Effect of Urtica Dioica Decoction on Serum Glucose and Lipid Profile in Stereptozotocin Induced Diabetic Male Rats

AUTHORS

Mohammad Reza Shahraki 1 , * , Hamideh Mirshekari 2 , Ahmad Reza Sahraki 3 , Elnaz Shafighi 4

AUTHORS INFORMATION

1 Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran

2 General Physician, Zahedan Health Service Center, Zahedan University of Medical Sciences, Zahedan, Iran

3 General Physician, Chabahar Health Service Center, Zahedan University of Medical Sciences, Chabahar, Iran

4 Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

How to Cite: Shahraki M R , Mirshekari H, Sahraki A R, Shafighi E. Effect of Urtica Dioica Decoction on Serum Glucose and Lipid Profile in Stereptozotocin Induced Diabetic Male Rats, Zahedan J Res Med Sci. 2013 ; 15(11):e92784.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (11); e92784
Published Online: February 10, 2013
Article Type: Research Article
Received: July 01, 2012
Revised: September 28, 2012
Accepted: November 17, 2012

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Abstract

Background: Since Urtica dioica is a traditional treatment plant and is used for antihypertensive, antilipidemic and antidiabetic agents, this survey was carried out to evaluate the effect of Urtica dioica decoction on serum glucose and lipid profile in diabetic male rats induced by stereptozotocin (STZ).
Materials and Methods: This experiment was performed on 30 Wistar-Albino male rats, weighing 200-250 g, which were divided in sham control (A), diabetic control (B) and diabetic test groups (C) randomly (N=10). Type I diabetes was induced by single intraperitoneal injection of STZ (65 mg/kg). Test group received 0.40-0.60 ml of Urtica dioica decoction for a month by gavages, control group (B) received the same volume of distill water. Group (A) did not receive any agent during the experiment period. Finally, animals were anesthetized, sacrificed and blood samples were collected from the cervical vein. Then, serum glucose and lipid profiles were measured by ordinary methods. Data were analyzed by SPSS-11, using ANOVA and post hoc Tukey tests. Results were expressed as mean±SD, and statistical difference was considered significant by p<0.055T.
Results: Results in the present study showed that fasting blood glucose (FBS), total cholesterol (TCho), triglyceride (TG), LDL, food and water intake were significantly decreased in group C compared with those of group B, but body weight gain was significantly increased compared with that of control group (B)5T.
Conclusion: These results indicated that Urtica dioica decoction caused decreased FBS and improved serum lipids in diabetic male rats. Some more studies have shown the same mechanism5T.

Keywords

Urtica dioica Lipid profiles Rat Glucose Diabetes

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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