Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Protective Effect of Carvacrol on Renal Functional and Histopathological Changes in Gentamicin-Induced-Nephrotoxicity in Rats

Hassan Ahmadvand 1 , 2 , * , Majid Tavafi 3 , Vahideh Asadollahi 4 , Leila Jafaripour 5 , Forouzan Hadipour-Moradi 1 , Reza Mohammadrezaei-Khoramabadi 6 , Peyman Khosravi 6 , Hadis Salehi 6 and Ahmad Cheraghi 1
Authors Information
1 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, IR Iran
2 Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, IR Iran
3 Department of Anatomy, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, IR Iran
4 Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, IR Iran
5 Department of Anatomy, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, IR Iran
6 Student Research Commititee, Lorestan University of Medical Sciences, Khorramabad, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: April 30, 2016, 18 (4); e6446
  • Published Online: April 26, 2016
  • Article Type: Research Article
  • Received: January 28, 2015
  • Accepted: August 19, 2015
  • DOI: 10.17795/zjrms-6446

To Cite: Ahmadvand H, Tavafi M, Asadollahi V, Jafaripour L, Hadipour-Moradi F, et al. Protective Effect of Carvacrol on Renal Functional and Histopathological Changes in Gentamicin-Induced-Nephrotoxicity in Rats, Zahedan J Res Med Sci. 2016 ; 18(4):e6446. doi: 10.17795/zjrms-6446.

Abstract
Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Tangden T, Enblad P, Ullberg M, Sjolin J. Neurosurgical gram-negative bacillary ventriculitis and meningitis: a retrospective study evaluating the efficacy of intraventricular gentamicin therapy in 31 consecutive cases. Clin Infect Dis. 2011; 52(11): 1310-6[DOI][PubMed]
  • 2. Corona PS, Espinal L, Rodriguez-Pardo D, Pigrau C, Larrosa N, Flores X. Antibiotic susceptibility in gram-positive chronic joint arthroplasty infections: increased aminoglycoside resistance rate in patients with prior aminoglycoside-impregnated cement spacer use. J Arthroplasty. 2014; 29(8): 1617-21[DOI][PubMed]
  • 3. Shrestha B, Haylor J. Experimental rat models of chronic allograft nephropathy: a review. Int J Nephrol Renovasc Dis. 2014; 7: 315-22[DOI][PubMed]
  • 4. Tavafi M. Protection of renal tubules against gentamicin induced nephrotoxicity. J Renal Inj Prev. 2013; 2(1): 5-6[DOI][PubMed]
  • 5. Tavafi M, Ahmadvand H, Toolabi P. Inhibitory effect of olive leaf extract on gentamicin-induced nephrotoxicity in rats. Iran J Kidney Dis. 2012; 6(1): 25-32[PubMed]
  • 6. Ahmadvand H, Ghasemi Dehnoo M, Dehghani A, Bagheri S, Cheraghi RA. Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10. Ren Fail. 2014; 36(3): 413-8[DOI][PubMed]
  • 7. Stojiljkovic N, Stoiljkovic M, Randjelovic P, Veljkovic S, Mihailovic D. Cytoprotective effect of vitamin C against gentamicin-induced acute kidney injury in rats. Exp Toxicol Pathol. 2012; 64(1-2): 69-74[DOI][PubMed]
  • 8. Moreira MA, Nascimento MA, Bozzo TA, Cintra A, da Silva SM, Dalboni MA, et al. Ascorbic acid reduces gentamicin-induced nephrotoxicity in rats through the control of reactive oxygen species. Clin Nutr. 2014; 33(2): 296-301[DOI][PubMed]
  • 9. Salem EA, Salem NA, Kamel M, Maarouf AM, Bissada NK, Hellstrom WJ, et al. Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure. Ren Fail. 2010; 32(10): 1210-5[DOI][PubMed]
  • 10. Aygun FO, Akcam FZ, Kaya O, Ceyhan BM, Sutcu R. Caffeic acid phenethyl ester modulates gentamicin-induced oxidative nephrotoxicity in kidney of rats. Biol Trace Elem Res. 2012; 145(2): 211-6[DOI][PubMed]
  • 11. Ojano-Dirain CP, Antonelli PJ, Le Prell CG. Mitochondria-targeted antioxidant MitoQ reduces gentamicin-induced ototoxicity. Otol Neurotol. 2014; 35(3): 533-9[DOI][PubMed]
  • 12. Gheissari A, Mehrasa P, Merrikhi A, Madihi Y. Acute kidney injury: A pediatric experience over 10 years at a tertiary care center. J Nephropathol. 2012; 1(2): 101-8[DOI][PubMed]
  • 13. Nasri H. Acute kidney injury and beyond. J Ren Inj Prev. 2012; 1(1): 1-2
  • 14. Romero F, Perez M, Chavez M, Parra G, Durante P. Effect of uric acid on gentamicin-induced nephrotoxicity in rats - role of matrix metalloproteinases 2 and 9. Basic Clin Pharmacol Toxicol. 2009; 105(6): 416-24[DOI][PubMed]
  • 15. Balakumar P, Rohilla A, Thangathirupathi A. Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it? Pharmacol Res. 2010; 62(3): 179-86[DOI][PubMed]
  • 16. Manikandan R, Beulaja M, Thiagarajan R, Priyadarsini A, Saravanan R, Arumugam M. Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats. Eur J Pharmacol. 2011; 670(2-3): 578-85[DOI][PubMed]
  • 17. Tavafi M, Ahmadvand H. Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats. Tissue Cell. 2011; 43(6): 392-7[DOI][PubMed]
  • 18. Nematbakhsh M, Ashrafi F, Safari T, Talebi A, Nasri H, Mortazavi M, et al. Administration of vitamin E and losartan as prophylaxes in cisplatin-induced nephrotoxicity model in rats. J Nephrol. 2012; 25(3): 410-7[DOI][PubMed]
  • 19. Krimer N, Baser KH, Tumen G. Carvacrol rich plants in Turkey. Chem Nat Compounds. 1995; 31(1): 37-42
  • 20. Omidi A, Torabi Z, Hassanpoorfard M, Zardast M. Evaluation of protective effect of hydroalcoholic extract of Crocus sativus petals on preventing of gentamicin induced peliosis hepatis and hepatic telangiectasis in rats: Short communication [in Persian]. J Birjand Univ Med Sci. 2013; 19(4): 455-62
  • 21. Ruberto G, Baratta MT, Deans SG, Dorman HJ. Antioxidant and antimicrobial activity of Foeniculum vulgare and Crithmum maritimum essential oils. Planta Med. 2000; 66(8): 687-93[DOI][PubMed]
  • 22. Alma MH, Mavi A, Yildirim A, Digrak M, Hirata T. Screening chemical composition and in vitro antioxidant and antimicrobial activities of the essential oils from Origanum syriacum L. growing in Turkey. Biol Pharm Bull. 2003; 26(12): 1725-9[PubMed]
  • 23. Im SJ, Kim JH, Kim MY. Evaluation of bioactive components and antioxidant and anticancer properties of citrus wastes generated during bioethanol production. Nat Prod Commun. 2014; 9(4): 483-6[PubMed]
  • 24. Zhou K, Li X, Du Q, Li D, Hu M, Yang X, et al. A CAPE analogue as novel antiplatelet agent efficiently inhibits collagen-induced platelet aggregation. Pharmazie. 2014; 69(8): 615-20[PubMed]
  • 25. Lamarca B. Endothelial dysfunction. An important mediator in the pathophysiology of hypertension during pre-eclampsia. Minerva Ginecol. 2012; 64(4): 309-20[PubMed]
  • 26. Pedraza-Chaverri J, Gonzalez-Orozco AE, Maldonado PD, Barrera D, Medina-Campos ON, Hernandez-Pando R. Diallyl disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats. Eur J Pharmacol. 2003; 473(1): 71-8[PubMed]
  • 27. Safa J, Argani H, Bastani B, Nezami N, Rahimi Ardebili B, Ghorbanihaghjo A, et al. Protective effect of grape seed extract on gentamicin-induced acute kidney injury. Iran J Kidney Dis. 2010; 4(4): 285-91[PubMed]
  • 28. Patel Manali B, Deshpande S, Shah G. Evaluation of efficacy of vitamin E and N-acetyl cysteine in gentamicin-induced nephrotoxicity in rats. Ren Fail. 2011; 33(3): 341-7[DOI][PubMed]
  • 29. Ahmadvand H, Tavafi M, Shahsavari G, Khosrobeigi A, Bagheri S, Abdolahpour F. Hypolipidemic and antiatherogenic effects of Satureja khozestanica essential oil in alloxan-induced type 1 diabetic rats. Zahedan J Res Med Sci. 2013; 15(8): 26-9
  • 30. Ahmadvand H, Tavafi M. Amelioration of glomerulosclerosis by Satureja khozestanica essential oil in alloxaninduced diabetic rats. Zahedan J Res Med Sci. 2014; 16(10): 23-6
  • 31. Bagheri S, Ahmadvand H, Khosrowbeygi A, Ghazanfari F, Jafari N, Nazem H, et al. Antioxidant properties and inhibitory effects of Satureja khozestanica essential oil on LDL oxidation induced-CuSO(4) in vitro. Asian Pac J Trop Biomed. 2013; 3(1): 22-7[DOI][PubMed]
  • 32. Ahmadvand H, Tavafi M, Khalatbary AR. Hepatoprotective and Hypolipidemic Effects of Satureja Khuzestanica Essential Oil in Alloxan-induced Type 1 Diabetic Rats. Iran J Pharm Res. 2012; 11(4): 1219-26[PubMed]
  • 33. Abdel-Raheem IT, Abdel-Ghany AA, Mohamed GA. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol Pharm Bull. 2009; 32(1): 61-7[PubMed]
  • 34. Zietse R, Zoutendijk R, Hoorn EJ. Fluid, electrolyte and acid-base disorders associated with antibiotic therapy. Nat Rev Nephrol. 2009; 5(4): 193-202[DOI][PubMed]
  • 35. Gong X, Celsi G, Carlsson K, Norgren S. Protective effects of N-acetylcysteine amide (NACA) on gentamicin-induced apoptosis in LLC-PK1 cells. Ren Fail. 2012; 34(4): 487-94[DOI][PubMed]
  • 36. Sahu BD, Tatireddy S, Koneru M, Borkar RM, Kumar JM, Kuncha M, et al. Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection. Toxicol Appl Pharmacol. 2014; 277(1): 8-20[DOI][PubMed]
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