Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Protective Effects of Omega Supplement on Induced Hepatic Mal-Function by Thioacetamide in Male Rats

Davood Moghadamnia 1 , 2 , * , Mokhtar Mokhtari 3 and Saeed Khatamsaz 3
Authors Information
1 Department of Biology, Fars Science and Research Branch, Islamic Azad University, Fars, Iran
2 Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
3 Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: March 2017, 19 (3); e5796
  • Published Online: March 31, 2017
  • Article Type: Research Article
  • Received: February 25, 2016
  • Revised: October 18, 2016
  • Accepted: March 19, 2017
  • DOI: 10.5812/zjrms.5796

To Cite: Moghadamnia D, Mokhtari M, Khatamsaz S. Protective Effects of Omega Supplement on Induced Hepatic Mal-Function by Thioacetamide in Male Rats, Zahedan J Res Med Sci. 2017 ; 19(3):e5796. doi: 10.5812/zjrms.5796.

Abstract
Copyright © 2017, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Abboud G, Kaplowitz N. Drug-induced liver injury. Drug Saf. 2007; 30(4): 277-94[PubMed]
  • 2. Medina J, Moreno-Otero R. Pathophysiological basis for antioxidant therapy in chronic liver disease. Drugs. 2005; 65(17): 2445-61[DOI][PubMed]
  • 3. Girish C, Pradhan SC. Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin. Fundam Clin Pharmacol. 2008; 22(6): 623-32[DOI][PubMed]
  • 4. Plourde M, Cunnane SC. Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab. 2007; 32(4): 619-34[DOI][PubMed]
  • 5. Wergedahl H, Gudbrandsen OA, Rost TH, Berge RK. Combination of fish oil and fish protein hydrolysate reduces the plasma cholesterol level with a concurrent increase in hepatic cholesterol level in high-fat-fed Wistar rats. Nutrition. 2009; 25(1): 98-104[DOI][PubMed]
  • 6. Kim EH, Bae JS, Hahm KB, Cha JY. Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. Biochem Pharmacol. 2012; 84(10): 1359-65[DOI][PubMed]
  • 7. Haast RA, Kiliaan AJ. Impact of fatty acids on brain circulation, structure and function. Prostaglandins Leukot Essent Fatty Acids. 2015; 92: 3-14[DOI][PubMed]
  • 8. Siegel G, Ermilov E. Omega-3 fatty acids: benefits for cardio-cerebro-vascular diseases. Atherosclerosis. 2012; 225(2): 291-5[DOI][PubMed]
  • 9. Zhu XH, Wu YF, Qiu YD, Jiang CP, Ding YT. Liver-protecting effects of omega-3 fish oil lipid emulsion in liver transplantation. World J Gastroenterol. 2012; 18(42): 6141-7[DOI][PubMed]
  • 10. Shaaban AA, Shaker ME, Zalata KR, El-kashef HA, Ibrahim TM. Modulation of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis by olmesartan and omega-3. Chem Biol Interact. 2014; 207: 81-91[DOI][PubMed]
  • 11. Wu Z, Qin J, Pu L. Omega-3 fatty acid improves the clinical outcome of hepatectomized patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma. J Biomed Res. 2012; 26(6): 395-9[DOI][PubMed]
  • 12. Natarajan SK, Thomas S, Ramamoorthy P, Basivireddy J, Pulimood AB, Ramachandran A, et al. Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models. J Gastroenterol Hepatol. 2006; 21(6): 947-57[DOI][PubMed]
  • 13. Chilakapati J, Shankar K, Korrapati MC, Hill RA, Mehendale HM. Saturation toxicokinetics of thioacetamide: role in initiation of liver injury. Drug Metab Dispos. 2005; 33(12): 1877-85[DOI][PubMed]
  • 14. Sirag HM. Biochemical studies on thioacetamide toxicity in male albino rats and the role of tomato juice as an antioxidant. Mansoura J Forensic Med Clin Toxicol. 2007; 99-114
  • 15. Goksu Erol AY, Bulbul A, Avci G, Ozdemir M, Akkaya O. The protective effects of omega 3 fatty acids and seasame oil on cyclosporine -A induced liver apoptosis. Orig Invest/Ozgum Arastirma. 2011; 8-11
  • 16. Mostafavi-Pour Z, Zal F, Monabati A, Vessal M. Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Hepatol Res. 2008; 38(4): 385-92[DOI][PubMed]
  • 17. Al-Attar AM. Attenuating effect of Ginkgo biloba leaves extract on liver fibrosis induced by thioacetamide in mice. J Biomed Biotechnol. 2012; 2012: 761450[DOI][PubMed]
  • 18. Alkiyumi SS, Abdullah MA, Alrashdi AS, Salama SM, Abdelwahab SI, Hadi AH. Ipomoea aquatica extract shows protective action against thioacetamide-induced hepatotoxicity. Molecules. 2012; 17(5): 6146-55[DOI][PubMed]
  • 19. Stankova P, Kucera O, Lotkova H, Rousar T, Endlicher R, Cervinkova Z. The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro. 2010; 24(8): 2097-103[DOI][PubMed]
  • 20. Chen WY, Lin SY, Pan HC, Liao SL, Chuang YH, Yen YJ, et al. Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats. J Nutr Biochem. 2012; 23(3): 252-64[DOI][PubMed]
  • 21. Sherif IO, Al-Gayyar MM. Cod liver oil in sodium nitrite induced hepatic injury: does it have a potential protective effect? Redox Rep. 2015; 20(1): 11-6[DOI][PubMed]
  • 22. Roy R, Chandrasekhar D, Pujari P. Dietary fish oil as hepatoprotective agent in Mus musculus. Indian J Exp Biol. 2007; 45(4): 367-70[PubMed]
  • 23. Li CC, Yang HT, Hou YC, Chiu YS, Chiu WC. Dietary fish oil reduces systemic inflammation and ameliorates sepsis-induced liver injury by up-regulating the peroxisome proliferator-activated receptor gamma-mediated pathway in septic mice. J Nutr Biochem. 2014; 25(1): 19-25[DOI][PubMed]
  • 24. Jangale NM, Devarshi PP, Dubal AA, Ghule AE, Koppikar SJ, Bodhankar SL, et al. Dietary flaxseed oil and fish oil modulates expression of antioxidant and inflammatory genes with alleviation of protein glycation status and inflammation in liver of streptozotocin-nicotinamide induced diabetic rats. Food Chem. 2013; 141(1): 187-95[DOI][PubMed]
  • 25. Kim K, Jung N, Lee K, Choi J, Kim S, Jun J, et al. Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts. Clin Nutr. 2013; 32(5): 855-62[DOI][PubMed]
  • 26. Popescu LA, Virgolici B, Lixandru D, Miricescu D, Condrut E, Timnea O, et al. Effect of diet and omega-3 fatty acids in NAFLD. Rom J Morphol Embryol. 2013; 54(3 Suppl): 785-90[PubMed]
  • 27. Zhou GD, Zhu H, Phillips TD, Wang J, Wang SZ, Wang F, et al. Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. PLoS One. 2011; 6(10)[DOI][PubMed]
  • 28. Chen F, Liu Y, Zhu H, Hong Y, Wu Z, Hou Y, et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. Innate Immun. 2013; 19(5): 504-15[DOI][PubMed]
  • 29. de Meijer VE, Gura KM, Le HD, Meisel JA, Puder M. Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: the Boston experience. JPEN J Parenter Enteral Nutr. 2009; 33(5): 541-7[DOI][PubMed]
  • 30. Khan MW, Priyamvada S, Khan SA, Khan S, Gangopadhyay A, Yusufi AN. Fish/flaxseed oil protect against nitric oxide-induced hepatotoxicity and cell death in the rat liver. Hum Exp Toxicol. 2016; 35(3): 302-11[DOI][PubMed]
  • 31. Salama MF, Abbas A, Darweish MM, El-Hawwary AA, Al-Gayyar MM. Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats. Pharm Biol. 2013; 51(11): 1435-43[DOI][PubMed]
  • 32. Goulet OJ. Intestinal failure-associated liver disease and the use of fish oil-based lipid emulsions. World Rev Nutr Diet. 2015; 112: 90-114[DOI][PubMed]
  • 33. Hao W, Wong OY, Liu X, Lee P, Chen Y, Wong KK. omega-3 fatty acids suppress inflammatory cytokine production by macrophages and hepatocytes. J Pediatr Surg. 2010; 45(12): 2412-8[DOI][PubMed]
  • 34. Abdel-Dayem MA, Elmarakby AA, Abdel-Aziz AA, Pye C, Said SA, El-Mowafy AM. Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. Drugs R D. 2014; 14(2): 85-94[DOI][PubMed]
  • 35. Badia-Tahull MB, Leiva-Badosa E, Jodar-Masanes R, Ramon-Torrell JM, Llop-Talaveron J. The relationship between the parenteral dose of fish oil supplementation and the variation of liver function tests in hospitalized adult patients. Nutr J. 2015; 14: 65[DOI][PubMed]
  • 36. Metwally NS, Kholeif TE, Ghanem KZ, Farrag AR, Ammar NM, Abdel-Hamid AH. The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats. Eur Rev Med Pharmacol Sci. 2011; 15(12): 1429-44[PubMed]
  • 37. Lee S, Kim S, Le HD, Meisel J, Strijbosch RA, Nose V, et al. Reduction of hepatocellular injury after common bile duct ligation using omega-3 fatty acids. J Pediatr Surg. 2008; 43(11): 2010-5[DOI][PubMed]
  • 38. Messiha BA, Abo-Youssef AM. Protective effects of fish oil, allopurinol, and verapamil on hepatic ischemia-reperfusion injury in rats. J Nat Sci Biol Med. 2015; 6(2): 351-5[DOI][PubMed]
  • 39. Mardones M, Valenzuela R, Romanque P, Covarrubias N, Anghileri F, Fernandez V, et al. Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol. J Nutr Biochem. 2012; 23(9): 1113-20[DOI][PubMed]
  • 40. Qiu YD, Wang S, Yang Y, Yan XP. Omega-3 polyunsaturated fatty acids promote liver regeneration after 90% hepatectomy in rats. World J Gastroenterol. 2012; 18(25): 3288-95[DOI][PubMed]
  • 41. Chiang KC, Persons KS, Istfan NW, Holick MF, Chen TC. Fish oil enhances the antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 on liver cancer cells. Anticancer Res. 2009; 29(9): 3591-6[PubMed]
  • 42. El-Mowafy AM, Abdel-Dayem MA, Abdel-Aziz A, El-Azab MF, Said SA. Eicosapentaenoic acid ablates valproate-induced liver oxidative stress and cellular derangement without altering its clearance rate: dynamic synergy and therapeutic utility. Biochim Biophys Acta. 2011; 1811(7-8): 460-7[DOI][PubMed]
  • 43. Babcock T, Helton WS, Espat NJ. Eicosapentaenoic acid (EPA): an antiinflammatory omega-3 fat with potential clinical applications. Nutrition. 2000; 16(11-12): 1116-8[DOI][PubMed]
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