Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Anti-Proliferative and Apoptotic Effects of Beta-Ionone in Human Leukemia Cell Line K562

Zohreh Faezizadeh 1 , * , Amir Gharib 1 and Masoud Godarzee 2
Authors Information
1 Department of Laboratory Sciences, Borujerd Branch, Islamic Azad University, Borujerd, IR Iran
2 Department of Biology, Borujerd Branch, Islamic Azad University, Borujerd, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: June 30, 2016, 18 (6); e7364
  • Published Online: June 13, 2016
  • Article Type: Research Article
  • Received: February 20, 2015
  • Accepted: May 5, 2015
  • DOI: 10.17795/zjrms-7364

To Cite: Faezizadeh Z, Gharib A, Godarzee M. Anti-Proliferative and Apoptotic Effects of Beta-Ionone in Human Leukemia Cell Line K562, Zahedan J Res Med Sci. 2016 ; 18(6):e7364. doi: 10.17795/zjrms-7364.

Abstract
Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Phillipson JD. Phytochemistry and medicinal plants. Phytochemistry. 2001; 56(3): 237-43
  • 2. Gonzales GF, Valerio LJ. Medicinal plants from Peru: a review of plants as potential agents against cancer. Anticancer Agents Med Chem. 2006; 6(5): 429-44[PubMed]
  • 3. Sak K. Chemotherapy and dietary phytochemical agents. Chemotherapy research and practice. 2012; 2012
  • 4. Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer. 2002; 2(4): 277-88[DOI][PubMed]
  • 5. Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr. 2003; 78(3 Suppl): 559S-69S[PubMed]
  • 6. He L, Mo H, Hadisusilo S, Qureshi AA, Elson CE. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr. 1997; 127(5): 668-74[PubMed]
  • 7. Riebeling C, Forsea AM, Raisova M, Orfanos CE, Geilen CC. The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. Br J Cancer. 2002; 87(3): 366-71[DOI][PubMed]
  • 8. Agarwal R, Agarwal C, Ichikawa H, Singh RP, Aggarwal BB. Anticancer potential of silymarin: from bench to bed side. Anticancer Res. 2006; 26(6B): 4457-98[PubMed]
  • 9. Rao AV, Rao LG. Carotenoids and human health. Pharmacol Res. 2007; 55(3): 207-16
  • 10. Lalko J, Lapczynski A, McGinty D, Bhatia S, Letizia CS, Api AM. Fragrance material review on dihydro-beta-ionone. Food Chem Toxicol. 2007; 45 Suppl 1-8[DOI][PubMed]
  • 11. Gomes-Carneiro MR, Dias DM, Paumgartten FJ. Study on the mutagenicity and antimutagenicity of beta-ionone in the Salmonella/microsome assay. Food Chem Toxicol. 2006; 44(4): 522-7[DOI][PubMed]
  • 12. Janakiram NB, Cooma I, Mohammed A, Steele VE, Rao CV. Beta-ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-alpha in human colon cancer cells. Mol Cancer Ther. 2008; 7(1): 181-90[DOI][PubMed]
  • 13. Liu JR, Dong HW, Sun XR, Wang Q, Sun WG, Parry JW, et al. Effects of beta-ionone on mammary carcinogenesis and antioxidant status in rats treated with DMBA. Nutr Cancer. 2010; 62(1): 58-65[DOI][PubMed]
  • 14. Kim MO, Moon DO, Kang CH, Kwon TK, Choi YH, Kim GY. beta-Ionone enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells through Sp1-dependent upregulation of DR5 and downregulation of NF-kappaB activity. Mol Cancer Ther. 2010; 9(4): 833-43[DOI][PubMed]
  • 15. Asokkumar S, Naveenkumar C, Raghunandhakumar S, Kamaraj S, Anandakumar P, Jagan S, et al. Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Mol Cell Biochem. 2012; 363(1-2): 335-45[DOI][PubMed]
  • 16. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2): 55-63[PubMed]
  • 17. Michaud DS, Pietinen P, Taylor PR, Virtanen M, Virtamo J, Albanes D. Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study. Br J Cancer. 2002; 87(9): 960-5[DOI][PubMed]
  • 18. Gharib A, Faezizadeh Z. In vitro anti-telomerase activity of novel lycopene-loaded nanospheres in the human leukemia cell line K562. Pharmacogn Mag. 2014; 10-63[DOI][PubMed]
  • 19. Johnson MD, Woodard A, Okediji EJ, Toms SA, Allen GS. Lovastatin is a potent inhibitor of meningioma cell proliferation: evidence for inhibition of a mitogen associated protein kinase. J Neurooncol. 2002; 56(2): 133-42[PubMed]
  • 20. Moon DO, Kim MO, Lee JD, Choi YH, Kim GY. Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells. Cancer Lett. 2009; 286(2): 172-9[DOI][PubMed]
  • 21. Liu JR, Chen BQ, Yang BF, Dong HW, Sun CH, Wang Q, et al. Apoptosis of human gastric adenocarcinoma cells induced by beta-ionone. World J Gastroenterol. 2004; 10(3): 348-51[PubMed]
  • 22. Zhu J, Zhang L, Jin X, Han X, Sun C, Yan J. beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. Mol Biol Rep. 2010; 37(6): 2653-63[DOI][PubMed]
  • 23. Jones S, Fernandes NV, Yeganehjoo H, Katuru R, Qu H, Yu Z, et al. beta-ionone induces cell cycle arrest and apoptosis in human prostate tumor cells. Nutr Cancer. 2013; 65(4): 600-10[DOI][PubMed]
  • 24. Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC. A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst. 2002; 94(5): 391-8[PubMed]
  • 25. Nahum A, Hirsch K, Danilenko M, Watts CK, Prall OW, Levy J, et al. Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes. Oncogene. 2001; 20(26): 3428-36[DOI][PubMed]
  • 26. Faezizadeh Z, Mesbah-Namin SA, Allameh A. The effect of silymarin on telomerase activity in the human leukemia cell line K562. Planta Med. 2012; 78(9): 899-902[DOI][PubMed]
  • 27. Gopal PK, Paul M, Paul S. Curcumin induces caspase mediated apoptosis in JURKAT cells by disrupting the redox balance. Asian Pac J Cancer Prev. 2014; 15(1): 93-100[PubMed]
  • 28. Wang X, Hao MW, Dong K, Lin F, Ren JH, Zhang HZ. Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression. Arch Pharm Res. 2009; 32(9): 1263-9[DOI][PubMed]
  • 29. Ma J, Han LZ, Liang H, Mi C, Shi H, Lee JJ, et al. Celastrol inhibits the HIF-1alpha pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells. Oncol Rep. 2014; 32(1): 235-42[DOI][PubMed]
  • 30. Lin SC, Li WC, Shih JW, Hong KF, Pan YR, Lin JJ. The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells. Cancer Lett. 2006; 236(1): 80-8[DOI][PubMed]
  • 31. Barzegar E, Fouladdel S, Movahhed TK, Atashpour S, Ghahremani MH, Ostad SN, et al. Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines. Iran J Basic Med Sci. 2015; 18(4): 334-42[PubMed]
  • 32. Moon DO, Kim MO, Choi YH, Lee HG, Kim ND, Kim GY. Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. FEBS Lett. 2008; 582(23-24): 3367-73[DOI][PubMed]
  • 33. Huang ST, Wang CY, Yang RC, Chu CJ, Wu HT, Pang JH. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Phytomedicine. 2010; 17(1): 47-54[DOI][PubMed]
  • 34. Park SE, Park C, Kim SH, Hossain MA, Kim MY, Chung HY, et al. Korean red ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells. J Ethnopharmacol. 2009; 121(2): 304-12[DOI][PubMed]
  • 35. Ranjbari J, Alibakhshi A, Arezumand R, Pourhassan-Moghaddam M, Rahmati M, Zargham N, et al. Effects of curcuma Longa extract on telomerase activity in lung and breast cancer cells. Zahedan J Res Med Sci. 2014; 16(10): 1-6
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