Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Forced Exercise in Combination with 1, 25-dihydroxyvitamin D3 Before Induction of 6-hydroxydopamine Protects Dopaminergic Neurons in Rats Model of Parkinson’s Disease

Fatemeh Mirfakhrai 1 , Ziya Fallah Mohammadi 1 , * and Hossein Fallah Mohammadi 2
Authors Information
1 Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran
2 Department of Cell and Molecular Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: April 2017, 19 (4); e8954
  • Published Online: April 30, 2017
  • Article Type: Research Article
  • Received: September 14, 2016
  • Revised: November 2, 2016
  • Accepted: April 19, 2017
  • DOI: 10.5812/zjrms.8954

To Cite: Mirfakhrai F, Fallah Mohammadi Z, Fallah Mohammadi H. Forced Exercise in Combination with 1, 25-dihydroxyvitamin D3 Before Induction of 6-hydroxydopamine Protects Dopaminergic Neurons in Rats Model of Parkinson’s Disease, Zahedan J Res Med Sci. 2017 ; 19(4):e8954. doi: 10.5812/zjrms.8954.

Abstract
Copyright © 2017, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnotes
References
  • 1. Cheng HC, Ulane CM, Burke RE. Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol. 2010; 67(6): 715-25[DOI][PubMed]
  • 2. Wu SY, Wang TF, Yu L, Jen CJ, Chuang JI, Wu FS, et al. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav Immun. 2011; 25(1): 135-46[DOI][PubMed]
  • 3. Kim H, Heo HI, Kim DH, Ko IG, Lee SS, Kim SE, et al. Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats. Neurosci Lett. 2011; 504(1): 35-9[DOI][PubMed]
  • 4. Choe MA, Koo BS, An GJ, Jeon S. Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned Parkinson's Disease Rat Model. Korean J Physiol Pharmacol. 2012; 16(5): 305-12[DOI][PubMed]
  • 5. Goes AT, Souza LC, Filho CB, Del Fabbro L, De Gomes MG, Boeira SP, et al. Neuroprotective effects of swimming training in a mouse model of Parkinson's disease induced by 6-hydroxydopamine. Neuroscience. 2014; 256: 61-71[DOI][PubMed]
  • 6. Joyce JN, Ryoo HL, Beach TB, Caviness JN, Stacy M, Gurevich EV. Loss of response to levodopa in Parkinson's disease and co-occurrence with dementia: role of D 3 and not D 2 receptors. Brain Res Bull. 2002; 955: 138-52
  • 7. Barbeau A. L-dopa therapy in Parkinson's disease: a critical review of nine years' experience. Can Med Assoc J. 1969; 101: 59-68
  • 8. Huot P, Johnston TH, Koprich JB, Fox SH, Brotchie JM. The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease. Pharmacol Rev. 2013; 65(1): 171-222[DOI][PubMed]
  • 9. Marino MJ, Williams DJ, O'Brien JA, Valenti O, McDonald TP, Clements MK, et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003; 100(23): 13668-73[DOI][PubMed]
  • 10. Farag I, Sherrington C, Hayes A, Canning CG, Lord SR, Close JC, et al. Economic evaluation of a falls prevention exercise program among people With Parkinson's disease. Mov Disord. 2016; 31(1): 53-61[DOI][PubMed]
  • 11. Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Saaksjarvi K, Heliovaara M. Serum vitamin D and the risk of Parkinson disease. Arch Neurol. 2010; 67(7): 808-11[DOI][PubMed]
  • 12. Cui X, Pelekanos M, Liu PY, Burne TH, McGrath JJ, Eyles DW. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience. 2013; 236: 77-87[DOI][PubMed]
  • 13. Evatt ML, Delong MR, Khazai N, Rosen A, Triche S, Tangpricha V. Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol. 2008; 65(10): 1348-52[DOI][PubMed]
  • 14. Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: an evidence-based review. J Am Board Fam Med. 2009; 22(6): 698-706[DOI][PubMed]
  • 15. Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013; 12(10): 976-89[DOI][PubMed]
  • 16. Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int. 2011; 22(3): 859-71[DOI][PubMed]
  • 17. Kalueff AV, Minasyan A, Tuohimaa P. Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice. Brain Res Bull. 2005; 67(1-2): 156-60[DOI][PubMed]
  • 18. Chitsaz Keivan Basiri A, Izadi Boroujeni M, Tanhaei AP, Rahimi M, Rokhsareh Meamar MM. 25-Hydroxyvitamin D and severity of parkinson's disease. Int J Endocrinol. 2013; : 4
  • 19. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998; 78(4): 1193-231[PubMed]
  • 20. da Silva PG, Domingues DD, de Carvalho LA, Allodi S, Correa CL. Neurotrophic factors in Parkinson's disease are regulated by exercise: Evidence-based practice. J Neurol Sci. 2016; 363: 5-15[DOI][PubMed]
  • 21. Goodwin VA, Richards SH, Taylor RS, Taylor AH, Campbell JL. The effectiveness of exercise interventions for people with Parkinson's disease: a systematic review and meta-analysis. Mov Disord. 2008; 23(5): 631-40[DOI][PubMed]
  • 22. Klamroth S, Steib S, Devan S, Pfeifer K. Effects of Exercise Therapy on Postural Instability in Parkinson Disease: A Meta-analysis. J Neurol Phys Ther. 2016; 40(1): 3-14[DOI][PubMed]
  • 23. Smith AD, Zigmond MJ. Can the brain be protected through exercise? Lessons from an animal model of parkinsonism. Exp Neurol. 2003; 184(1): 31-9[PubMed]
  • 24. Yoon MC, Shin MS, Kim TS, Kim BK, Ko IG, Sung YH, et al. Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats. Neurosci Lett. 2007; 423(1): 12-7[DOI][PubMed]
  • 25. Falvo MJ, Schilling BK, Earhart GM. Parkinson's disease and resistive exercise: rationale, review, and recommendations. Mov Disord. 2008; 23(1): 1-11[DOI][PubMed]
  • 26. Zigmond MJ, Smeyne RJ. Exercise: is it a neuroprotective and if so, how does it work? Parkinsonism Relat Disord. 2014; 20 Suppl 1-7[DOI][PubMed]
  • 27. Offen D, Shtaif B, Hadad D, Weizman A, Melamed E, Gil-Ad I. Protective effect of insulin-like-growth-factor-1 against dopamine-induced neurotoxicity in human and rodent neuronal cultures: possible implications for Parkinson's disease. Neurosci Lett. 2001; 316(3): 129-32[PubMed]
  • 28. Doi T, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S. Insulin-like growth factor-1 related to disability among older adults. J Gerontol Ser A Biol Sci Med Sci. 2015;
  • 29. Gillespie CM, Merkel AL, Martin AA. Effects of insulin-like growth factor-I and LR3IGF-I on regional blood flow in normal rats. J Endocrinol. 1997; 155(2): 351-8[PubMed]
  • 30. Li DH, He YC, Quinn TJ, Liu J. Serum Insulin-Like Growth Factor-1 in Patients with De Novo, Drug Naive Parkinson's Disease: A Meta-Analysis. PLoS One. 2015; 10(12): 144755[DOI][PubMed]
  • 31. Ebert AD, Beres AJ, Barber AE, Svendsen CN. Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. Exp Neurol. 2008; 209(1): 213-23[DOI][PubMed]
  • 32. Morisawa K, Sugisaki T, Kanamatsu T, Aoki T, Noguchi T. Factors contributing to cerebral hypomyelination in the growth hormone-deficient little mouse. Neurochem Res. 1989; 14(2): 173-7[PubMed]
  • 33. Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol. 2013; 34(1): 47-64[DOI][PubMed]
  • 34. Smith MP, Fletcher-Turner A, Yurek DM, Cass WA. Calcitriol protection against dopamine loss induced by intracerebroventricular administration of 6-hydroxydopamine. Neurochem Res. 2006; 31(4): 533-9[DOI][PubMed]
  • 35. Carlsson T, Schindler FR, Hollerhage M, Depboylu C, Arias-Carrion O, Schnurrbusch S, et al. Systemic administration of neuregulin-1beta1 protects dopaminergic neurons in a mouse model of Parkinson's disease. J Neurochem. 2011; 117(6): 1066-74[DOI][PubMed]
  • 36. Landers MR, Kinney JW, Van Breukelen F. Forced exercise before or after induction of 6-OHDA-mediated nigrostriatal insult does not mitigate behavioral asymmetry in a hemiparkinsonian rat model. . Brain Res Bull. 2014; 1543: 263-70
  • 37. Mabandla M, Kellaway L, St Clair Gibson A, Russell VA. Voluntary running provides neuroprotection in rats after 6-hydroxydopamine injection into the medial forebrain bundle. Metab Brain Dis. 2004; 19(1-2): 43-50[PubMed]
  • 38. Ayadi A, Zigmond MJ, Smith AD. IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases. Exp Brain Res. 2016;
  • 39. Smolders J, Moen SM, Damoiseaux J, Huitinga I, Holmoy T. Vitamin D in the healthy and inflamed central nervous system: access and function. J Neurol Sci. 2011; 311(1-2): 37-43[DOI][PubMed]
  • 40. Choi M, Park H, Cho S, Lee M. Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high-intensity exercise in SD rats. Cytokine. 2013; 63(1): 27-35[DOI][PubMed]
  • 41. Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004; 79(3): 362-71[PubMed]
  • 42. Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007; 30(9): 464-72[DOI][PubMed]
  • 43. Woods JA, Wilund KR, Martin SA, Kistler BM. Exercise, inflammation and aging. Aging Dis. 2012; 3(1): 130-40[PubMed]
  • 44. Sung YH, Kim SC, Hong HP, Park CY, Shin MS, Kim CJ, et al. Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice. Life Sci. 2012; 91(25-26): 1309-16[DOI][PubMed]
  • 45. Morillas-Ruiz JM, Villegas Garcia JA, Lopez FJ, Vidal-Guevara ML, Zafrilla P. Effects of polyphenolic antioxidants on exercise-induced oxidative stress. Clin Nutr. 2006; 25(3): 444-53[DOI][PubMed]
  • 46. Harms LR, Burne TH, Eyles DW, McGrath JJ. Vitamin D and the brain. Best Pract Res Clin Endocrinol Metab. 2011; 25(4): 657-69[DOI][PubMed]
  • 47. Shinpo K, Kikuchi S, Sasaki H, Moriwaka F, Tashiro K. Effect of 1,25-dihydroxyvitamin D(3) on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine. J Neurosci Res. 2000; 62(3): 374-82[DOI][PubMed]
  • 48. Newmark HL, Newmark J. Vitamin D and Parkinson's disease--a hypothesis. Mov Disord. 2007; 22(4): 461-8[DOI][PubMed]
  • 49. Lev N, Melamed E, Offen D. Apoptosis and Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27(2): 245-50[DOI][PubMed]
  • 50. Mabandla MV, Russell VA. Voluntary exercise reduces the neurotoxic effects of 6-hydroxydopamine in maternally separated rats. Behav Brain Res. 2010; 211(1): 16-22[DOI][PubMed]
  • 51. Speelman AD, van de Warrenburg BP, van Nimwegen M, Petzinger GM, Munneke M, Bloem BR. How might physical activity benefit patients with Parkinson disease? Nat Rev Neurol. 2011; 7(9): 528-34[DOI][PubMed]
  • 52. Scott JP, Sale C, Greeves JP, Casey A, Dutton J, Fraser WD. Treadmill running reduces parathyroid hormone concentrations during recovery compared with a nonexercising control group. J Clin Endocrinol Metab. 2014; 99(5): 1774-82[DOI][PubMed]
  • 53. Tosun A, Bolukbasi N, Cingi E, Beyazova M, Unlu M. Acute effects of a single session of aerobic exercise with or without weight-lifting on bone turnover in healthy young women. Mod Rheumatol. 2006; 16(5): 300-4[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments