Effect of Urtica Dioica Extract on Histological and Histometrical Changes of Testis of Hamster after Testosteron Administration

AUTHORS

Hassan Morovvati 1 , Hossein Najafzadeh 2 , * , Khodabakhsh Rashidi 3

AUTHORS INFORMATION

1 Department of Veterinary Histology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

2 Department of Veterinary Histology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3 Department of Medical Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

How to Cite: Morovvati H, Najafzadeh H , Rashidi K. Effect of Urtica Dioica Extract on Histological and Histometrical Changes of Testis of Hamster after Testosteron Administration, Zahedan J Res Med Sci. 2013 ; 15(11):e92775.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (11); e92775
Published Online: May 20, 2013
Article Type: Research Article
Received: October 21, 2012
Revised: December 20, 2012
Accepted: February 16, 2013

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Abstract

Background: Hyperactivity of testosterone is one cause of infertility and its incorrect use can produces reproductive disorders. Nettle (Urtica dioica) has antiandrogenic effect and may antagonized effect of testosterone. In present study structure of testes of golden hamster was evaluated after testosterone and extract.
Materials and Methods: In this experimental and animal modeling study, twenty male mature hamsters were divided to 4 groups, group 1 was control, group 2 received testosterone at dose 3 mg/kg subcutaneously, group 3 received nettle extract dose 30 mg/kg orally and group 4 received testosterone and nettle for 30 days daily. The hamsters were euthanized and testes were removed and detected macroscopic parameters (weight, height, wide and volume) and fixed with formalin. The samples were sectioned and colored with H & E.
Results: The volume, weight, length and wide of testes was at least in testosterone group and statistically was lesser than control and testosterone -nettle group (p<0.05), but did not the height epithelium of seminifer tubules, compact of spermatogenic cells and number of serotolli cells in testosterone group was lesser than control group significantly (p<0.05).
Conclusion: The nettle extract decreased histological changes of testes by testosterone and improved its structure.

Keywords

Testes tissue Testosterone Urtica dioica extract Hamster

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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