Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

The Effect of Aerobic Training on Some Bone Formation Markers (Osteocalcin, Alkaline Phosphatase) in Asthma Treated with Inhaled Corticosteroids

Hassan Ghasemalipour 1 and Mojtaba Eizadi 2 , *
Authors Information
1 Department of Physical Education and Sport Sciences, South Tehran Branch, Islamic Azad University, Tehran, IR Iran
2 Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: January 2018, 20 (1); e58477
  • Published Online: January 20, 2018
  • Article Type: Research Article
  • Received: July 22, 2017
  • Revised: October 7, 2017
  • Accepted: January 14, 2018
  • DOI: 10.5812/zjrms.58477

To Cite: Ghasemalipour H, Eizadi M. The Effect of Aerobic Training on Some Bone Formation Markers (Osteocalcin, Alkaline Phosphatase) in Asthma Treated with Inhaled Corticosteroids, Zahedan J Res Med Sci. 2018 ; 20(1):e58477. doi: 10.5812/zjrms.58477.

Copyright © 2018, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Confavreux CB, Levine RL, Karsenty G. A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms. Mol Cell Endocrinol. 2009;310(1-2):21-9. doi: 10.1016/j.mce.2009.04.004. [PubMed: 19376193].
  • 2. Achemlal L, Tellal S, Rkiouak F, Nouijai A, Bezza A, Derouiche el M, et al. Bone metabolism in male patients with type 2 diabetes. Clin Rheumatol. 2005;24(5):493-6. doi: 10.1007/s10067-004-1070-9. [PubMed: 15747054].
  • 3. Seibel MJ. Biochemical markers of bone turnover: part I: biochemistry and variability. Clin Biochem Rev. 2005;26(4):97-122. [PubMed: 16648882].
  • 4. Stein E, Shane E. Secondary osteoporosis. Endocrinol Metab Clin North Am. 2003;32(1):115-34. vii. [PubMed: 12699295].
  • 5. Chinet T, Dumoulin J, Honore I, Braun JM, Couderc LJ, Febvre M, et al. [The place of inhaled corticosteroids in COPD]. Rev Mal Respir. 2016;33(10):877-91. doi: 10.1016/j.rmr.2015.11.009. [PubMed: 26831345].
  • 6. Weatherall M. A meta-analysis of 25 hydroxyvitamin D in older people with fracture of the proximal femur. N Z Med J. 2000;113(1108):137-40. [PubMed: 10872433].
  • 7. Sucunza N, Barahona MJ, Resmini E, Fernandez-Real JM, Ricart W, Farrerons J, et al. A link between bone mineral density and serum adiponectin and visfatin levels in acromegaly. J Clin Endocrinol Metab. 2009;94(10):3889-96. doi: 10.1210/jc.2009-0474. [PubMed: 19723758].
  • 8. Bergmann P, Body JJ, Boonen S, Boutsen Y, Devogelaer JP, Goemaere S, et al. Evidence-based guidelines for the use of biochemical markers of bone turnover in the selection and monitoring of bisphosphonate treatment in osteoporosis: a consensus document of the Belgian Bone Club. Int J Clin Pract. 2009;63(1):19-26. doi: 10.1111/j.1742-1241.2008.01911.x. [PubMed: 19125989].
  • 9. Kim HJ. New understanding of glucocorticoid action in bone cells. BMB Rep. 2010;43(8):524-9. [PubMed: 20797313].
  • 10. Jan JS, Wu WF. Acute effect of glucocorticoid treatment on serum osteocalcin levels in asthmatic children. J Microbiol Immunol Infect. 2000;33(1):25-8. [PubMed: 10806960].
  • 11. Moazemi M, Jamali FS. The effect of 6-months aerobic exercises on bone-specific alkaline phosphatase and parathyroid hormone in obese inactive woman. J Sport Biomotor Sci. 2014;5(2):71-9.
  • 12. Steinbeck K. Obesity and nutrition in adolescents. Adolesc Med State Art Rev. 2009;20(3):900-14. ix. [PubMed: 20653208].
  • 13. Tauchmanova L, Pivonello R, De Martino MC, Rusciano A, De Leo M, Ruosi C, et al. Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism. Eur J Endocrinol. 2007;157(3):359-66. doi: 10.1530/EJE-07-0137. [PubMed: 17766720].
  • 14. Woitge HW, Friedmann B, Suttner S, Farahmand I, Muller M, Schmidt-Gayk H, et al. Changes in bone turnover induced by aerobic and anaerobic exercise in young males. J Bone Miner Res. 1998;13(12):1797-804. doi: 10.1359/jbmr.1998.13.12.1797. [PubMed: 9844096].
  • 15. Levinger I, Jerums G, Stepto NK, Parker L, Serpiello FR, McConell GK, et al. The effect of acute exercise on undercarboxylated osteocalcin and insulin sensitivity in obese men. J Bone Miner Res. 2014;29(12):2571-6. doi: 10.1002/jbmr.2285. [PubMed: 24861730].
  • 16. Fujimura R, Ashizawa N, Watanabe M, Mukai N, Amagai H, Fukubayashi T, et al. Effect of resistance exercise training on bone formation and resorption in young male subjects assessed by biomarkers of bone metabolism. J Bone Miner Res. 1997;12(4):656-62. doi: 10.1359/jbmr.1997.12.4.656. [PubMed: 9101378].
  • 17. Bagheri L, Salami F, Rajabi H, Bagheri N. Effect of aerobic and strength training on serum PTH, calcium, albumin and alkaline phosphatase in postmenopausal women. J Res Sports Med Technol. 2012;3(19):1-12.
  • 18. Akgu LS, Kanbur N, Cinemre SA, Karabulut E, Derman O. The effect of swimming and type of stroke on bone metabolism in competitive adolescent swimmers: a pilot study. Turk J Med Sci. 2015;45(4):827-32. [PubMed: 26422853].
  • 19. Tosun A, Bolukbasi N, Cingi E, Beyazova M, Unlu M. Acute effects of a single session of aerobic exercise with or without weight-lifting on bone turnover in healthy young women. Mod Rheumatol. 2006;16(5):300-4. doi: 10.1007/s10165-006-0503-5. [PubMed: 17039311].
  • 20. Alghadir AH, Aly FA, Gabr SA. Effect of Moderate Aerobic Training on Bone Metabolism Indices among Adult Humans. Pak J Med Sci. 2014;30(4):840-4. [PubMed: 25097528].
  • 21. Sun X, Li F, Ma X, Ma J, Zhao B, Zhang Y, et al. The Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats. Sci Rep. 2015;5:13009. doi: 10.1038/srep13009. [PubMed: 26260240].
  • 22. Hinton PS, Rector RS, Thomas TR. Weight-bearing, aerobic exercise increases markers of bone formation during short-term weight loss in overweight and obese men and women. Metabolism. 2006;55(12):1616-8. doi: 10.1016/j.metabol.2006.07.023. [PubMed: 17142133].
  • 23. Barnes PJ. Inhaled Corticosteroids. Pharmaceuticals (Basel). 2010;3(3):514-40. doi: 10.3390/ph3030514. [PubMed: 27713266].
  • 24. Andreeva-Gateva PA, Stamenova E, Gatev T. The place of inhaled corticosteroids in the treatment of chronic obstructive pulmonary disease: a narrative review. Postgrad Med. 2016;128(5):474-84. doi: 10.1080/00325481.2016.1186487. [PubMed: 27153510].
  • 25. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. N Engl J Med. 2005;353(16):1711-23. doi: 10.1056/NEJMra050541. [PubMed: 16236742].
  • 26. Chee C, Sellahewa L, Pappachan JM. Inhaled corticosteroids and bone health. Open Respir Med J. 2014;8:85-92. doi: 10.2174/1874306401408010085. [PubMed: 25674178].
  • 27. Weinstein RS. Glucocorticoid-induced osteoporosis and osteonecrosis. Endocrinol Metab Clin North Am. 2012;41(3):595-611. doi: 10.1016/j.ecl.2012.04.004. [PubMed: 22877431].
  • 28. Georgiou KR, Hui SK, Xian CJ. Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy. Am J Stem Cells. 2012;1(3):205-24. [PubMed: 23671809].
  • 29. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor alpha increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011;286(52):44326-35. doi: 10.1074/jbc.M111.283481. [PubMed: 22030390].
  • 30. Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, et al. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 2010;11(6):517-31. doi: 10.1016/j.cmet.2010.05.005. [PubMed: 20519123].
  • 31. Uusi-Rasi K, Sievanen H, Pasanen M, Oja P, Vuori I. Association of physical activity and calcium intake with the maintenance of bone mass in premenopausal women. Osteoporos Int. 2002;13(3):211-7. [PubMed: 11991440].
  • 32. Kemmler W, Lauber D, Weineck J, Hensen J, Kalender W, Engelke K. Benefits of 2 years of intense exercise on bone density, physical fitness, and blood lipids in early postmenopausal osteopenic women: results of the Erlangen Fitness Osteoporosis Prevention Study (EFOPS). Arch Intern Med. 2004;164(10):1084-91. doi: 10.1001/archinte.164.10.1084. [PubMed: 15159265].
  • 33. Falcai MJ, Zamarioli A, Okubo R, de Paula FJ, Volpon JB. The osteogenic effects of swimming, jumping, and vibration on the protection of bone quality from disuse bone loss. Scand J Med Sci Sports. 2015;25(3):390-7. doi: 10.1111/sms.12240. [PubMed: 24779886].
  • 34. Benton MJ, White A. Osteoporosis: recommendations for resistance exercise and supplementation with calcium and vitamin D to promote bone health. J Community Health Nurs. 2006;23(4):201-11. doi: 10.1207/s15327655jchn2304_1. [PubMed: 17064230].

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