Comparative Study of Intrathecal Dexamethasone with Epinephrine as Adjuvants to Lidocaine in Cesarean Section

AUTHORS

Fereshteh Naziri 1 , S. Mozafar Rabiee 1 , Nadeia Banihashem 1 , * , Keyvan Hosseinjanzadeh 1 , Zeiba Shirkhani 2 , S. Sedigheh Solimanian 2

1 Department of Anaesthesiology and Intensive Care, Babol University of Medical Sciences, Babol, Iran

2 Researcher, Babol University of Medical Sciences, Babol, Iran

How to Cite: Naziri F, Rabiee S M, Banihashem N , Hosseinjanzadeh K, Shirkhani Z, et al. Comparative Study of Intrathecal Dexamethasone with Epinephrine as Adjuvants to Lidocaine in Cesarean Section, Zahedan J Res Med Sci. 2013 ; 15(9):e92848.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (9); e92848
Published Online: January 07, 2013
Article Type: Research Article
Received: July 08, 2012
Revised: August 17, 2012
Accepted: September 20, 2012

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Abstract

Background : Different additives have been used with local anesthetics to provide prolonged duration of sensory block in spinal anesthesia. The aim of present study was to evaluate the onset and duration of sensory block of intrathecal dexamethasone and epinephrine as adjuvants to lidocaine in patients who were candidate for cesarean section.
Materials and Methods : This double-blind clinical trial research was conducted on 90 pregnant women candidate for cesarean section under spinal anesthesia. Patients were randomly allocated to receive intrathecally either 75 mg hyperbaric lidocaine plus 100 μg epinephrine or 75 mg hyperbaric lidocaine plus 4 mg dexamethasone or 75 mg hyperbaric lidocaine. The onset and duration of sensory block as well as postoperative analgesia were assessed.
Results : The time to reach the peak sensory block in lidocaine group was shorter than that of other two groups (p<0.001). Duration of sensory block in the control group, dexamethasone group, and epinephrine group were 64.16±7.99 min, 74.79±12.78 min, and 99.30±10.93 min, respectively (p<0.001).
Conclusion : The present research shows that intrathecal dexamethasone and intrathecal epinephrine as adjuvant to lidocaine increases sensory block duration in the women candidate for cesarean section.

Keywords

Lidocaine Dexamethasone Epinephrine Spinal anesthesia Cesarean section

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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