Inhibition Effects of Teucrium Polium Extract on Gout

AUTHORS

Elnaz Saghafi 1 , Manijeh Mianabadi 1 , * , Gholamreza Hadadchi 1

AUTHORS INFORMATION

1 Department of Biology, Faculty of Science, Golestan University, Gorgan, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (11); e92791
Published Online: November 24, 2012
Article Type: Research Article
Received: May 19, 2012
Revised: July 07, 2012
Accepted: August 18, 2012

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Abstract

Background: Teucrium polium (lamiaceae) is a natural source containing numerous
antioxidant compounds and T. polium had advised for treatment of wide range of diseases
including gout, inflammation and diabetes. In this Study, inhibitory effect of extracts, the
most important antioxidant contents of T. polium and correlation between them had
determined.
Materials and Methods: Flowering branches of T. polium were collected from nine regions in north-eastern provinces of Iran and dried and powdered afterwards. The inhibitory effects of the plant extract on xanthine oxidase were assayed in vitro. Total Phenol and anthocyanin and soluble sugar content of each extract were matured. Then, their correlations with the inhibitory effects on xanthine oxidase were also determined. All these measurements were repeated three times and variance analysis was used for comparing means.
Results: All extract in different habitat exhibited a good inhibition effects on xanthine oxidase activity, the concentration of 0.3 mg/ml of samples were inhibited the enzyme from 11.44 to 91.45%. The highest inhibitory effect on xanthine oxidase was found in Ramian by 91.45%. Anthocyanin content in Golestan’s samples (Tilabad) was remarkably more than other samples, 4.26 mg/g DW. Razari khorasan’s samples (Garmab) had the highest of total phenol and soluble sugar contents, 28.11 and 6.84 mg/g DW respectively.
Conclusion: These results suggest that T. polium extract in different regions is a rich source of antioxidant and has inhibitors effect on xanthine oxidase. Golestan samples had the highest inhibitory effect on the xanthine oxidase activity and are recommended for pharmacological studies.

Keywords

Teucrium polium Xanthine Oxidase Inhibition Antioxidant Gout

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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