Exposure to Noise Pollution and Its Effect on Oxidant and Antioxidant Parameters in Blood and Liver Tissue of Rat
Zahedan Journal of Research in Medical Sciences: May 31, 2013, 15 (5); e92972
November 18, 2012
Article Type: Research Article
March 22, 2012
May 22, 2012
S. Exposure to Noise Pollution and Its Effect on Oxidant and Antioxidant Parameters in Blood and Liver Tissue of Rat,
Zahedan J Res Med Sci.
Noise is a known physical stress in workplace, which induces alterations of various physiological responses in exposed individuals. Aim of this study was to explore the status of oxidant and antioxidant parameters in blood and liver tissue of rats exposed to noise. Background : Twenty-one adult albino wistar male rats seven in each of the following groups were used (N=7): 1- Control group, 2- Noise exposure (100 dB, 700-5700 Hz, 8 h/day, 8 days), 3- Noise exposure (100 dB,700-5700 Hz, 8 h/day, 14 days). The animals were anesthetized by CO2 and after decapitation, blood and liver samples were collected and processed for estimation of biochemical parameters (MDA and GSH levels) in control and exposed groups. Materials and Methods : The present research findings showed significant decrease in liver weight and liver/body weight ratio in noise exposed groups compared to the control group ( Results : p<0.05). Fourteen days noise exposure caused a statistically significant increase in MDA level in serum and liver tissue and also statistically significant decrease in GSH level in serum ( p<0.05), however, the level of GSH in the liver tissue showed no significant change. 8-days exposure just caused a statistically significant increase in MDA level in serum, and there was no significant change in the other parameters. Moreover, the levels of changes in biochemical parameters in noise exposed groups were exposure time-dependent. The results of present study showed that exposure to noise is toxic to blood and liver tissue. Further research for exploring the toxicity of noise in occupationally exposed groups is recommended.
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