Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

Maryam Lotfi-Ghahramanloo 1 and Hasan Baghshani 1 , *
Authors Information
1 Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: May 31, 2016, 18 (5); e6674
  • Published Online: May 16, 2016
  • Article Type: Research Article
  • Received: January 6, 2015
  • Accepted: April 16, 2015
  • DOI: 10.17795/zjrms-6674

To Cite: Lotfi-Ghahramanloo M, Baghshani H. Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice, Zahedan J Res Med Sci. 2016 ; 18(5):e6674. doi: 10.17795/zjrms-6674.

Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Patrick L. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev. 2006; 11(2): 114-27[PubMed]
  • 2. Gurer H, Ercal N. Can antioxidants be beneficial in the treatment of lead poisoning? Free Radic Biol Med. 2000; 29(10): 927-45[PubMed]
  • 3. Ahamed M, Siddiqui MK. Environmental lead toxicity and nutritional factors. Clin Nutr. 2007; 26(4): 400-8[DOI][PubMed]
  • 4. Ajayi GO, Adeniyi TT, Babayemi DO. Hepatoprotective and some haematological effects of Allium sativum and vitamin C in lead-exposed wistar rats. Int J Med Med Sci. 2009; 1(3): 64-7
  • 5. Gurer H, Ozgunes H, Saygin E, Ercal N. Antioxidant effect of taurine against lead-induced oxidative stress. Arch Environ Contam Toxicol. 2001; 41(4): 397-402[DOI][PubMed]
  • 6. Bokara KK, Brown E, McCormick R, Yallapragada PR, Rajanna S, Bettaiya R. Lead-induced increase in antioxidant enzymes and lipid peroxidation products in developing rat brain. Biometals. 2008; 21(1): 9-16[DOI][PubMed]
  • 7. Pari L, Karthikesan K. Protective role of caffeic acid against alcohol-induced biochemical changes in rats. Fundam Clin Pharmacol. 2007; 21(4): 355-61[DOI][PubMed]
  • 8. Pari L, Prasath A. Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats. Chem Biol Interact. 2008; 173(2): 77-83[DOI][PubMed]
  • 9. Arivarasu NA, Priyamvada S, Mahmood R. Caffeic acid inhibits chromium(VI)-induced oxidative stress and changes in brush border membrane enzymes in rat intestine. Biol Trace Elem Res. 2012; 148(2): 209-15[DOI][PubMed]
  • 10. Shahsavani D, Baghshani H, Alishahi E. Efficacy of allicin in decreasing lead (Pb) accumulation in selected tissues of lead-exposed common carp (Cyprinus carpio). Biol Trace Elem Res. 2011; 142(3): 572-80[DOI][PubMed]
  • 11. Najar-Nezhad V, Aslani MR, Balali-Mood M. Evaluation of allicin for the treatment of experimentally induced subacute lead poisoning in sheep. Biol Trace Elem Res. 2008; 126(1-3): 141-7[DOI][PubMed]
  • 12. Latha M, Pari L. Preventive effects of Cassia auriculata L. flowers on brain lipid peroxidation in rats treated with streptozotocin. Mol Cell Biochem. 2003; 243(1-2): 23-8[PubMed]
  • 13. Ellaman GL. Tissue sulfhydryl group. Arch Biochem Biophys. 1959; 82: 70-2
  • 14. Kalia K, Flora SJ. Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. J Occup Health. 2005; 47(1): 1-21[PubMed]
  • 15. Xie L, Gao Q, Xu H. Ameliorative effect of L-methionine on Pb-exposed mice. Biol Trace Elem Res. 2003; 93(1-3): 227-36[DOI][PubMed]
  • 16. Coppock RW, Wagner WC, Reynolds JD, Vogel RS, Gelberg HB, Florence LZ, et al. Evaluation of edetate and thiamine for treatment of experimentally induced environmental lead poisoning in cattle. Am J Vet Res. 1991; 52(11): 1860-5[PubMed]
  • 17. Simon JA, Hudes ES. Relationship of ascorbic acid to blood lead levels. JAMA. 1999; 281(24): 2289-93[PubMed]
  • 18. Gurer H, Ozgunes H, Oztezcan S, Ercal N. Antioxidant role of alpha-lipoic acid in lead toxicity. Free Radic Biol Med. 1999; 27(1-2): 75-81[PubMed]
  • 19. Tandon SK, Flora SJ, Singh S. Influence of pyridoxine (vitamin B6) on lead intoxication in rats. Ind Health. 1987; 25(2): 93-6[PubMed]
  • 20. Xia D, Yu X, Liao S, Shao Q, Mou H, Ma W. Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats. J Ethnopharmacol. 2010; 130(2): 414-20[DOI][PubMed]
  • 21. Shafiq ur R, Rehman S, Chandra O, Abdulla M. Evaluation of malondialdehyde as an index of lead damage in rat brain homogenates. Biometals. 1995; 8(4): 275-9[PubMed]
  • 22. Pande M, Mehta A, Pant BP, Flora SJ. Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats. Environ Toxicol Pharmacol. 2001; 9(4): 173-84[PubMed]
  • 23. Aykin-Burns N, Laegeler A, Kellogg G, Ercal N. Oxidative effects of lead in young and adult Fisher 344 rats. Arch Environ Contam Toxicol. 2003; 44(3): 417-20[DOI][PubMed]
  • 24. Flora SJ, Pande M, Mehta A. Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication. Chem Biol Interact. 2003; 145(3): 267-80[PubMed]
  • 25. Masso-Gonzalez EL, Antonio-Garcia MT. Natural antioxidants protect against lead-induced damage during pregnancy and lactation in rat's pups. Ecotoxicol Environ Saf. 2009; 72(8): 2137-42[DOI][PubMed]
  • 26. Adhami VM, Husain R, Agarwal AK, Seth PK. Intrahippocampal cholinergic-rich transplants restore lead-induced deficits: a preliminary study in rats. Neurotoxicol Teratol. 2000; 22(1): 41-53[PubMed]
  • 27. Konukoglu D, Serin O, Demiriz Kemerli G, Serin E, Hayirhoglu A, Oner B. A study on the carotid artery intima-media thickness and its association with lipid peroxidation. Clin Chim Acta. 1998; 277(1): 91-8[PubMed]
  • 28. Gong Z, Evans HL. Effect of chelation with meso-dimercaptosuccinic acid (DMSA) before and after the appearance of lead-induced neurotoxicity in the rat. Toxicol Appl Pharmacol. 1997; 144(2): 205-14[DOI][PubMed]
  • 29. Sharma V, Sharma A, Kansal L. The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice. Food Chem Toxicol. 2010; 48(3): 928-36[DOI][PubMed]
  • 30. Hsu PC, Liu MY, Hsu CC, Chen LY, Guo YL. Lead exposure causes generation of reactive oxygen species and functional impairment in rat sperm. Toxicology. 1997; 122(1-2): 133-43[PubMed]
  • 31. Shahsavani D, Baghshani H, Aslani MR, Fatemi FS. The impact of allicin on lead-induced oxidative damage in selected organs of the common carp (Cyprinus carpio). Comparat Clin Pathol. 2012; 21(5): 769-75
  • 32. Psotova J, Lasovsky J, Vicar J. Metal-chelating properties, electrochemical behavior, scavenging and cytoprotective activities of six natural phenolics. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003; 147(2): 147-53[PubMed]
  • 33. Babich H, Sedletcaia A, Kenigsberg B. In vitro cytotoxicity of protocatechuic acid to cultured human cells from oral tissue: involvement in oxidative stress. Pharmacol Toxicol. 2002; 91(5): 245-53[PubMed]
  • 34. Nakamura Y, Torikai K, Ohigashi H. Toxic dose of a simple phenolic antioxidant, protocatechuic acid, attenuates the glutathione level in ICR mouse liver and kidney. J Agric Food Chem. 2001; 49(11): 5674-8[PubMed]
  • 35. Yamanaka N, Oda O, Nagao S. Prooxidant activity of caffeic acid, dietary non-flavonoid phenolic acid, on Cu2+-induced low density lipoprotein oxidation. FEBS Lett. 1997; 405(2): 186-90[PubMed]
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