Effect of Erythromycin on Albendazole-Induced Teratogenicity in Pregnant Rats

AUTHORS

Reza Ranjbar 1 , Hossein Najafzadeh 2 , * , Hassan Morovvati 3 , Mahmood Khaksary Mahabady 1 , elnaz lak 4

AUTHORS INFORMATION

1 Department of Anatomy, Faculty of Veterinary Medicine, Shahid Chamram University, Ahwaz, Iran

2 Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamram University, Ahwaz, Iran

3 Department of Histology, Faculty of Veterinary Medicine, Shahid Chamram University, Ahwaz, Iran

4 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamram University, Ahwaz,Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (5); e92986
Published Online: November 18, 2012
Article Type: Research Article
Received: June 01, 2012
Accepted: October 24, 2012

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Albendazole is utilized as an anthelmentic agent. One its side effect is teratogenicity. This effect apparently is related to its metabolites especially albendazole sulfoxid. The aim of present study was evaluation effect of erythromycin (as enzyme inhibitor in biotransformation) on albendazole biotransformation and consequently fetal malformation.
Materials and Methods: Four groups of female pregnant wistar rats (8 rats each group) were used. First group received normal saline (as control group). A single oral dose 30 mg/kg of albendazole was administered to rats on day 10 of gestation in group 2. Rats in group 3 received albendazole similar group 2 and erythromycin at dose 60 mg/kg. Rats in group 4 received only erythromycin on day 10 of gestation. The rats were euthanatized on day 20 of gestation. The skeletal malformation of fetus was studied by stereomicroscope after staining by Alizarin red-Alcian blue
Results: The length and weight of fetuses were significantly decreased by albendazole but erythromycin did not prevent this effect. In group that received only erythromycin, the length and weight of fetuses was similar to control group. Erythromycin decreased albendazole effect on weight of placenta. There was an increase in resorption by erythromycin when co-administrated with albendazole. The incidence of skeletal malformations (mostly of the limbs, vertebrae and palate) decreased significantly by erythromycin when co-administrated with albendazole.
.
Conclusion: Thus, erythromycin may inhibit albendazole biotransformation and decrease teratogenicity of it metabolites; but this subject needs more detailed evaluation.

Keywords

Albendazole Erythromycin Teratogenicity Rats

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Fulltext

The full text of this article is available on the PDF file.

References
  • 1. The References of this article are available on the PDF file.
  • COMMENTS

    LEAVE A COMMENT HERE: