Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice

AUTHORS

shahrzad khakpour 1 , * , Meisam Akhlaghdoust 2 , Sara Naimi 2 , S. Mohammad-Javad Mirlohi 2 , Media Abedian 2 , Nazilla Sadat Seyed-Forootan 2 , Fatemeh Foroughi 2

AUTHORS INFORMATION

1 Department of Physiology, Medical Sciences Research Center, Islamic Azad University, Tehran Medical Branch, Tehran, Iran

2 Medical Students Research Committee, Islamic Azad University, Tehran Medical Branch, Tehran, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (11); e92804
Published Online: February 02, 2013
Article Type: Research Article
Received: October 09, 2012
Revised: November 20, 2012
Accepted: January 23, 2013

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background : Hypercholesterolemia and atherosclerosis are the most common causes of mortality and disability, especially in developed countries. The aim of this research was to evaluate the effect of Biebersteina multifida DC. root extract on HDL and LDL blood level.
Materials and Methods : In this experimental study, 35 male Balb/c mice were randomly divided in five groups such control, sham, and experimental groups which received Biebersteina multifida DC. root extract with the doses of 4, 5 and 10 mg/kg three last groups were daily fed orally, for thirty days. HDL and LDL blood serum levels were measured, in the last day and compared with control and sham groups.
Results : The results after 30 days gavage of 4, 5 and 10 mg/kg of Biebersteinia Multifida DC. root extract showed that the root extract decrease of LDL level significantly. The doses of 4, 5 mg/kg of the root extract were the effective dose in decreasing the serum HDL level. However, 10 mg/kg dose of root extract has no significant effect on HDL level in comparison with control and sham groups. 10 mg/kg of root extract had the maximum effect on reducing LDL level.
Conclusion : According to this study, it is suggested that the root extract of Biebersteinia multifida DC. can be efficient to reduce the level of HDL and LDL in blood serum.

Keywords

Bibersteinia multifida DC. HDL LDL Mice

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Fulltext

The full text of this article is available on the PDF file.

References
  • 1. The References of this article are available on the PDF file.
  • COMMENTS

    LEAVE A COMMENT HERE: