Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Curcumin Effect on the Expressional Profile of OCT4, Nanog and Nucleostemin Genes in AGS (Adenocarcinoma) Cancer Cell Line

Fahmideh Bagrezaei 1 , Mehdi Mahmoodi 2 , Mohammad Reza Hajizadeh 2 , Vajihe Akbarpoor 1 , Reza Bahramabadi 3 and Mohammad Reza Mirzaei 2 , *
Authors Information
1 Faculty of Medicine, Department of Biochemistry, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
2 Faculty of Medicine, Department of Medical Biochemistry, Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
3 Department of Microbiology, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: July 2016, 18 (7); e7555
  • Published Online: July 2, 2016
  • Article Type: Research Article
  • Received: May 14, 2015
  • Accepted: October 29, 2015
  • DOI: 10.17795/zjrms-7555

To Cite: Bagrezaei F, Mahmoodi M, Hajizadeh M R, Akbarpoor V, Bahramabadi R, et al. Curcumin Effect on the Expressional Profile of OCT4, Nanog and Nucleostemin Genes in AGS (Adenocarcinoma) Cancer Cell Line, Zahedan J Res Med Sci. 2016 ; 18(7):e7555. doi: 10.17795/zjrms-7555.

Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Feitelson MA, Arzumanyan A, Kulathinal RJ, Blain SW, Holcombe RF, Mahajna J, et al. Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol. 2015; 35 Suppl-54[DOI][PubMed]
  • 2. Teiten MH, Dicato M, Diederich M. Curcumin as a regulator of epigenetic events. Mol Nutr Food Res. 2013; 57(9): 1619-29[DOI][PubMed]
  • 3. Yallapu MM, Jaggi M, Chauhan SC. Curcumin nanoformulations: a future nanomedicine for cancer. Drug Discov Today. 2012; 17(1-2): 71-80[DOI][PubMed]
  • 4. Singh S, Khar A. Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med Chem. 2006; 6(3): 259-70[PubMed]
  • 5. Cihova M, Altanerova V, Altaner C. Stem cell based cancer gene therapy. Mol Pharm. 2011; 8(5): 1480-7[DOI][PubMed]
  • 6. Charafe-Jauffret E, Ginestier C, Birnbaum D. Breast cancer stem cells: tools and models to rely on. BMC Cancer. 2009; 9: 202[DOI][PubMed]
  • 7. Palm T, Schwamborn JC. Brain tumor stem cells. Biol Chem. 2010; 391(6): 607-17[DOI][PubMed]
  • 8. Shakhova O. Neural crest stem cells in melanoma development. Curr Opin Oncol. 2014; 26(2): 215-21[DOI][PubMed]
  • 9. Oldridge EE, Pellacani D, Collins AT, Maitland NJ. Prostate cancer stem cells: are they androgen-responsive? Mol Cell Endocrinol. 2012; 360(1-2): 14-24[DOI][PubMed]
  • 10. Nicolini A, Ferrari P, Fini M, Borsari V, Fallahi P, Antonelli A, et al. Cancer stem cells: perspectives of new therapeutical approaches for breast cancer. Front Biosci (Schol Ed). 2011; 3: 1486-99[PubMed]
  • 11. Ombrato L, Lluis F, Cosma MP. Regulation of self-renewal and reprogramming by TCF factors. Cell Cycle. 2012; 11(1): 39-47[DOI][PubMed]
  • 12. Wang KH, Kao AP, Chang CC, Lin TC, Kuo TC. Upregulation of Nanog and Sox-2 genes following ectopic expression of Oct-4 in amniotic fluid mesenchymal stem cells. Biotechnol Appl Biochem. 2015; 62(5): 591-7[DOI][PubMed]
  • 13. Afsah Hejri SJ, Mirzaei MR, Arababadi MK, Hassanshahi G, Mahmoodi M. OCT4B1 Down-Regulates Self-Renewal Genes in Cancer Cell Lines. Pharm Sci. 2014; 19(4): 117
  • 14. Cheng X, Meng S, Deng J, Lai W, Wang H. Identification and characterization of the Oct4 extended transcriptional regulatory region in Guanzhong dairy goat. Genome. 2011; 54(10): 812-8[DOI][PubMed]
  • 15. Atlasi Y, Mowla SJ, Ziaee SA, Gokhale PJ, Andrews PW. OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells. Stem Cells. 2008; 26(12): 3068-74[DOI][PubMed]
  • 16. Pan H, Schultz RM. Sox2 modulates reprogramming of gene expression in two-cell mouse embryos. Biol Reprod. 2011; 85(2): 409-16[DOI][PubMed]
  • 17. Wang X, Gingrich DK, Deng Y, Hong Z. A nucleostemin-like GTPase required for normal apical and floral meristem development in Arabidopsis. Mol Biol Cell. 2012; 23(8): 1446-56[DOI][PubMed]
  • 18. Sogi DS, Sharma S, Oberoi DP, Wani IA. Effect of extraction parameters on curcumin yield from turmeric. J Food Sci Technol. 2010; 47(3): 300-4[DOI][PubMed]
  • 19. Kontos CK, Scorilas A, Papavassiliou AG. The role of transcription factors in laboratory medicine. Clin Chem Lab Med. 2013; 51(8): 1563-71[DOI][PubMed]
  • 20. Mirzaei MR, Najafi A, Arababadi MK, Asadi MH, Mowla SJ. Altered expression of apoptotic genes in response to OCT4B1 suppression in human tumor cell lines. Tumour Biol. 2014; 35(10): 9999-10009[DOI][PubMed]
  • 21. Rahman M, Deleyrolle L, Vedam-Mai V, Azari H, Abd-El-Barr M, Reynolds BA. The cancer stem cell hypothesis: failures and pitfalls. Neurosurgery. 2011; 68(2): 531-45[DOI][PubMed]
  • 22. Juhasz K, Lipp AM, Nimmervoll B, Sonnleitner A, Hesse J, Haselgruebler T, et al. The complex function of hsp70 in metastatic cancer. Cancers (Basel). 2013; 6(1): 42-66[DOI][PubMed]
  • 23. Wong TF, Takeda T, Li B, Tsuiji K, Kitamura M, Kondo A, et al. Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition. Gynecol Oncol. 2011; 122(1): 141-8[DOI][PubMed]
  • 24. Mirzaei MR, Hassanshahi G, Mahmoodi M, Hajizadeh MR, Bagrezaei F, Chehardoli M. RNA-Interference-Mediated Silencing of OCT4B1, Alters Expression Profile of Several TNF Ligand/Receptor Transcripts in Human Tumor Cell Lines. Pharm Sci. 2014; 20(3): 114-21
  • 25. Dixon-Shanies D, Shaikh N. Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncol Rep. 1999; 6(6): 1383-7[PubMed]
  • 26. Mudduluru G, George-William JN, Muppala S, Asangani IA, Kumarswamy R, Nelson LD, et al. Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer. Biosci Rep. 2011; 31(3): 185-97[DOI][PubMed]
  • 27. Lim TG, Lee SY, Huang Z, Lim do Y, Chen H, Jung SK, et al. Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. Cancer Prev Res (Phila). 2014; 7(4): 466-74[DOI][PubMed]
  • 28. Li B, Konecke S, Wegiel LA, Taylor LS, Edgar KJ. Both solubility and chemical stability of curcumin are enhanced by solid dispersion in cellulose derivative matrices. Carbohydr Polym. 2013; 98(1): 1108-16[DOI][PubMed]
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