Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Cytotoxic Effect of Albendazole on the Breast Cancer and Melanoma Cell Lines

Sepideh Javdan 1 , Hashem Nayeri 1 , * and Golnaz Vaseghi 2
Authors Information
1 Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2 Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: June 2018, 20 (6); e9100
  • Published Online: August 12, 2018
  • Article Type: Research Article
  • Received: September 23, 2016
  • Revised: March 13, 2018
  • Accepted: April 4, 2018
  • DOI: 10.5812/zjrms.9100

To Cite: Javdan S, Nayeri H, Vaseghi G . Cytotoxic Effect of Albendazole on the Breast Cancer and Melanoma Cell Lines, Zahedan J Res Med Sci. 2018 ; 20(6):e9100. doi: 10.5812/zjrms.9100.

Copyright © 2018, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11-30. doi: 10.3322/caac.21166. [PubMed: 23335087].
  • 2. Meacham CE, Morrison SJ. Tumour heterogeneity and cancer cell plasticity. Nature. 2013;501(7467):328-37. doi: 10.1038/nature12624. [PubMed: 24048065]. [PubMed Central: PMC4521623].
  • 3. Fisher R, Pusztai L, Swanton C. Cancer heterogeneity: implications for targeted therapeutics. Br J Cancer. 2013;108(3):479-85. doi: 10.1038/bjc.2012.581. [PubMed: 23299535]. [PubMed Central: PMC3593543].
  • 4. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer. 1999;80(6):827-41.
  • 5. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70. [PubMed: 10647931].
  • 6. Teicher BA, Selwood DL, Andrews PA. Erratum: Anticancer drug development: preclinical screening, clinical trials and approval. British Journal of Cancer. 2004;91(11):1977. doi: 10.1038/sj.bjc.6602286.
  • 7. Gallucci BB. Selected concepts of cancer as a disease: from the Greeks to 1900. Oncol Nurs Forum. 1985;12(4):67-71. [PubMed: 3892501].
  • 8. Pourgholami MH, Yan Cai Z, Lu Y, Wang L, Morris DL. Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice. Clin Cancer Res. 2006;12(6):1928-35. doi: 10.1158/1078-0432.CCR-05-1181. [PubMed: 16551879].
  • 9. Pourgholami MH, Wangoo KT, Morris DL. Albendazole-cyclodextrin complex: enhanced cytotoxicity in ovarian cancer cells. Anticancer Res. 2008;28(5A):2775-9. [PubMed: 19035309].
  • 10. Gupta RS. Cross-resistance of nocodazole-resistant mutants of CHO cells toward other microtubule inhibitors: similar mode of action of benzimidazole carbamate derivatives and NSC 181928 and TN-16. Mol Pharmacol. 1986;30(2):142-8. [PubMed: 3736539].
  • 11. Pourgholami MH, Akhter J, Wang L, Lu Y, Morris DL. Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis. Cancer Chemother Pharmacol. 2005;55(5):425-32. doi: 10.1007/s00280-004-0927-6. [PubMed: 15565325].
  • 12. Patel K, Doudican NA, Schiff PB, Orlow SJ. Albendazole sensitizes cancer cells to ionizing radiation. Radiat Oncol. 2011;6:160. doi: 10.1186/1748-717X-6-160. [PubMed: 22094106]. [PubMed Central: PMC3231941].
  • 13. Pourgholami MH, Woon L, Almajd R, Akhter J, Bowery P, Morris DL. In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by albendazole. Cancer Lett. 2001;165(1):43-9. doi: 10.1016/s0304-3835(01)00382-2.
  • 14. Morris DL, Jourdan JL, Pourgholami MH. Pilot study of albendazole in patients with advanced malignancy. Effect on serum tumor markers/high incidence of neutropenia. Oncology. 2001;61(1):42-6. doi: 10.1159/000055351. [PubMed: 11474247].
  • 15. Alvarez LI, Sanchez SF, Lanusse CE. In vivo and ex vivo uptake of albendazole and its sulphoxide metabolite by cestode parasites: relationship with their kinetic behaviour in sheep. J Vet Pharmacol Ther. 1999;22(2):77-86. [PubMed: 10372592].
  • 16. Kralova V, Hanusova V, Stankova P, Knoppova K, Canova K, Skalova L. Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines. Anticancer Drugs. 2013;24(9):911-9. doi: 10.1097/CAD.0b013e3283648c69. [PubMed: 23884106].
  • 17. Pourgholami MH, Szwajcer M, Chin M, Liauw W, Seef J, Galettis P, et al. Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer. Cancer Chemother Pharmacol. 2010;65(3):597-605. doi: 10.1007/s00280-009-1157-8. [PubMed: 19904538].
  • 18. Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010;70(2):440-6. doi: 10.1158/0008-5472.CAN-09-1947. [PubMed: 20068163].
  • 19. Ehteda A, Galettis P, Pillai K, Morris DL. Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice. BMC Cancer. 2013;13:86. doi: 10.1186/1471-2407-13-86. [PubMed: 23432760]. [PubMed Central: PMC3606618].
  • 20. Chu SW, Badar S, Morris DL, Pourgholami MH. Potent inhibition of tubulin polymerisation and proliferation of paclitaxel-resistant 1A9PTX22 human ovarian cancer cells by albendazole. Anticancer Res. 2009;29(10):3791-6. [PubMed: 19846910].
  • 21. Khalilzadeh A, Wangoo KT, Morris DL, Pourgholami MH. Epothilone-paclitaxel resistant leukemic cells CEM/dEpoB300 are sensitive to albendazole: Involvement of apoptotic pathways. Biochem Pharmacol. 2007;74(3):407-14. doi: 10.1016/j.bcp.2007.05.006. [PubMed: 17560963].
  • 22. Kummalue T. Molecular mechanism of herbs in human lung cancer cells. J Med Assoc Thai. 2005;88(11):1725-34. [PubMed: 16471127].
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