In Vitro Antibacterial Properties of Aqueous Garlic Extract (AEG) Against Multidrug-Resistant Enterococci

AUTHORS

Mohammad Bokaeian 1 , * , Zakaria Bameri 2

AUTHORS INFORMATION

1 Department of Laboratory Sciences, Faculty of Paramedical Sciences, Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

2 Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

How to Cite: Bokaeian M , Bameri Z. In Vitro Antibacterial Properties of Aqueous Garlic Extract (AEG) Against Multidrug-Resistant Enterococci, Zahedan J Res Med Sci. 2013 ; 15(6):e92961.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (6); e92961
Published Online: October 29, 2012
Article Type: Research Article
Received: January 31, 2012
Accepted: April 19, 2012

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Abstract

Background : As relatively avirulent enteric bacteria, enterococci usually cause infections in immune-compromised patients. The antimicrobial treatment, however, is quite challenging, since enterococci are intrinsically resistant to many antibiotics. Objective of the present study was to examine the antibacterial activity of aqueous garlic extract on isolates of enterococci.
Materials and Methods : In this descriptive research, a total of 120 enterococcus isolates including 70 multidrug-resistant isolates causing different infections were collected from three hospitals in Zahedan. The susceptibility of isolates to different antibiotics was measured by agar diffusion test and antibacterial activity of garlic extract was measured using disc-diffusion and microbroth dilution methods.
Results : Among 120 enterococcus samples, 95 (79.2%) and 25 (20.8%) isolates were E. faecalis and E. faecium respectively. The highest resistance was observed in erythromycin (95.8%) and the lowest resistance (6.7%) in chloramphenicol, while 88.3% and 65.8% of the isolates were resistant to tetracycline and ampicillin respectively. Moreover, 58% of the isolates were Multi-Drug Resistant (MDR) and showed resistance to at least three antibiotics. Antibacterial activity of AGE was characterized by inhibition zones of 16.8±1.8 mm and Minimum Inhibitory Concentration (MIC) ranged from 4 to 32 mg/ml.
Conclusion : The present study suggests that AGE has a significant anti-enterococcal effect and therefore, supports the use of garlic as an herbal remedy in Zahedan.

Keywords

Garlic MIC MDR Enterococcus

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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