Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Investigating the Effect of Experimental Hypothyroidism on Insulin/Thyroid Hormones and Hepatic Steatosis

Vahideh Sadat Nazemi 1 , Mohammad Reza Dayer 1 , * and Tayebeh Mohammadi 1 , 2
Authors Information
1 Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: 21 (1); e65536
  • Published Online: February 6, 2019
  • Article Type: Research Article
  • Received: December 25, 2017
  • Revised: January 13, 2019
  • Accepted: January 26, 2019
  • DOI: 10.5812/zjrms.65536

To Cite: Nazemi V S, Dayer M R, Mohammadi T. Investigating the Effect of Experimental Hypothyroidism on Insulin/Thyroid Hormones and Hepatic Steatosis, Zahedan J Res Med Sci. Online ahead of Print ; 21(1):e65536. doi: 10.5812/zjrms.65536.

Copyright © 2019, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Saleh AAS. Lipid profile and levels of homocysteine and total antioxidant capacity in plasma of rats with experimental thyroid disorders. J Basic Appl Zool. 2015;72:173-8. doi: 10.1016/j.jobaz.2015.01.001.
  • 2. Brenta G. Why can insulin resistance be a natural consequence of thyroid dysfunction? J Thyroid Res. 2011;2011:152850. doi: 10.4061/2011/152850. [PubMed: 21941681]. [PubMed Central: PMC3175696].
  • 3. Enzevaei A, Salehpour S, Tohidi M, Saharkhiz N. Subclinical hypothyroidism and insulin resistance in polycystic ovary syndrome: Is there a relationship? Iran J Reprod Med. 2014;12(7):481-6. [PubMed: 25114670]. [PubMed Central: PMC4126252].
  • 4. Samar AM, Gouda ZA, Ali Khalifa ME, Alkhodary AA. Levothyroxin drug ameliorates the pancreatic changes occurred after induced hypothyroidism in male albino rats. Br J Sci. 2015;12(1):1-17.
  • 5. Farahani H, Ghasemi A, Roghani M, Zahediasl S. Effect of neonatal hypothyroidism on carbohydrate metabolism, insulin secretion, and pancreatic islets morphology of adult male offspring in rats. J Endocrinol Invest. 2013;36(1):44-9. doi: 10.3275/8468. [PubMed: 22732210].
  • 6. Afzal M, Kazmi I, Semwal S, Al-Abbasi FA, Anwar F. Therapeutic exploration of betulinic acid in chemically induced hypothyroidism. Mol Cell Biochem. 2014;386(1-2):27-34. doi: 10.1007/s11010-013-1842-0. [PubMed: 24096699].
  • 7. Zhang Y, Lu P, Zhang L, Xiao X. Association between lipids profile and thyroid parameters in euthyroid diabetic subjects: A cross-sectional study. BMC Endocr Disord. 2015;15:12. doi: 10.1186/s12902-015-0008-3. [PubMed: 25887732]. [PubMed Central: PMC4379692].
  • 8. Silva Nde O, Ronsoni MF, Colombo Bda S, Correa CG, Hatanaka SA, Canalli MH, et al. Clinical and laboratory characteristics of patients with thyroid diseases with and without alanine aminotransferase levels above the upper tertile - Cross-sectional analytical study. Arch Endocrinol Metab. 2016;60(2):101-7. doi: 10.1590/2359-3997000000066. [PubMed: 26331222].
  • 9. Welch-White V, Dawkins N, Graham T, Pace R. The impact of high fat diets on physiological changes in euthyroid and thyroid altered rats. Lipids Health Dis. 2013;12:100. doi: 10.1186/1476-511X-12-100. [PubMed: 23849139]. [PubMed Central: PMC3733864].
  • 10. Alzerjawi JMAASJS. Effect of propylthiouracil-induced hypothyroidism on reproductive effeciency of adult male rats. Bas J Vet Res. 2013;12(2):113-21.
  • 11. Godini A, Ghasemi A, Karbalaei N, Zahediasl S. The effect of thyroidectomy and propylthiouracil-induced hypothyroidism on insulin secretion in male rats. Horm Metab Res. 2014;46(10):710-6. doi: 10.1055/s-0034-1370962. [PubMed: 24627102].
  • 12. Karbalaei N, Ghasemi A, Faraji F, Zahediasl S. Comparison of the effect of maternal hypothyroidism on carbohydrate metabolism in young and aged male offspring in rats. Scand J Clin Lab Invest. 2013;73(1):87-94. doi: 10.3109/00365513.2012.743164. [PubMed: 23198771].
  • 13. Ahmed OM, Gabar MA, Ali TM. Impacts of the coexistence of diabetes and hypothyroidism on body weight gain, leptin and various metabolic aspects in albino rats. J Diabetes Complications. 2012;26(6):491-500. doi: 10.1016/j.jdiacomp.2012.05.021. [PubMed: 22770939].
  • 14. Bancroft JD, Gamble M. Theory and practice of histological techniques. 5th ed. Churchill Livingstone; 2008.
  • 15. Wilcox HG, Keyes WG, Hale TA, Frank R, Morgan DW, Heimberg M. Effects of triiodothyronine and propylthiouracil on plasma lipoproteins in male rats. J Lipid Res. 1982;23(8):1159-66. [PubMed: 6816881].
  • 16. Ashwini S, Bobby Z, Joseph M. Mild hypothyroidism improves glucose tolerance in experimental type 2 diabetes. Chem Biol Interact. 2015;235:47-55. doi: 10.1016/j.cbi.2015.04.007. [PubMed: 25882089].
  • 17. Ali MHM, Saleh HA, Farghaly LM. Role of thyroxin versus Brewer’s yeast supplementation in amelioration of pancreatic alterations induced by hypothyroidism in adult male albino rats. Egypt J Histol. 2013;36(4):918-30.
  • 18. Safayee S, Karbalaei N, Noorafshan A, Nadimi E. Induction of oxidative stress, suppression of glucose-induced insulin release, ATP production, glucokinase activity, and histomorphometric changes in pancreatic islets of hypothyroid rat. Eur J Pharmacol. 2016;791:147-56. doi: 10.1016/j.ejphar.2016.08.024. [PubMed: 27568837].
  • 19. Pacifico L, Bonci E, Ferraro F, Andreoli G, Bascetta S, Chiesa C. Hepatic steatosis and thyroid function tests in overweight and obese children. Int J Endocrinol. 2013;2013:381014. doi: 10.1155/2013/381014. [PubMed: 23431294]. [PubMed Central: PMC3575668].
  • 20. Maratou E, Hadjidakis DJ, Kollias A, Tsegka K, Peppa M, Alevizaki M, et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol. 2009;160(5):785-90. doi: 10.1530/EJE-08-0797. [PubMed: 19141606].
  • 21. Wada M, Yano S, Hamano T, Nabika T, Kumakura S. Effect of serum cholesterol on insulin secretory capacity: Shimane CoHRE study. PLoS One. 2016;11(2). e0149452. doi: 10.1371/journal.pone.0149452. [PubMed: 26881755]. [PubMed Central: PMC4755542].
  • 22. Yadav P, Kaushik GG, Sharma S. Importance of screening type-II diabetics for thyroid dysfunction and dyslipidemia. Int J Biochem Biophys. 2015;3(2):7-12. doi: 10.13189/ijbb.2015.030201.
  • 23. Yang W, Wu DJ, Zhang RH, Deng QH, Ding HY, Tian Y, et al. Effects of propylthiouracil-induced hypothyroidism on nonalcoholic fatty liver disease in rats fed a high-fat and high-cholesterol diet. Pak Vet J. 2015;35(1):1-6.
  • 24. Chen QL, Luo Z, Shi X, Wu K, Zhuo MQ, Song YF, et al. Dietary methimazole-induced hypothyroidism reduces hepatic lipid deposition by down-regulating lipogenesis and up-regulating lipolysis in Pelteobagrus fulvidraco. Gen Comp Endocrinol. 2015;217-218:28-36. doi: 10.1016/j.ygcen.2015.05.006. [PubMed: 25985894].
  • 25. Santana-Farre R, Mirecki-Garrido M, Bocos C, Henriquez-Hernandez LA, Kahlon N, Herrera E, et al. Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood. PLoS One. 2012;7(5). e37386. doi: 10.1371/journal.pone.0037386. [PubMed: 22666351]. [PubMed Central: PMC3354003].
  • 26. Rodriguez-Castelan J, Corona-Perez A, Nicolas-Toledo L, Martinez-Gomez M, Castelan F, Cuevas-Romero E. Hypothyroidism Induces a Moderate Steatohepatitis Accompanied by Liver Regeneration, Mast Cells Infiltration, and Changes in the Expression of the Farnesoid X Receptor. Exp Clin Endocrinol Diabetes. 2017;125(3):183-90. doi: 10.1055/s-0042-112367. [PubMed: 27701715].
  • 27. Messarah M, Boumendjel A, Chouabia A, Klibet F, Abdennour C, Boulakoud MS, et al. Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats. Exp Toxicol Pathol. 2010;62(3):301-10. doi: 10.1016/j.etp.2009.04.009. [PubMed: 19540741].
  • 28. Yao X, Hou S, Zhang D, Xia H, Wang YC, Jiang J, et al. Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. Cell Biosci. 2014;4:38. doi: 10.1186/2045-3701-4-38. [PubMed: 25105012]. [PubMed Central: PMC4124172].

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