Serum Level of Trace Elements (Zinc, Lead, and Copper), Albumin and Immunoglobulins in Asthmatic Children

AUTHORS

Javad Ghaffari 1 , * , Houshang Rafatpanah 2 , Zeinab Nazari 3 , Ali Abaskhanian 1

AUTHORS INFORMATION

1 Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran

2 Inflammation and Inflammatory Diseases Research center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (9); e92851
Published Online: May 20, 2013
Article Type: Research Article
Received: February 09, 2013
Revised: March 01, 2013
Accepted: April 18, 2013

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Abstract

Background : Bronchial asthma (BA) is a chronic inflammatory disease and it is a major health problem. Trace elements such as copper and zinc are essential components of anti-oxidant enzymes and optimal function of the immune response. Changes in the levels of these elements may lead to increase the risk of asthma.
Materials and Methods : The study group consisted of 175 asthmatic children and 165 control group of healthy general population who attend the outpatient allergic clinic (Bou Ali Hospital) in Sari, Mazandaran, Iran between August 2010 and March 2011. Complete blood count, eosinophil count and serum total IgE level and Serum trace element levels (Zinc, lead and copper) were measured in both groups.
Results : There was a significant difference in serum levels of copper, lead, IgE (increased), and decreased IgA, between two groups (p=0.001). There was no significant difference in blood zinc levels and eosinophilia between two groups (p=0.732 and 0.068, respectively).
Conclusion : Increased serum levels of copper and lead may be associated with asthma.

Keywords

Children Asthma Zinc Lead Copper

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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