Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Camellia Sinensis Modulates Telomerase in Collagen-Induced Arthritis

Seyedeh Zohreh Jalali 1 and Farshid Saadat 1 , *
Authors Information
1 Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: February 28, 2017, 19 (2); e7210
  • Published Online: March 1, 2017
  • Article Type: Research Article
  • Received: May 21, 2016
  • Revised: August 12, 2016
  • Accepted: February 8, 2017
  • DOI: 10.5812/zjrms.7210

To Cite: Jalali S Z, Saadat F. Camellia Sinensis Modulates Telomerase in Collagen-Induced Arthritis, Zahedan J Res Med Sci. 2017 ; 19(2):e7210. doi: 10.5812/zjrms.7210.

Copyright © 2017, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Gibofsky A. Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Am J Manag Care. 2012; 18(13 Suppl)-302[PubMed]
  • 2. Larsson P, Kleinau S, Holmdahl R, Klareskog L. Homologous type II collagen-induced arthritis in rats. Characterization of the disease and demonstration of clinically distinct forms of arthritis in two strains of rats after immunization with the same collagen preparation. Arthritis Rheum. 1990; 33(5): 693-701[DOI][PubMed]
  • 3. Natarajan V, Madhan B, Tiku ML. Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics. PLoS One. 2015; 10(6)[DOI][PubMed]
  • 4. Yamanishi Y, Hiyama K, Ishioka S, Maeda H, Yamanaka T, Kurose Y, et al. Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases. Int J Mol Med. 1999; 4(5): 513-7[DOI][PubMed]
  • 5. Chen SY, Shiau AL, Shieh GS, Su CH, Lee CH, Lee HL, et al. Amelioration of experimental arthritis by a telomerase-dependent conditionally replicating adenovirus that targets synovial fibroblasts. Arthritis Rheum. 2009; 60(11): 3290-302[DOI][PubMed]
  • 6. Cuzzocrea S, Mazzon E, Di Paola R, Muia C, Crisafulli C, Dugo L, et al. Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse. Clin Immunol. 2006; 120(1): 57-67[DOI][PubMed]
  • 7. Mirshafiey A, Saadat F, Attar M, Di Paola R, Sedaghat R, Cuzzocrea S. Design of a new line in treatment of experimental rheumatoid arthritis by artesunate. Immunopharmacol Immunotoxicol. 2006; 28(3): 397-410[DOI][PubMed]
  • 8. Charles-Schoeman C, Gonzalez-Gay MA, Kaplan I, Boy M, Geier J, Luo Z, et al. Effects of tofacitinib and other DMARDs on lipid profiles in rheumatoid arthritis: implications for the rheumatologist. Semin Arthritis Rheum. 2016; 46(1): 71-80[DOI][PubMed]
  • 9. Scott IC, Ibrahim F, Simpson G, Kowalczyk A, White-Alao B, Hassell A, et al. A randomised trial evaluating anakinra in early active rheumatoid arthritis. Clin Exp Rheumatol. 2016; 34(1): 88-93[PubMed]
  • 10. Genovese MC, van Vollenhoven RF, Pacheco-Tena C, Zhang Y, Kinnman N. VX-509 (Decernotinib), an Oral Selective JAK-3 Inhibitor, in Combination With Methotrexate in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2016; 68(1): 46-55[DOI][PubMed]
  • 11. Lorenz M. Cellular targets for the beneficial actions of tea polyphenols. Am J Clin Nutr. 2013; 98(6 Suppl): 1642S-50S[DOI][PubMed]
  • 12. Lambert JD, Elias RJ. The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys. 2010; 501(1): 65-72[DOI][PubMed]
  • 13. Hong J, Smith TJ, Ho CT, August DA, Yang CS. Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Biochem Pharmacol. 2001; 62(9): 1175-83[DOI][PubMed]
  • 14. Hsu SD, Dickinson DP, Qin H, Borke J, Ogbureke KU, Winger JN, et al. Green tea polyphenols reduce autoimmune symptoms in a murine model for human Sjogren's syndrome and protect human salivary acinar cells from TNF-alpha-induced cytotoxicity. Autoimmunity. 2007; 40(2): 138-47[DOI][PubMed]
  • 15. Xiao J, Ho CT, Liong EC, Nanji AA, Leung TM, Lau TY, et al. Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways. Eur J Nutr. 2014; 53(1): 187-99[DOI][PubMed]
  • 16. Ramadan G, El-Beih NM, Talaat RM, Abd El-Ghffar EA. Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis. Int J Rheum Dis. 2015; [DOI][PubMed]
  • 17. Lee SY, Jung YO, Ryu JG, Oh HJ, Son HJ, Lee SH, et al. Epigallocatechin-3-gallate ameliorates autoimmune arthritis by reciprocal regulation of T helper-17 regulatory T cells and inhibition of osteoclastogenesis by inhibiting STAT3 signaling. J Leukoc Biol. 2016; 100(3): 559-68[DOI][PubMed]
  • 18. Oka Y, Iwai S, Amano H, Irie Y, Yatomi K, Ryu K, et al. Tea polyphenols inhibit rat osteoclast formation and differentiation. J Pharmacol Sci. 2012; 118(1): 55-64[DOI][PubMed]
  • 19. Fearon U, Canavan M, Biniecka M, Veale DJ. Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nat Rev Rheumatol. 2016; 12(7): 385-97[DOI][PubMed]
  • 20. Kyo S, Takakura M, Taira T, Kanaya T, Itoh H, Yutsudo M, et al. Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res. 2000; 28(3): 669-77[DOI][PubMed]
  • 21. Oh S, Song YH, Yim J, Kim TK. Identification of Mad as a repressor of the human telomerase (hTERT) gene. Oncogene. 2000; 19(11): 1485-90[DOI][PubMed]
  • 22. Wang M, Lei YX. Effects of tea polyphenols on proliferation and apoptosis of cadmium-transformed cells. Int J Clin Exp Med. 2015; 8(2): 3054-62[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments