, a low-molecular-weight peptide antibiotic which causes depolarization of the Escherichia coli cytoplasmic membrane. Antimicrob Agents Chemother. 1985; 27(4): 666-9[PubMed]
  • 5. Gulluce M, Karaday M, Barıs, O. . Bacteriocins: Promising Natural Antimicrobials. science, technology and education. 2013; : 1016-27
  • 6. Lagos R, Tello M, Mercado G, Garcia V, Monasterio O. Antibacterial and antitumorigenic properties of microcin E492, a pore-forming bacteriocin. Curr Pharm Biotechnol. 2009; 10(1): 74-85[PubMed]
  • 7. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013; 30(1): 108-60[DOI][PubMed]
  • 8. Lagos R, Baeza M, Corsini G, Hetz C, Strahsburger E, Castillo JA, et al. Structure, organization and characterization of the gene cluster involved in the production of microcin E492, a channel-forming bacteriocin. Mol Microbiol. 2001; 42(1): 229-43[PubMed]
  • 9. Vassiliadis G, Destoumieux-Garzon D, Peduzzi J. In Prokaryotic Antimicrobial Peptides. 2011; : 309-32
  • 10. Arranz R, Mercado G, Martin-Benito J, Giraldo R, Monasterio O, Lagos R, et al. Structural characterization of microcin E492 amyloid formation: Identification of the precursors. J Struct Biol. 2012; 178(1): 54-60[DOI][PubMed]
  • 11. Marcoleta A, Marin M, Mercado G, Valpuesta JM, Monasterio O, Lagos R. Microcin e492 amyloid formation is retarded by posttranslational modification. J Bacteriol. 2013; 195(17): 3995-4004[DOI][PubMed]
  • 12. Brisse S, Grimont F, Grimont PAD. The genus Klebsiella. Prokaryotes. 2006; 6: 159-96
  • 13. Alves MS, Dias RC, de Castro AC, Riley LW, Moreira BM. Identification of clinical isolates of indole-positive and indole-negative Klebsiella spp. J Clin Microbiol. 2006; 44(10): 3640-6[DOI][PubMed]
  • 14. Singh M, Kakati B, Agarwal RK, Kotwal A. Detection of Klebsiella pneumoniae carbapenemases (KPCs) among ESBL / MBL producing clinical isolates of Klebsiella pneumonia. Inte J current Microbiol. 2015; 4(4): 726-31
  • 15. Golshani Z, Ahadi AM, Sharifzade A. Occurrence of ambler class b metallo-β-lactamase gene in imipenem-resistant pseudomonas aeruginosa strains isolated from clinical clinical specimens s. Zahedan J Res Med Sci. 2014; 16(2): 6-9
  • 16. Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004; 32(5): 1792-7[DOI][PubMed]
  • 17. Baghani A, Youssefi M, Safdari H, Teimourpour R, Meshkat Z. Designing and Construction Pcdna3.1 Vector Encoding Cfp10 Gene of Mycobacterium tuberculosis. Jundishapur J Microbiol. 2015; 8(10): 23560[DOI][PubMed]
  • 18. de Lorenzo V, Martinez JL, Asensio C. Microcin-mediated interactions between Klebsiella pneumoniae and Escherichia coli strains. J Gen Microbiol. 1984; 130(2): 391-400[DOI][PubMed]
  • 19. Hetz C, Bono MR, Barros LF, Lagos R. Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines. Proc Natl Acad Sci U S A. 2002; 99(5): 2696-701[DOI][PubMed]
  • 20. de Lorenzo V. Isolation and characterization of microcin E492 from Klebsiella pneumoniae. Arch Microbiol. 1984; 139(1): 72-5[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments