Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

Mahdi Basiri-Moghadam 1 , Arash Hamzei 2 , Ali-Reza Moslem 3 , Saeid Pasban-Noghabi 4 , * , Nematollah Ghorbani 5 and Jafar Ghenaati 6
Authors Information
1 Department of Nursing, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, IR Iran
2 Department of Anesthesiology, Gonabad University of Medical Sciences, Gonabad, IR Iran
3 Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, IR Iran
4 Department of Nursing, Student Research Committee, Center of Talents, Gonabad University of Medical Sciences, Gonabad, IR Iran
5 Department of Urology, Gonabad University of Medical Sciences, Gonabad, IR Iran
6 Department of Basic Sciences, Gonabad University of Medical Sciences, Gonabad, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: March 31, 2016, 18 (3); e6248
  • Published Online: March 26, 2016
  • Article Type: Research Article
  • Received: June 20, 2015
  • Accepted: November 16, 2015
  • DOI: 10.17795/zjrms-6248

To Cite: Basiri-Moghadam M, Hamzei A, Moslem A, Pasban-Noghabi S, Ghorbani N, et al. Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial, Zahedan J Res Med Sci. 2016 ; 18(3):e6248. doi: 10.17795/zjrms-6248.

Abstract
Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Ghardashi F. Factors affecting preoperative anxiety [in Persian]. Koomesh. 2007; 8(3): 123-30
  • 2. Miller RD, Eriksson LI, Fleisher LA. Miller's Anesthesia. 2009; : 651-5
  • 3. Rostaminejadi AB, Karimi Z. A study on oral ketamine premedication effects on anxiety of parentral separation in 2-7 Y/O children for elective surgery [in Persian] . Arak Med Univ J. 2002; 5(3): 36-41
  • 4. Miller RD, Pardo MC. Basic of anesthesia. 2011; : 137-8
  • 5. Berbel P, Moix J, Quintana S. [Music versus diazepam to reduce preoperative anxiety: a randomized controlled clinical trial]. Rev Esp Anestesiol Reanim. 2007; 54(6): 355-8[PubMed]
  • 6. Schultes RE. The kingdom of plants. Medicines from the earth. 1978; : 208
  • 7. Movafegh A, Alizadeh R, Hajimohamadi F, Esfehani F, Nejatfar M. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg. 2008; 106(6): 1728-32[DOI][PubMed]
  • 8. Verma SK, Bordia A. Antioxidant property of Saffron in man. Indian J Med Sci. 1998; 52(5): 205-7[PubMed]
  • 9. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, Amini H, Fallah-Pour H, Jamshidi AH, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res. 2005; 19(2): 148-51[DOI][PubMed]
  • 10. Akhoundzadeh S, Falahpour H, Afkham K, Jamshidi AH, Khalighi Cigaroudi F, Miller LG. A comparative trial of Crocus sativus L.(saffron) and imipramine in mild to moderate depression. Focus Altern Complement Ther. 2005; 10(1): 22-3
  • 11. Noorbala AA, Akhondzadeh S, Tahmacebi-Pour N, Jamshidi AH. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J Ethnopharmacol. 2005; 97(2): 281-4[DOI][PubMed]
  • 12. Kianbakht S, Ghazavi A. Evaluation of immunological and hematological effects of saffron in men. Ethnopharmacologia. 2005; 36: 78-83
  • 13. Agha-Hosseini M, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara AR, et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG. 2008; 115(4): 515-9[DOI][PubMed]
  • 14. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, et al. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial. J Clin Pharm Ther. 2010; 35(5): 581-8[DOI][PubMed]
  • 15. Fathi-Ashtiani A, Dastani M. Psychological test. 2009; : 337-44
  • 16. Herron ME, Shofer FS, Reisner IR. Retrospective evaluation of the effects of diazepam in dogs with anxiety-related behavior problems. J Am Vet Med Assoc. 2008; 233(9): 1420-4[DOI][PubMed]
  • 17. Shabanian G, Rasti-Boroujeni A, Shirmardi M. Comparison of the effect of Citrus aurantium and diazepam on preoperative anxiety [in Persian] . J Shahrekord Univ Med Sci. 2009; 10(4): 13-8
  • 18. Schull PD. Nursing spectrum drug handbook. 2009; : 339-40
  • 19. Naebi-Nyia AS, Salary S, Modarres-Gharavi M. Studying the relationship between adult attachment style to parents with stress, anxiety and depression. Q J Fundamentals Ment Health. 2011; 13(2): 194-202
  • 20. Axelson DA, Birmaher B. Relation between anxiety and depressive disorders in childhood and adolescence. Depress Anxiety. 2001; 14(2): 67-78[PubMed]
  • 21. Shores MM, Glubin T, Cowley DS, Dager SR, Roy-Byrne PP, Dunner DL. The relationship between anxiety and depression: a clinical comparison of generalized anxiety disorder, dysthymic disorder, panic disorder, and major depressive disorder. Compr Psychiatry. 1992; 33(4): 237-44[PubMed]
  • 22. Shahmansouri N, Farokhnia M, Abbasi SH, Kassaian SE, Noorbala Tafti AA, Gougol A, et al. A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients. J Affect Disord. 2014; 155: 216-22[DOI][PubMed]
  • 23. Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med. 2004; 4: 12[DOI][PubMed]
  • 24. Hosseinzadeh H, Noraei NB. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother Res. 2009; 23(6): 768-74[DOI][PubMed]
  • 25. Pitsikas N, Boultadakis A, Georgiadou G, Tarantilis PA, Sakellaridis N. Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety. Phytomedicine. 2008; 15(12): 1135-9[DOI][PubMed]
  • 26. Abdullaev FI. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp Biol Med (Maywood). 2002; 227(1): 20-5[PubMed]
  • 27. Tarantilis PA, Polissiou MG. Isolation and identification of the aroma components from saffron (Crocus sativus). J Agric Food Chem. 1997; 45(2): 459-62[DOI]
  • 28. Lechtenberg M, Schepmann D, Niehues M, Hellenbrand N, Wunsch B, Hensel A. Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors. Planta Med. 2008; 74(7): 764-72[DOI][PubMed]
  • 29. Kianbakht S. A systematic review on pharmacology of saffron and its active constituents. J Med Plants. 2008; 7(28): 1-27
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments