Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Sophora pachycarpa Root Extract Improves Testicular Damage in Carbon-Tetrachloride Intoxicated Rats

Seyed Mahdi Banan Khojasteh 1 and Reihaneh Javanmard Khameneh 2 , *
Authors Information
1 Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2 Department of Biology, Faculty of Sciences, University of Urmia, Urmia, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: August 2018, 20 (8); e64950
  • Published Online: October 29, 2018
  • Article Type: Research Article
  • Received: December 9, 2017
  • Revised: February 13, 2018
  • Accepted: July 2, 2018
  • DOI: 10.5812/zjrms.64950

To Cite: Banan Khojasteh S M, Javanmard Khameneh R. Sophora pachycarpa Root Extract Improves Testicular Damage in Carbon-Tetrachloride Intoxicated Rats, Zahedan J Res Med Sci. 2018 ; 20(8):e64950. doi: 10.5812/zjrms.64950.

Copyright © 2018, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Al-Olayan EM, El-Khadragy MF, Metwally DM, Abdel Moneim AE. Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats. BMC Complement Altern Med. 2014;14:164. doi: 10.1186/1472-6882-14-164. [PubMed: 24884677]. [PubMed Central: PMC4041339].
  • 2. Khan RA. Protective effect of Launaea procumbens (L.) on lungs against CCl4-induced pulmonary damages in rat. BMC Complement Altern Med. 2012;12:133. doi: 10.1186/1472-6882-12-133. [PubMed: 22909101]. [PubMed Central: PMC3522065].
  • 3. Noohizadeh N, Parivar K, Hayati Rudbari Z. [The effects of malva sylvestris leaves on sperm and spermatogenesis of the C-57 mice]. J Anim Biol. 2015;7(2):81-8. Persian.
  • 4. Karagiannis A, Harsoulis F. Gonadal dysfunction in systemic diseases. Eur J Endocrinol. 2005;152(4):501-13. doi: 10.1530/eje.1.01886. [PubMed: 15817904].
  • 5. Horn MM, Ramos AR, Winkelmann L, Matte US, Goldani HA, Silveira TR. Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis. Int Braz J Urol. 2006;32(1):94-9. discussion 99. [PubMed: 16519836].
  • 6. Cheng CY, Mruk DD. An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective. Crit Rev Biochem Mol Biol. 2009;44(5):245-63. doi: 10.1080/10409230903061207. [PubMed: 19622063]. [PubMed Central: PMC2758293].
  • 7. Kaur G, Thompson LA, Dufour JM. Sertoli cells--immunological sentinels of spermatogenesis. Semin Cell Dev Biol. 2014;30:36-44. doi: 10.1016/j.semcdb.2014.02.011. [PubMed: 24603046]. [PubMed Central: PMC4043859].
  • 8. Roy A, Sitalakshmi T, Geetha RV, Lakshmi T, Priya VV. In vitro antioxidant and free radical scavenging activity of the ethanolicextract of dioscoreavillosa (wild yam) tubers. Drug Invent. 2011;3(9):214-5.
  • 9. Auddy B, Ferreira M, Blasina F, Lafon L, Arredondo F, Dajas F, et al. Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases. J Ethnopharmacol. 2003;84(2-3):131-8. [PubMed: 12648805].
  • 10. Rechinger KH, Ali SI, Browicz K, Chrtkova-Zertova P, Heller D, Heyn CC, et al. Flora Iranica No. 157. Papilionaceae. Akademischev Druk-u. 1984.
  • 11. Zaurow DE, Strawe L. Medicinal plants of central Asia: Uzbekistan and Kyrgyzstan. 2013. 260 p.
  • 12. Emami SA, Amin-Ar-Ramimeh E, Ahi A, Bolourian Kashy MR, Schneider B, Iranshahi M. Prenylated flavonoids and flavonostilbenes from Sophora pachycarpa roots. Pharm Biol. 2008;45(6):453-7. doi: 10.1080/13880200701389078.
  • 13. Jiang H, Hou C, Zhang S, Xie H, Zhou W, Jin Q, et al. Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur J Pharmacol. 2007;559(2-3):98-108. doi: 10.1016/j.ejphar.2006.12.017. [PubMed: 17291488].
  • 14. Liu SX, Chiou GC. Effects of Chinese herbal products on mammalian retinal functions. J Ocul Pharmacol Ther. 1996;12(3):377-86. doi: 10.1089/jop.1996.12.377. [PubMed: 8875344].
  • 15. Zhang JP, Zhang M, Jin C, Zhou B, Xie WF, Guo C, et al. Matrine inhibits production and actions of fibrogenic cytokines released by mouse peritoneal macrophages. Acta Pharmacol Sin. 2001;22(8):765-8. [PubMed: 11749854].
  • 16. Liu J, Zhu M, Shi R, Yang M. Radix Sophorae flavescentis for chronic hepatitis B: A systematic review of randomized trials. Am J Chin Med. 2003;31(3):337-54. doi: 10.1142/S0192415X03001107. [PubMed: 12943166].
  • 17. Fakhimi A, Iranshahi M, Emami SA, Amin-Ar-Ramimeh E, Zarrini G, Shahverdi AR. Sophoraflavanone G from sophora pachycarpa enhanced the antibacterial activity of gentamycin against Staphylococcus aureus. Z Naturforsch C. 2006;61(9-10):769-72. [PubMed: 17137127].
  • 18. Zhang MJ, Huang J. [Recent research progress of anti-tumor mechnism matrine]. Zhongguo Zhong Yao Za Zhi. 2004;29(2):115-8. Chinese. [PubMed: 15719674].
  • 19. Ma L, Wen S, Zhan Y, He Y, Liu X, Jiang J. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med. 2008;74(3):245-51. doi: 10.1055/s-2008-1034304. [PubMed: 18283616].
  • 20. Eshaghi M, Banihabib N, Zare S, Farokhi F. Reproductive toxic effect of carbon tetrachloride and therapeutic effect of Cornus mas fruit extract on morphology and histology of testis in rats. Int J Fertil Steril. 2012;1(6):87.
  • 21. Chiu YJ, Chou SC, Chiu CS, Kao CP, Wu KC, Chen CJ, et al. Hepatoprotective effect of the ethanol extract of Polygonum orientale on carbon tetrachloride-induced acute liver injury in mice. J Food Drug Anal. 2018;26(1):369-79. doi: 10.1016/j.jfda.2017.04.007. [PubMed: 29389576].
  • 22. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2008;22(3):659-61. doi: 10.1096/fj.07-9574LSF. [PubMed: 17942826].
  • 23. Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risk of male infertility. Hum Reprod. 2001;16(8):1768-76. [PubMed: 11473980].
  • 24. Mohammadi F, Nikzad H, Taherian AA, Amini Mahabadi J, Salehi M. Effects of herbal medicine on male infertility. Anat Sci. 2013;13(4):3-16.
  • 25. Zaman S. [Culture methods, harvest and plant 256 color graphic description]. Tehran: Ghoghnus; 2013. 367 p. Persian.
  • 26. Agarwal A, Desai NR, Ruffoli R, Carpi A. Lifestyle and testicular dysfunction: A brief update. Biomed Pharmacother. 2008;62(8):550-3. doi: 10.1016/j.biopha.2008.07.052. [PubMed: 18771892].
  • 27. Amaral S, Moreno AJ, Santos MS, Seica R, Ramalho-Santos J. Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes. Theriogenology. 2006;66(9):2056-67. doi: 10.1016/j.theriogenology.2006.06.006. [PubMed: 16860381].
  • 28. Aitken RJ, Fisher HM, Fulton N, Gomez E, Knox W, Lewis B, et al. Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine. Mol Reprod Dev. 1997;47(4):468-82. doi: 10.1002/(SICI)1098-2795(199708)47:4<468::AID-MRD14>3.0.CO;2-S. [PubMed: 9211432].
  • 29. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview. Sci World J. 2013;2013:162750. doi: 10.1155/2013/162750. [PubMed: 24470791]. [PubMed Central: PMC3891543].
  • 30. Yaldagard E, Dehghan GH, Hosseinpour Feizi MA, Banan Khojasteh SM. [Protective effects of Sophora pachycarpa root extract against CCl4-induced hepatotoxicity in male rats]. The First National Conference on New Achievements in Biosciences and Agriculture. 2015. Persian.
  • 31. Seyedi Dolatabad S, Khaki A. Effect of Cannabis sativa L. Extract in male genetal system function. BALTICA. 2014;27(1):316-25.
  • 32. Hefnawy HTM, Ramadan MF. Protective effects of Lactuca sativa ethanolic extract on carbon tetrachloride induced oxidative damage in rats. Asia Pac J Trop Dis. 2013;3(4):277-85. doi: 10.1016/s2222-1808(13)60070-5. [PubMed Central: PMC4027310].
  • 33. Shah NA, Khan MR. Increase of glutathione, testosterone and antioxidant effects of Jurenia dolomiaea on CCl4 induced testicular toxicity in rat. BMC Complement Altern Med. 2017;17(1):206. doi: 10.1186/s12906-017-1718-z. [PubMed: 28390404]. [PubMed Central: PMC5385013].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments