Effect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats

AUTHORS

Negar Keyshams 1 , S. Reza Fatemi 2 , Hossein Najafzadeh 3 , * , Ali Ashrafi 4

AUTHORS INFORMATION

1 Department of Physiology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran

2 Department of Physiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

4 Department of Materials, Faculty of Engineering, Shahid Chamran University, Ahvaz, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (10); e92836
Published Online: March 12, 2013
Article Type: Research Article
Received: June 14, 2012
Revised: May 01, 2012
Accepted: July 11, 2012

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Abstract

Background : Vanadium compounds have antidiabetic, but there is no study about the antidiabetic effects f ammonium monovanadate nono-particles. In this study, antidiabetic effect of ammonium monovanadate was compared with its nonoparticles.
Materials and Methods : In this experimental and animal modeling study, 42 male Sprague Dawley rats were divided in 6 groups (each group 7 rats). Diabetes was induced by IP injection of 60 mg/kg streptozicin to five groups. One normal group and one diabetic group were kept without treatment as control groups. Other diabetic rats were treated with nonovanadate 25 mg/kg (NV25), ordinary vanadate 25 mg/kg (V25), nonovanadate 15 mg/kg (NV15) and water ordinary vanadate 25 mg/kg (WV25) groups for 10 days by gavage. Heparinized blood was collected at days 11 and 21 and centrifuged to separate plasma. Glycosylated hemoglobin, insulin, triglyceride (TG), total cholesterol (TC), HDL-c and LDL-c were measured at both time and compared between groups.
Results : All treatment except in V25 decreased glycemia, but insulin increased only in NV25 group (p<0.05). All treatment decreased TG, TC and LDL-c significantly (p<0.001).
Conclusion : Ammonium mono vanadate nonoparticle has better effects than ordinary ammonium mono vanadate on some biochemical factors in experimental diabetes.

Keywords

Ammonium mono vanadate nanoparticle Diabetes Rat

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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