Comparison Between the Effects of the Alcholic Extract of Mellissia Officinalis and Atorvastatin on Serum Levels of Thyroid Hormones in Hypercholesterolemic Male Rats

AUTHORS

Ali Zarei 1 , Saeed Changizi Ashtiyani 2 , * , Mansour Sokhandani 3 , Azam Rezaei 4 , Saeed Zaheiri 5 , Soheila Taheri 6

AUTHORS INFORMATION

1 Department of Physiology, Science and Research Branch, Azad University of Damghan, Damghan, Iran

2 Department of Physiology, Arak University of Medical Sciences, Arak, Iran

3 Department of Nursing, Shiraz University of Medical Sciences, Shiraz, Iran

4 Department of Physiology, Azad University of Arsanjan, Arsanjan, Iran

5 Department of Biology, Payam-e-Noor University, Tehran, Iran

6 Staff of Education Development Center, Arak University of Medical Sciences, Arak, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (8); e92894
Published Online: December 30, 2012
Article Type: Research Article
Received: May 09, 2012
Revised: July 20, 2012
Accepted: October 14, 2012

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Abstract

Background: Consumption of unsaturated fats reduces the serum level of lipids and leptin.
Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are interrelated.
This study was done to compare the effects of Mellissia officinalis extract and
atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.
Materials and Methods: Consumption of unsaturated fats reduces the serum level of lipids
and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their
amounts are inter-related. This study was done to compare the effects of Mellissia
officinalis extract and atorvastatin on the serum levels of thyroid hormones in
hypercholesterolemia rats.
Results: The results showed that in experimental groups receiving the plant extract and
atorvastatin, the concentration of thyroid hormones increased, whereas the amount of the
thyroid-stimulating hormone showed a significant decrease (p<0.05).
Conclusion: Mellissia officinalis extract decreases TSH but it increases T3 and T4. Further
studies are required for applying this extract to the treatment of hyperthyroidism.

Keywords

Atorvastatin Hypercholesterolemia Mellissia officinalis Thyroid

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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