Effects of Supplementation of Turmeric Extract on Balance Antioxidant- Prooxidant Spleen and Heart Tissues in Rats Exposed to Lead


sadeq saberi 1 , * , parvin farzanegi 2 , Shima Ranjbar 1 , Ahmad Gholizade 3 , Jalil Jafari 4 , Hadis Saberi 5 , Amin Talebolhagh-Kakhki 2


1 MSc of Exercise Physiology, Education of Golestan, Golestan, Iran

2 Department of Exercise Physiology, Faculty of Human Sciences, Azad University of Sari, Sari, Iran

3 Department of Physical Education, Birjand University, Birjand, Iran

4 Department of Exercise Physiology, Faculty of Physical Education, Shahid Rajaee University, Tehran, Iran

5 MA of Mathematical, Teacher Training University of Sabzevar, Sabzevar, Iran


Zahedan Journal of Research in Medical Sciences: 15 (11); e92802
Published Online: January 30, 2013
Article Type: Research Article
Received: May 27, 2012
Revised: June 20, 2012
Accepted: July 19, 2012




Background : One of today's environmental crisis that industrial technology it produces. Lead is one of the most important environmental contaminants that prolonged contact with the production of free radicals. Study results show that air pollution is increases mortality due to cardiovascular disease.
Materials and Methods :
To study the effects of consumption turmeric extracts on prooxidant- antioxidant balance of rats' spleen and heart tissues exposed to lead acetate. Thirty-six male rats randomly were classified into four groups as: 1) Basic, 2) Sham (turmeric solvent), 3) Lead, 4) turmeric extract+lead, (each group includes 9 rats). turmeric supplements were injected three times per week and total of 8 weeks to 30 mg/kg body weight. Injection protocol lead and turmeric extract or solvent (ethyl first) three sessions a week and will run for 8 weeks, all injections were in peritoneally.
Results : After separation of spleen and heart tissues and homogenization, showed injection of lead increases the index of lipid peroxidation in spleen and heart tissues. Also turmeric supplementation inhibits oxidative effects on the spleen and heart.
Conclusion : Based on this research findings using a healthy style, and herbal supplements is effective in reducing the harmful effects anti-oxidation pollutants.


Pollutants Prooxidant Antioxidant Rat Turmeric extract Spleen Heart

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