The Effects of Hydro-Alcoholic Extract of Zingiber Officinale on Prevention from Plumbism in Kidney Tissue of Neonatal Rats


Habibollah Johari 1 , * , Fatemeh Delirnasab 2 , Esfandiar Sharifi 2 , Vahid Hemayat-Khah 3 , Mohammadali Pourdanesh 4 , Hosein Kargar 3 , Maryam Nikpour 5 , Mohammad Yazdani 6


1 Department of Physiology, Darab Branch, Islamic Azad University, Darab, Iran

2 Department of Physiology, Kazeron Branch, Islamic Azad University, Kazeron, Iran

3 Department of Physiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran

4 Department of Histology, Jahrom Branch, Islamic Azad University, Jahrom, Iran

5 Student Research Committe, International Branch, Shiraz University of Medical Science, Shiraz, Iran

6 Department of Agriculture, Firouz-Abad Branch, Islamic Azad University, Firouz Abad, Iran


Zahedan Journal of Research in Medical Sciences: 15 (8); e92896
Published Online: December 30, 2012
Article Type: Research Article
Received: October 17, 2011
Revised: October 29, 2011
Accepted: November 16, 2011




Background: In the present research, the effects of hydro-alcoholic extract of Zingiber
officinale (ginger) on treating lead-poisoned kidney of neonatal rats was studied.
Materials and Methods: This research was conducted as a laboratory work. The neonatal
rats were divided into 7 groups of 10 samples. The first control group received no
treatment. The second control group received 0.1 mg of distilled water. As an
experimental group, the one received an amount of 0.6 g/l lead. The fourth group received
only 2 g/kg body weight of hydro-alcoholic extract of ginger. Groups 5 to 7 each initially
received 0.6 g/l lead and then amounts of 0.5, 1 and 2 g/kg hydro-alcoholic extract of
ginger. The injections were administered via oral gavage during 10 consecutive days.
Results: According to the obtained results, the body and kidney weights showed a
significant reduction in experimental groups that had received amounts of 1 and 2 g/kg in
comparison with the group that had received lead. The kidney weight of the group that had
received only extract showed no significant difference in comparison with the control
group. As for the body weights, however, it showed a significant increase. Moreover, the
body and kidney weights of the lead-injected group showed a significant increase in
comparison with the control group.
Conclusion: Lead can cause damage to kidney tissues. Due to its antioxidant and
protective effect, ginger can be a medication to nephrotoxicity of lead and prevent kidney
tissues from destruction.


Zingiber officinale (ginger) Lead Kidney Rats Poisoning

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