Effect of Hexanic and Alcoholic Extracts of Fenugreek Seed in Male Diabetic Rats

AUTHORS

Mahmood Abedinzade 1 , * , Iraj Nikokar 1 , Sima Nasri 2 , Masome Jamal Omidi 2 , Farzad Nursabaghi 2

AUTHORS INFORMATION

1 Department of Physiology, Zeinab Para Medicine-Nursing & Midwifery School, Guilan University of Medical Science, Langrood, Iran

2 Department of Biology, Payam-e-Noor University, Tehran, Iran

How to Cite: Abedinzade M , Nikokar I, Nasri S, Jamal Omidi M, Nursabaghi F. Effect of Hexanic and Alcoholic Extracts of Fenugreek Seed in Male Diabetic Rats, Zahedan J Res Med Sci. 2013 ; 15(6):e92962.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (6); e92962
Published Online: October 29, 2012
Article Type: Research Article
Received: March 12, 2012
Accepted: May 16, 2012

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background : Diabetes mellitus is recognized with severe complications. Many herbal medicines have been recommended for treatment of diabetes problem. In this study, the effect of hexanic and alcoholic extracts of fenugreek (Trigonella-foenum graecum) on serum parameters was investigated in normal and streptozotocin-induced diabetic rats.
Materials and Methods : This experimental study was carried out in 2011 at paramedical school of Guilan University of Medical Sciences, 48 male Sprague Dawley rats (230-300 gram) were divided into six groups: control, type 1 diabetic, and 2 diabetic groups that receive alcoholic extract and 2 groups receive hexanic extract of fenugreek (100, 200 mg/kg body weight) intraperitonealy for 28 days. For diabetes induction, streptozotocin (60 mg/kg/ intraperitonealy) was used. Blood glucose, total cholesterol, triglyceride (TG), urea, creatinine, uric acid, AST and ALT level was measured. Data were analyzed with spss software 16 and One Way ANOVAs and Tukey test. p<0.05 was statistically significant.
Results : fenugreek extract inhibit weight loss especially in diabetic groups that receive hexanic extract (p=0.006). blood glucose, total cholesterol, TG, urea, creatinin, uric acid, AST and ALT level was reduced significantly in diabetics groups that receive fenugreek extract (p=0.001). This effect was stronger in groups that receive Hexanic extract
Conclusion : Fenugreek is a good candidate for reduction of diabetic complications. 

Keywords

Diabetes Complications Trigonella Cholesterol Blood glucose

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

The full text of this article is available on the PDF file.

 

References

  • 1. The References of this article are available on the PDF file.
  • COMMENTS

    LEAVE A COMMENT HERE: