Effect of Pistacia Atlantica Extract on Glutathione Peroxidase Tissue Levels and Total Oxidative Capacity of Liver and Plasma Lipid Profile of Rats

AUTHORS

Parvin Farzanegi 1 , * , Monireh Mousavi 1 , Abbass Ghanbari-Niaki 2

AUTHORS INFORMATION

1 Department of Exercise Physiology, Faculty of Humanities, Islamic Azad University Sari Branch, Sari, Iran

2 Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran

How to Cite: Farzanegi P , Mousavi M, Ghanbari-Niaki A . Effect of Pistacia Atlantica Extract on Glutathione Peroxidase Tissue Levels and Total Oxidative Capacity of Liver and Plasma Lipid Profile of Rats, Zahedan J Res Med Sci. 2013 ; 15(11):e92809.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (11); e92809
Published Online: February 10, 2013
Article Type: Research Article
Received: January 25, 2012
Revised: March 17, 2012
Accepted: May 20, 2012

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Abstract

Background : Exercise causes increased oxygen consumption, leaving cells exposed to oxidative stress. Antioxidants may have a protective effect by inhibiting lipid peroxidation. Thus, this study aims to examine the effect of Pistacia atlantica extract on glutathione peroxidase levels and total oxidative capacity of liver and plasma lipid profile of rats.
Materials and Methods : In this experimental study, 28 female rats’ weight 155.8±2.7 grams were randomly and equally divided into 4 groups of exercise-saline, control-saline, exercise-mastic, and control-mastic. The exercise groups exercised for 8 weeks (5 days per week, 60 minutes daily, 25 meters per minute, on a zero degree slope). The rats received equal volumes of mastic and saline orally for 4 weeks. Blood and tissue samples were taken 72 hours after the last exercise session. Data were analyzed using one-way variance analysis (ANOVA).
Results : Consumption of Pistacia atlantica extract together with endurance exercising for 8 weeks did not significantly affect glutathione peroxidase concentration, total oxidative capacity, LDL, triglyceride, or cholesterol, but significantly reduced HDL (p=0.002).
Conclusion : Results showed that antioxidant and lipid profile levels were not affected by consumption of supplements and endurance exercising. However, further studies are required to assess the long term effects of this herbal extract.

Keywords

Glutathione peroxidase Total oxidative capacity Lipid profile Pistacia atlantica Endurance exercise

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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