Effect of Hydro-Alcoholic Extract of Teucrium Polium on Castor Oil-Induced Diarrhea in Male Rat

AUTHORS

Mohammad Allahtavakoli 1 , * , Rezwan Moradi 2 , Sakineh Shamsi 2 , Kianoosh Afsharmanesh 2

AUTHORS INFORMATION

1 Department of physiology, Physiology-Pharmacology Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

2 Medical Student, Physiology-Pharmacology Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (6); e92964
Published Online: October 29, 2012
Article Type: Research Article
Received: August 23, 2011
Accepted: April 26, 2012

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Abstract

Background : Diarrhea is one of the world's health problems as the most common causes of death in children. In this study, the effect of Teucrium Polium (TP) extract on diarrhea induced by castor oil has been studied.
Materials and Methods : 30 male rats were divided into five equal groups containing extract with doses of 100, 200 and 600 mg/kg diphenoxylate (5 mg/kg) and control group or vehicle (normal saline) groups. One hour after feeding the drugs or vehicle in the volume of 10 ml/kg, 2 ml of castor oil were fed to each animal through an oral-gastric catheter. Then excrements of animals were separately observed in the cages for 4 hours and their quality, frequency and stool weight were determined. Data analysis was performed using one-way ANOVA and Tukey post-test and p<0.05 was considered as significant.
Results : Diphenoxylate and 600 mg/kg dose of TP reduced the percentage of the weight loss of animals, their excretion frequency and defecation index (p< 0.001). The 600 mg/kg dose of TP decreased the fecal water content compared to the control group (p< 0.01).
Conclusion : Based on our data, essential oil of TP has an effect similar to diphenoxylate on the reduction of osmotic diarrhea symptoms and also reduces the volume of excreted water.

Keywords

Diarrhea Teucrium Polium Rat

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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