Oxalate-Degrading Capacities of Gastrointestinal Lactic Acid Bacteria and Urinary Tract Stone Formation

AUTHORS

Mohammad Kargar 1 , * , Rouhi Afkari 2 , Sadegh Ghorbani-Dalini 2

1 Department of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran

2 Department of Microbiology, Young Researcher’s Club, Jahrom Branch, Islamic Azad University, Jahrom, Iran

How to Cite: Kargar M , Afkari R, Ghorbani-Dalini S. Oxalate-Degrading Capacities of Gastrointestinal Lactic Acid Bacteria and Urinary Tract Stone Formation, Zahedan J Res Med Sci. 2013 ; 15(10):e92834.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (10); e92834
Published Online: May 22, 2013
Article Type: Research Article
Received: February 18, 2012
Revised: March 05, 2012
Accepted: May 12, 2012

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Abstract

Background: Calcium oxalate is one the most significant causes of human kidney stones. Increasing oxalate uptake results in increased urinary oxalate. Elevated urinary oxalate is one the most important causes of kidney stone formation. This study aims to evaluate oxalate-degrading capacity of lactic acid bacteria and its impact on incidence of kidney stone.
Materials and Methods: This case-control study was conducted on serum, urinary, and fecal samples. The research population included a total of 200 subjects divided in two equal groups. They were selected from the patients with urinary tract stones, visiting urologist, and also normal people. The level of calcium, oxalate, and citrate in the urinary samples, parathyroid and calcium in the serum samples, and degrading activity of fecal lactobacillus strains of all the subjects were evaluated. Then, data analysis was carried out using SPSS-11.5, X2 test, Fisher’s exact test, and analysis of variance. 
Results: The results revealed that the patients had higher urinary level of oxalate and calcium, as well as higher serum level of parathyroid hormone than normal people. In contrast, urinary level of citrate was higher in normal people. In addition, there was a significant difference between the oxalate-degrading capacities of lactobacillus isolated from the patients and their normal peers.
Conclusion: Reduction of digestive lactobacillus-related oxalate-degrading capacity and increased serum level of parathyroid hormone can cause elevated urinary level of oxalate and calcium in people with kidney stone.

Keywords

Oxalate degradation Digestive lactobacillus Kidney stones

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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