Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Effect of Running on Inclined Treadmill on the Occurrence of Knee Joint Osteoarthritis in the Male and Female Wistar Rats

Ramona Mosavian Naeini 1 , Mansour Sahebozamani 1 and Mohammad Naser Nazem 2 , *
Authors Information
1 Department of Sport Injuries and Corrective Exercise, Faculty of Physical Education and Sport Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
2 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: April 2018, 20 (4); e62202
  • Published Online: April 29, 2018
  • Article Type: Research Article
  • Received: October 24, 2017
  • Revised: January 4, 2018
  • Accepted: April 28, 2018
  • DOI: 10.5812/zjrms.62202

To Cite: Mosavian Naeini R, Sahebozamani M, Nazem M N. Effect of Running on Inclined Treadmill on the Occurrence of Knee Joint Osteoarthritis in the Male and Female Wistar Rats, Zahedan J Res Med Sci. 2018 ; 20(4):e62202. doi: 10.5812/zjrms.62202.

Copyright © 2018, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Hansen P, English M, Willick SE. Does running cause osteoarthritis in the hip or knee? PM R. 2012;4(5 Suppl):S117-21. doi: 10.1016/j.pmrj.2012.02.011. [PubMed: 22632690].
  • 2. Otterness IG, Eskra JD, Bliven ML, Shay AK, Pelletier JP, Milici AJ. Exercise protects against articular cartilage degeneration in the hamster. Arthritis Rheum. 1998;41(11):2068-76. [PubMed: 9811063].
  • 3. Ni GX, Zhan LQ, Gao MQ, Lei L, Zhou YZ, Pan YX. Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Arthritis Res Ther. 2011;13(6):R192. doi: 10.1186/ar3521. [PubMed: 22114772]. [PubMed Central: PMC3334642].
  • 4. Fallah Mohammadi M, Hajizadeh Moghaddam A, Mirkarimpur H. The effects of a moderate exercise program on knee osteoarthritis in male wistar rats. Iran J Basic Med Sci. 2013;16(5):683-8. [PubMed: 23826489]. [PubMed Central: PMC3700042].
  • 5. Pierce CM, Laprade RF, Wahoff M, O'Brien L, Philippon MJ. Ice hockey goaltender rehabilitation, including on-ice progression, after arthroscopic hip surgery for femoroacetabular impingement. J Orthop Sports Phys Ther. 2013;43(3):129-41. doi: 10.2519/jospt.2013.4430. [PubMed: 23404067].
  • 6. Messier SP, Mihalko S, Loeser RF, Legault C, Jolla J, Pfruender J, et al. Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study. Osteoarthritis Cartilage. 2007;15(11):1256-66. doi: 10.1016/j.joca.2007.04.016. [PubMed: 17561418].
  • 7. Ding C, Cicuttini F, Scott F, Glisson M, Jones G. Sex differences in knee cartilage volume in adults: role of body and bone size, age and physical activity. Rheumatology (Oxford). 2003;42(11):1317-23. doi: 10.1093/rheumatology/keg374. [PubMed: 12810930].
  • 8. Kawasaki T, Kurosawa H, Ikeda H, Kim SG, Osawa A, Takazawa Y, et al. Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18-month trial. J Bone Miner Metab. 2008;26(3):279-87. doi: 10.1007/s00774-007-0813-5. [PubMed: 18470670].
  • 9. Galois L, Etienne S, Grossin L, Watrin-Pinzano A, Cournil-Henrionnet C, Loeuille D, et al. Dose-response relationship for exercise on severity of experimental osteoarthritis in rats: a pilot study. Osteoarthritis Cartilage. 2004;12(10):779-86. doi: 10.1016/j.joca.2004.06.008. [PubMed: 15450527].
  • 10. Lee YJ, Park JA, Yang SH, Kim KY, Kim BK, Lee EY, et al. Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system. Rheumatol Int. 2011;31(12):1571-6. doi: 10.1007/s00296-010-1520-4. [PubMed: 20490805].
  • 11. Gosvig KK, Jacobsen S, Sonne-Holm S, Gebuhr P. The prevalence of cam-type deformity of the hip joint: a survey of 4151 subjects of the Copenhagen Osteoarthritis Study. Acta Radiol. 2008;49(4):436-41. doi: 10.1080/02841850801935567. [PubMed: 18415788].
  • 12. Jones G, Glisson M, Hynes K, Cicuttini F. Sex and site differences in cartilage development: a possible explanation for variations in knee osteoarthritis in later life. Arthritis Rheum. 2000;43(11):2543-9. [PubMed: 11083279].
  • 13. Faber SC, Eckstein F, Lukasz S, Muhlbauer R, Hohe J, Englmeier KH, et al. Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging. Skeletal Radiol. 2001;30(3):144-50. [PubMed: 11357452].
  • 14. Beckett J, Jin W, Schultz M, Chen A, Tolbert D, Moed BR, et al. Excessive running induces cartilage degeneration in knee joints and alters gait of rats. J Orthop Res. 2012;30(10):1604-10. doi: 10.1002/jor.22124. [PubMed: 22508407].
  • 15. Renner AF, Carvalho E, Soares E, Mattiello-Rosa S. The effect of a passive muscle stretching protocol on the articular cartilage. Osteoarthritis Cartilage. 2006;14(2):196-202. doi: 10.1016/j.joca.2005.08.011. [PubMed: 16243547].
  • 16. Nazem MN, Teymouri M, Jahantigh M. The histomorphometric and histopathologic effect of methionine on the epidermis and dermis layers of skin in rat. Comp Clin Pathol. 2016;25(4):699-704. doi: 10.1007/s00580-016-2250-0.
  • 17. Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971;53(3):523-37. [PubMed: 5580011].
  • 18. Pap G, Eberhardt R, Sturmer I, Machner A, Schwarzberg H, Roessner A, et al. Development of osteoarthritis in the knee joints of Wistar rats after strenuous running exercise in a running wheel by intracranial self-stimulation. Pathol Res Pract. 1998;194(1):41-7. doi: 10.1016/S0344-0338(98)80010-1. [PubMed: 9542746].
  • 19. Krenn V, Morawietz L, Haupl T, Neidel J, Petersen I, Konig A. Grading of chronic synovitis--a histopathological grading system for molecular and diagnostic pathology. Pathol Res Pract. 2002;198(5):317-25. doi: 10.1078/0344-0338-5710261. [PubMed: 12092767].
  • 20. Musumeci G, Loreto C, Leonardi R, Castorina S, Giunta S, Carnazza ML, et al. The effects of physical activity on apoptosis and lubricin expression in articular cartilage in rats with glucocorticoid-induced osteoporosis. J Bone Miner Metab. 2013;31(3):274-84. doi: 10.1007/s00774-012-0414-9. [PubMed: 23263781].
  • 21. Arokoski JP, Jurvelin JS, Vaatainen U, Helminen HJ. Normal and pathological adaptations of articular cartilage to joint loading. Scand J Med Sci Sports. 2000;10(4):186-98. [PubMed: 10898262].
  • 22. Ni GX, Lei L, Zhou YZ. Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage. Arthritis Res Ther. 2012;14(6):R256. doi: 10.1186/ar4101. [PubMed: 23176120]. [PubMed Central: PMC3674602].
  • 23. Ni GX, Liu SY, Lei L, Li Z, Zhou YZ, Zhan LQ. Intensity-dependent effect of treadmill running on knee articular cartilage in a rat model. Biomed Res Int. 2013;2013:172392. doi: 10.1155/2013/172392. [PubMed: 24693534]. [PubMed Central: PMC3892754].
  • 24. Cifuentes DJ, Rocha LG, Silva LA, Brito AC, Rueff-Barroso CR, Porto LC, et al. Decrease in oxidative stress and histological changes induced by physical exercise calibrated in rats with osteoarthritis induced by monosodium iodoacetate. Osteoarthritis Cartilage. 2010;18(8):1088-95. doi: 10.1016/j.joca.2010.04.004. [PubMed: 20417294].
  • 25. Klugl M, Shrier I, McBain K, Shultz R, Meeuwisse WH, Garza D, et al. The prevention of sport injury: an analysis of 12,000 published manuscripts. Clin J Sport Med. 2010;20(6):407-12. doi: 10.1097/JSM.0b013e3181f4a99c. [PubMed: 21079434].
  • 26. Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2010;18(1):24-33. doi: 10.1016/j.joca.2009.08.010. [PubMed: 19751691].
  • 27. Roos EM, Dahlberg L. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum. 2005;52(11):3507-14. doi: 10.1002/art.21415. [PubMed: 16258919].
  • 28. Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ. Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol. 2008;22(2):351-84. doi: 10.1016/j.berh.2008.02.001. [PubMed: 18455690].
  • 29. Fallah-Mohammadi M, Daneshmandi H, Hajizadeh-Moghaddam A, Mirkarimpur SH. The Effect of Aerobic Exercise with and without Quercetin Supplementation on Rat’s Knee Osteoarthritis. Zahedan J Res Med Sci. 2014;16(2):58-63.
  • 30. Sun HB. Mechanical loading, cartilage degradation, and arthritis. Ann N Y Acad Sci. 2010;1211:37-50. doi: 10.1111/j.1749-6632.2010.05808.x. [PubMed: 21062294].
  • 31. Aigner T, McKenna L. Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci. 2002;59(1):5-18. [PubMed: 11846033].
  • 32. Eckstein F, Winzheimer M, Hohe J, Englmeier KH, Reiser M. Interindividual variability and correlation among morphological parameters of knee joint cartilage plates: analysis with three-dimensional MR imaging. Osteoarthritis Cartilage. 2001;9(2):101-11. doi: 10.1053/joca.2000.0365. [PubMed: 11237657].
  • 33. Ding CH, Cicuttini F, Scott F, Glisson M, Jones G. A cross-sectional study of the determinants of knee cartilage volume. Osteoarthritis Cartilage. 2002;10(Suppl A). S57.
  • 34. Dalla Palma L, Cova M, Pozzi-Mucelli RS. MRI appearance of the articular cartilage in the knee according to age. J Belge Radiol. 1997;80(1):17-20. [PubMed: 9103709].
  • 35. Hall FM, Wyshak G. Thickness of articular cartilage in the normal knee. J Bone Joint Surg Am. 1980;62(3):408-13. [PubMed: 7364811].
  • 36. Lukasz S, Muhlbauer R, Faber S, Englmeier KH, Reiser M, Eckstein F. [Sex-specific analysis of cartilage volume in the knee joint--a quantitative MRI-based study]. Ann Anat. 1998;180(6):487-93. German. [PubMed: 9862027].
  • 37. Ben-Hur H, Thole HH, Mashiah A, Insler V, Berman V, Shezen E, et al. Estrogen, progesterone and testosterone receptors in human fetal cartilaginous tissue: immunohistochemical studies. Calcif Tissue Int. 1997;60(6):520-6. [PubMed: 9164826].

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